Description | Mediator of RNA polymerase II transcription subunit 21 |
Sequence | MADRLTQLQDTVNQQAEHFCNSIGILQQCSVPSKFPGFERTGSQTPQQNQQEDYAQLFSTLISRCAKDIDTLIESLPSEESSIELQVQALKRLEIENQESAEKLEEVVRKGELLLEKIQAALSDIAQSQLDMQYSSSPKKQ |
Length | 141 |
Position | Middle |
Organism | Aedes aegypti (Yellowfever mosquito) (Culex aegypti) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Culicinae> Aedini> Aedes> Stegomyia. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.611 |
Instability index | 66.16 |
Isoelectric point | 4.58 |
Molecular weight | 15887.58 |
Publications | PubMed=17510324 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors (By similarity).
ECO:0000250 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | |
GO - Biological Process |
Binary Interactions |
Repeats | >MDP31542 No repeats found No repeats found |
MoRF Sequence | Start | Stop |
1) FERTG 2) LDMQYSSSPK 3) QNQQEDYAQLFSTLISRCAKDIDTLIESLP 4) SIELQVQALKRLEIENQESAEKLEEVVRK | 38 130 48 82 | 42 139 77 110 |
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