Description | Mediator of RNA polymerase II transcription subunit 1 |
Sequence | MSSLLERLHSKYSQNRPWPETIKLVRQIMEKRTGMMSGSHQHLVSCLETLQKALKVSSLSAMTDRLESIARQNGLTSHLSPNGTECYITTDMFYLEVLLDTEGQLCDVKVAHHRENPVSCPELVEQLREKNFEDFSQHLKGLVNLYKVPGDNKLETKMYLALQSLELDLTKMAAMYWQATNASVLEKILHGTVGYLTPRSGGQVMSLKYYVSPYDLFDDTTGASISLSEGHAVPRSLGMNVSVTIEATSAMYKLPIAPLIMGSHPIDNKGTPSFTSITNANSVDLPACFFLKFPQPIPVSRAFIQKIQHCTGIPLIDGSHTFLPHYELVTQFELAKEKEPGTLNHNMRFYASLPGQQHCYFVNKDAPLPDGRSLQGTLLSKIPFQHPGRVPIILSLIRHQVACNTLIGSCVKRTMLKEDCPGLLQFEVAPLSDSCFSISFQHPVNDSLVCVVMDVQDSSHVSCKLYKGLSDALICTDDFITKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMASGSTALSGITTPTSSYTSGQISSLFNMGIKERHDSAGHGDDFSKVTQNPILTSLLQITSNSGGTLGSSPTPPQHTPPPASSPASNTKNHPMLMNLLKDNPAQDFSTLYGGSPLERQNSSGSPRTELGSSASGKPKKKRPRTGTEKMKNQTEDDFQRELFSMDVDSQNTIFDVGMAGDALDTPHITPAPSQCGTPPNVYQQAIPHTQANMQRMVRIPSTDAIIPDVTDILSDIAEEASKLPGPGEDCPNLGTPVRDSSSSGHSQSTLFDTDVFQVDGGGGSGGENPYPDPVDLIVDSHGSPNSDSPNTFFNSVDFNPDLLNSQSQSGFTDDLNDDSSQSGDNDFKDFAGPGLASLGIVSGLPVDGGDGKYKMALGADTVDFSIIAGGGSKNLGGPDIQETQSRSQSPLLGSDLGKDRPQKQKVKESGNGGGAGGGLSGMQSAGMEGKSMKRSRTPSSDGKSKDKPPKRKKTESDGKSPSHITNRPFTPPTSTGGSKSPGTSGRSQTPPGMATPPIPKITIQIPKGTMSVGKPSSHSQYSSSGSSSSSSSKSHHGHSSLSSSASGKIKSNKSDGSSGMKIGSSGGGMYSGQSGQSNSQSKNSSQSMGKAGSSPITKHGLSSNVNNSSGSKTKPQGKPSVLMNPSLSKPNISPSHSRPSGGSDKLSSPMKPMPGTPPSSKAKSPIGSGGQHLSGSGSNSTTKSSSGLVSSGSLTQKPNSSSSSSSSSSSSSSSSSSSSSSFSSGVSQNLHSSSKGKSPSRNKKPSLTAVIDKLKHGVGTGGPGSEDPMDGGVGGGSTGAPSHGMSSKHGLGVGEFPTKREKGEKDKSKGSSGGPSDPSKKGGGDSKGSVSTGVAKIIISKHDGGSPSIKAKVTLQKPEGGGEGLRSQMQKNYGSPLISGSTPKHERCSPSHNKSPAYTPQALDSESESGSSSIAEKSYQNSPSSDDGGGSGSRAQTEYSAEKHKKHKKEKKRLKDKDRDREKKKSYTMKPESWSKSPISADPTMAMGGGAMMSSDRASRPTPSFLMGDDDDLIDVPLTL |
Length | 1573 |
Position | Middle |
Organism | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Amphibia> Batrachia> Anura> Pipoidea> Pipidae> Xenopodinae> Xenopus> Silurana. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.622 |
Instability index | 53.81 |
Isoelectric point | 8.85 |
Molecular weight | 165654.07 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors (By similarity).
ECO:0000250 UniProtKB:Q15648 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP31522 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 11| 913.86| 92| 97| 1114| 1205| 1 --------------------------------------------------------------------------- 531- 613 (80.44/15.88) ...S...P.................GY...GMASGS.............TALSGITTPT............................SSYTSGQ............I........SS...LF....NM........GIKER........HDS........AG....HG.DDFSKV.......T...QNP.ILtSL..LQIT.....SN........SGGTLG.SSP....TPpqhtP 614- 683 (61.10/10.45) PPAS...S.................PA...........................SNTKN............................HPMLMNLlkdnpaqdfstlY........GGS.PLE....RQ......................NS........SG.S........PRT.......E...LGS.SA.SG.....K....PKK..KR...PRTGTEKM.............. 684- 782 (72.54/13.66) KNQT...E.................DDfqrELFS..................MDVDSQN............................TIFDVGM............A........GDA.LDT....PHitpapsqcGTPPN.......VYQQ........AI.PHTQA.NMQRMV.......R...I.P.ST.DAiiPDVT....DIL..SD...IAEEASKLPGP....GE....D 791- 952 (60.50/10.28) RDSS...SsghsqstlfdtdvfqvdGG...GGSGGEnpypdpvdlivdsHGSPNSDSPNtffnsvdfnpdllnsqsqsgftddlnddSSQS.GD............N........DFK.DFA....GP........GLASLgivsglpVDGG........DG.KYKMA.LGADTVdfsiiagG...GSK.NL.GG..PDIQ....ETQ..SRsqsPLLGSD.LG.......K....D 958- 1021 (63.69/11.17) KVKE...S...............gnGG...GAGGGL.............SGM...QSAG...........................mEGKSM.K............R........SRT.P..............................SS........DGkSKDKP....PKR.......K...KTE.SD.GK.....S....PSHitNR........................P 1024- 1104 (100.22/21.44) PPTS...T.................GG...SKSPGT.............SGRSQTPP...................................GM............A.........TP.PIP....K..........ITIQ.......IPKG.............TMS.VGKPSS.......H...SQY.S..SS..GSSS....SSS..SK...SHHGHSSLSSSasgkIK....S 1114- 1205 (166.40/40.04) KIGS...S.................GG...GMYSGQ.............SGQSNSQSKN............................SSQSMGK............A........GSS.PIT....KH........GLSSN.......VNNS........SG.SKTKP.QGKPSV.......L...MNP.SL.SK..PNIS....PSH..SR...PSGGSDKLSSP....MK....P 1218- 1264 (72.73/13.72) PIG....S.................GG...QHLSG..............SG.SNSTTK.............................SS..................................................SG.......L.VS........SG.SLTQ...........................K..PNSS....SSS..S............SSS....SS....S 1267- 1361 (79.87/15.72) SSSS...S.................SS...SFSSGV.............SQNLHSSSKG............................KSPSRNK............K........PSL.TAVidklKH........GVGTG.......GPGSedpmdggvGG.GST....GAPSH.......G...MS.....SK..HGLGvgefPT...KR...EKGEKDK.S............. 1362- 1453 (83.28/16.68) .KGS...S.................GG...P..SDP.............SKKGGGDSKG............................SV.STGV............AkiiiskhdGGS.PSI....KA........KVTLQ.........................KP.EGGGEG.......LrsqMQK.NY.GS..PLIS.gstPKH..ER...CSPSHNK..SP...aYT....P 1455- 1548 (73.10/13.82) ALDSeseS.................GS...SSIAEK.............SYQNSPSSDD............................GGGSGSR............A........QTEySAE....KH........KKHKK.......EKKR........LK.DKDRDrEKKKSY.......T...MKPeSW.SK..SPIS....ADP..TM...AMGGGAMMSS............ --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 43.59| 11| 50| 308| 318| 2 --------------------------------------------------------------------------- 308- 318 (23.87/12.10) QHCTGI....PLIDG 357- 371 (19.73/ 8.76) QHCYFVnkdaPLPDG --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 110.02| 35| 50| 139| 175| 3 --------------------------------------------------------------------------- 139- 175 (50.89/43.61) LKGLVNlYKVP..GDNKLETKMYLALQSLeLDLTKMAAM 189- 225 (59.13/40.55) LHGTVG.YLTPrsGGQVMSLKYYVSPYDL.FDDTTGASI --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 43.07| 10| 51| 435| 444| 4 --------------------------------------------------------------------------- 288- 297 (20.91/11.43) CFFLKFPQPI 435- 444 (22.16/12.60) CFSISFQHPV --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) AQTEYSAEKHKKHKKEKKRLKDK 2) GVAKIIISKH 3) IKAKVTL 4) IPKITIQIPKGT 5) KKSYTMKPESWS 6) LMGDDDDLID 7) NKKPSLTAVIDKLKHGV 8) SKHGLGVGEFPTKRE | 1488 1386 1402 1051 1517 1559 1295 1340 | 1510 1395 1408 1062 1528 1568 1311 1354 |
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