<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31554

Description Mediator of RNA polymerase II transcription subunit 21
SequenceMTDRLTQLQRCLDQVMEQFCATLNFIDKRHDFEPFNDKEPKMTDKHASVATPEEFSNGIDELSTDIIVKIRQITTLIDSLPGVGVSAEEQLHKIDSLQKKLVDIEDEKIHAIKKKDDLLKQVDDLITVFVGGIADSRRGTSLAPENVQEDNDIKQEAEVPTSSEAIEQKIANEKIESKIEGEYNDNINEDSDSKSADSELFMDKDDADNISESISPGKI
Length219
PositionMiddle
OrganismCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Nakaseomyces> Nakaseomyces/Candida clade.
Aromaticity0.04
Grand average of hydropathy-0.676
Instability index52.25
Isoelectric point4.42
Molecular weight24564.98
Publications
PubMed=15229592

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31554
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.67|      14|      15|      77|      90|       1
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   77-   90 (23.81/14.64)	IDSLPGVGVSAEEQ
   94-  107 (22.85/13.81)	IDSLQKKLVDIEDE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.21|      22|      38|     133|     154|       2
---------------------------------------------------------------------------
  133-  154 (37.29/20.93)	IADSRRGTSLAPE...NVQEDNDIK
  170-  194 (30.92/16.33)	IANEKIESKIEGEyndNINEDSDSK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31554 with Med21 domain of Kingdom Fungi
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