<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31544

Description Mediator of RNA polymerase II transcription subunit 21
SequenceMDIISQLQEQVNTIAAITFNAFGTLQRDAPPVQLSPNYPEPPATTTVTDDATPFPEQPKQLSAGLVKAAKQFDALVAALPLSEGGEGAQLKRIAELQVENDLVGQELQKQLEAAEKELKQVQELFGQAADNCLNMKKPE
Length139
PositionMiddle
OrganismArabidopsis thaliana (Mouse-ear cress)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Brassicales> Brassicaceae> Camelineae> Arabidopsis.
Aromaticity0.04
Grand average of hydropathy-0.374
Instability index55.31
Isoelectric point4.46
Molecular weight15040.82
Publications
PubMed=19286969
PubMed=10617198
PubMed=27862469
PubMed=14593172
PubMed=17560376
PubMed=22021418

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for embryo development and defense against necrotrophic fungal pathogens. 
GO - Cellular Component
mediator complex	GO:0016592	IDA:UniProtKB
polar nucleus	GO:0043078	IMP:UniProtKB

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
C:polar nucleus	GO:0043078	IMUniProtKB
defense response to fungus	GO:0050832	IMUniProtKB
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central
regulation of transcription, DNA-templated	GO:0006355	TAS:TAIR









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31544
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.19|      19|      25|      81|     105|       2
---------------------------------------------------------------------------
   81-  105 (25.86/24.18)	LSEGGEGAQ..LKRIAELqvendlVGQ
  107-  127 (27.33/13.56)	LQKQLEAAEkeLKQVQEL......FGQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31544 with Med21 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DAPPVQLSPNYPEPPATTTVTDDATPFPEQPKQ
28
60










Molecular Recognition Features






MoRF SequenceStartStop




1) EQPKQLSAGLVKAAKQFDALVAALPL
2) GAQLKRIAELQVENDLV
56
87
81
103