<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31521

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCLELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAMYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLISKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGSNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEICSGSNKTKKKESSRLPPEKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPTTYPQPVPHPQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDCPAIGTPLRDSSSSGHSQSTLFDSDVFQTNNNENPYTDPADLIADAAGSPSSDSPTNHFFHDGVDFNPDLSNSQSQSGFGEEYFDESSQSGDNDDFKGFASQALNTLGVPMLGGDNGETKFKGNNQADTVDFSIISVAGKALAPADLMEHHSGSQGSLLTTGDLGKEKTQKRVKEGNGTSNSTLSGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSPSHSSSNRPFTPPTSTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYTSSGSVSSSGSKSHHSHSSSSSSSSASTSRKMKSSKSEGSSSSKLSSSMYSSQGSSGSSQSKNSSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTSSSSGMKSSSGLGSSGSLSQKTPPSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDPLDGQMGVSTNSSSHPMSSKHNMSGGEFQGKREKSDKDKSKVSTSGSSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKVKDKDRDRDRDKDRDKKKSHSIKPESWSKSPISSDQSLSMTSNTILSADRPSRLSPDFMIGEEDDDLMDVALIGN
Length1581
PositionMiddle
OrganismPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Pongo.
Aromaticity0.04
Grand average of hydropathy-0.679
Instability index54.11
Isoelectric point8.85
Molecular weight168581.17
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. Acts as a coactivator for GATA1-
mediated transcriptional activation during erythroid differentiation of
K562 erythroleukemia cells (By similarity).



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
DNA binding	GO:0003677	IEA:UniProtKB-KW
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
positive regulation of erythrocyte differentiation	GO:0045648	ISS:UniProtKB
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31521
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     181.05|      41|      41|     964|    1004|       1
---------------------------------------------------------------------------
  589-  633 (37.42/ 7.05)	VGHGEDFSKvSQNPILTSllqITGNGGSTIGSSPTP..PHHTPPPVS
  725-  763 (38.26/ 7.39)	DVNMTAD.T.LDTPHITP...APSQCS.TPTTYPQP..VPHPQPSIQ
  973- 1013 (66.58/19.02)	EGNGTSNST.LSGPGLDS...KPGKRSRTPSNDGKS..KDKPPKRKK
 1073- 1115 (38.80/ 7.61)	VGKPSSHSQ.YTSSGSVS...SSGSKSHHSHSSSSSssSASTSRKMK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     161.54|      22|      22|    1228|    1249|       2
---------------------------------------------------------------------------
 1018- 1038 (29.11/ 6.63)	GKSP..S.HSSSN..RPFTPPTSTGG
 1127- 1150 (31.00/ 7.64)	LSSSmySSQGSSG..SSQSKNSSQSG
 1221- 1242 (36.78/10.74)	AKSP..ISSGSGG..SHMSGTSSSSG
 1243- 1266 (33.90/ 9.20)	MKSS..SGLGSSGslSQKTPPSSNSC
 1267- 1288 (30.75/ 7.51)	TASS..SSFSSSG..SSMSSSQNQHG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     286.55|      50|      50|    1401|    1450|       3
---------------------------------------------------------------------------
 1180- 1220 (48.86/16.13)	.................SLMNPSLSK.PNISPSHS.RPPGGSDK.LASPMkpVPGTPPSSK......
 1330- 1365 (43.81/13.55)	............................GVSTNSSSHP.MSSKHNMSGGE..FQGKREKSDKDKSKV
 1401- 1450 (87.66/35.94)	SP...............SIKAKVTLQKPGESSGEGLRPQMASSKNYGSPL..ISGSTPKHERGSPSH
 1453- 1500 (47.77/15.57)	SPaytpqnldsesesgsSIAEKSYQNSP..SSDDGIRP...........L..PEYSTEKHKK....H
 1525- 1562 (58.46/21.03)	SH...............SIKPESWSKSP.ISSDQSL..SMTSN....TIL...SADRPS..RLSP..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.31|      13|      26|     327|     339|       4
---------------------------------------------------------------------------
  327-  339 (25.19/18.62)	IPLFETQPTYAPL
  355-  367 (25.12/18.54)	IPLNHNMRFYAAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      67.87|      21|      22|     876|     896|       6
---------------------------------------------------------------------------
  876-  893 (27.05/16.46)	..........GFGEEYFDES..SQSGDNDD
  894-  916 (22.37/11.93)	FKGfasqalnTLGVPML.......GGDNGE
  919-  937 (18.45/ 8.14)	FKG.......NNQADTVDFSiiSVAG....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     117.51|      31|      36|     800|     833|       7
---------------------------------------------------------------------------
  668-  700 (44.69/17.59)	RQNSSSGSPRMEIC.SGSNKTKKKESSrlpP......E..KP
  807-  848 (37.15/21.92)	RDSSSSGHSQSTLFDSDVFQTNNNENPytdPadliadAagSP
 1154- 1178 (35.66/14.28)	....GSSPITKHGLSSGSSSTKMK..P...Q......G..KP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.38|      16|      68|     302|     317|       8
---------------------------------------------------------------------------
  302-  317 (32.56/18.84)	CFFLKFPQPIPVSRAF
  373-  388 (29.83/16.56)	CYFLNKDAPLPDGRSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.16|      19|     247|     397|     423|       9
---------------------------------------------------------------------------
  405-  423 (34.06/36.13)	PLILNLIRHQVA..YNTLIGS
  643-  663 (31.10/12.27)	PMLMNLLKDNPAqdFSTLYGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.78|      31|     247|     509|     560|      10
---------------------------------------------------------------------------
  516-  560 (43.27/52.18)	ETIQAD.TPALSLIAEtvedmvkknlpPASS.PGygmTTGSNPMSGT
  772-  804 (48.51/18.36)	DSIGPDvTDILSDIAE...........EASKlPS...TSDDCPAIGT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.51|      27|     247|    1039|    1071|      11
---------------------------------------------------------------------------
 1039- 1071 (39.63/32.10)	SKSPGSSGRSQTPPgvATPPIPKitiqIPKGTV
 1289- 1315 (44.88/21.44)	SSKGKSPSRNKKPS..LTAVIDK....LKHGVV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.04|      31|      47|     216|     247|      12
---------------------------------------------------------------------------
  216-  247 (51.77/31.87)	GGHLMnLKYYVSP....SDLLDDK.TAS.PIILHENNV
  261-  297 (41.27/20.30)	GTSAM.YKLPIAPlimgSHPVDNKwTPSfSSITSANSV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31521 with Med1 domain of Kingdom Metazoa
Unable to open file!