<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31545
Description |
Mediator of RNA polymerase II transcription subunit 21 |
Sequence | MTDRLTQLQQCLDQIVEQFGSAITYVDRNHDFEPHNELEDKLSDPQATIAAAEDFDRNIDELTTDMILKTRQIIKLIDSLPGVDVSAEEQLSRIDSLQKKLIQVEGEKIEAIKRKESLTKDIEELINEFTEGIANSRRLNKA |
Length | 142 |
Position | Middle |
Organism | Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes>
Saccharomycetales> Saccharomycetaceae> Eremothecium.
|
Aromaticity | 0.04 |
Grand average of hydropathy | -0.589 |
Instability index | 50.12 |
Isoelectric point | 4.58 |
Molecular weight | 16240.05 |
Publications | PubMed=15001715
PubMed=23749448
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors (By similarity).
ECO:0000250
|
GO - Cellular Component | mediator complex GO:0016592 IBA:GO_Central
|
GO - Biological Function | transcription coregulator activity GO:0003712 IBA:GO_Central
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IBA:GO_Central
|
Interaction
Repeat regions
Repeats |
>MDP31545
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 85.53| 30| 35| 45| 79| 1
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45- 75 (45.96/35.05) PQATIAAAEDFDRnIDELTTDMI.LKTRQI..IK
81- 113 (39.57/17.82) PGVDVSAEEQLSR.IDSLQKKLIqVEGEKIeaIK
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