<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31523
Description |
Mediator of RNA polymerase II transcription subunit 1 |
Sequence | MVEGDSYVETLDSMIELFKDYKPGSITLENITRLCQTLGLESFTEELSNELSRLSTASKIIVIDVDYNKKQDRIQDVKLVLASNFDNFDYFNQRDGEHEKSNILLNSLTKYPDLKAFHNNLKFLYLLDAYSHIESDSTSHNNGSSDKSLDSSNASFNNQGKLDLFKYFTELSHYIRQCFQDNCCDFKVRTNLNDKFGIYILTQGINGKEVPLAKIYLEENKSDSQYRFYEYIYSQETKSWINESAENFSNGISLVMEIVANAKESNYTDLIWFPEDFISPELIIDKVTCSSNSSSSPPIIDLFSNNNYNSRIQLMNDFTTKLINIKKFDISNDNLDLISEILKWVQWSRIVLQNVFKLVSTPSSNSNSSELEPDYQAPFSTSTKDKNSSTSNTEPIPRSNRHGSVVEASRRRRSSTNKSKRPSITEAMMLKEEGLQQFNLHEILSEPAIEEENGDSIKEHSTTMDGANDLGFTASVSNQENAGTDIVMEDHGVLQGTSQNYGTATADDADIEMKDVSSKPSKPESSVLQLIVSEDHIILDTISECNLYDDVKCWSKFIEKFQDIVS |
Length | 566 |
Position | Middle |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes>
Saccharomycetales> Saccharomycetaceae> Saccharomyces.
|
Aromaticity | 0.09 |
Grand average of hydropathy | -0.559 |
Instability index | 47.92 |
Isoelectric point | 4.69 |
Molecular weight | 64250.47 |
Publications | PubMed=9169875
PubMed=24374639
PubMed=9892641
PubMed=11555651
PubMed=14562095
PubMed=14562106
PubMed=15175151
PubMed=15477388
PubMed=16002404
PubMed=16076843
PubMed=16109375
PubMed=16263706
PubMed=17192271
PubMed=17330950
PubMed=18407956
PubMed=19779198
PubMed=12191485
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. The Mediator complex, having a compact
conformation in its free form, is recruited to promoters by direct
interactions with regulatory proteins and serves for the assembly of a
functional preinitiation complex with RNA polymerase II and the general
transcription factors. The Mediator complex unfolds to an extended
conformation and partially surrounds RNA polymerase II, specifically
interacting with the unphosphorylated form of the C-terminal domain
(CTD) of RNA polymerase II. The Mediator complex dissociates from the
RNA polymerase II holoenzyme and stays at the promoter when
transcriptional elongation begins.
ECO:0000269 PubMed:11555651
ECO:0000269 PubMed:16076843
ECO:0000269 PubMed:16109375
ECO:0000269 PubMed:16263706
|
GO - Cellular Component | core mediator complex GO:0070847 IDA:SGD
mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | negative regulation of transcription by RNA polymerase II GO:0000122 IMSGD
positive regulation of transcription by RNA polymerase II GO:0045944 IMSGD
|
Interaction
Repeat regions
Repeats |
>MDP31523
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 60.68| 18| 43| 453| 495| 1
---------------------------------------------------------------------------
453- 470 (31.10/33.96) N.GDSIKEHSTTMDGANDL
546- 564 (29.57/18.46) NlYDDVKCWSKFIEKFQDI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
4| 189.36| 42| 43| 249| 290| 2
---------------------------------------------------------------------------
210- 244 (30.60/13.56) ............VPLAKiylEENKSDSQYrFYEYIYSQE.TKSWINES
249- 290 (72.41/41.70) SNGIS..LVMEIVANAK...ESNYTDLIW.FPEDFISPELIIDKVTCS
291- 331 (53.58/29.03) SNSSSspPIIDLFSN......NNYNSRIQ.LMNDFTTKLINIKKFDIS
353- 378 (32.77/15.02) QNVFK..LVSTPSSN......SNSSEL...EP.DYQAP..........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 37.17| 11| 23| 165| 175| 4
---------------------------------------------------------------------------
165- 175 (21.93/16.86) FKYFTELSH....YI
186- 200 (15.24/ 9.22) FKVRTNLNDkfgiYI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 42.13| 12| 16| 135| 146| 5
---------------------------------------------------------------------------
135- 146 (21.26/10.62) SDSTSHNNGSSD
152- 163 (20.87/10.30) SNASFNNQGKLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 49.95| 14| 43| 486| 499| 6
---------------------------------------------------------------------------
486- 499 (25.82/22.97) IVMEDHGVLQGTSQ
531- 544 (24.13/20.92) IVSEDHIILDTISE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 55.62| 18| 23| 66| 83| 7
---------------------------------------------------------------------------
66- 83 (29.09/17.84) DY.NKKQDRIQDVKLVLAS
89- 107 (26.53/15.67) DYfNQRDGEHEKSNILLNS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 30.41| 10| 17| 398| 408| 9
---------------------------------------------------------------------------
398- 408 (12.85/10.47) RSNRhGSVVEA
418- 427 (17.56/ 8.71) KSKR.PSITEA
---------------------------------------------------------------------------
|