<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31516
Description |
Mediator of RNA polymerase II transcription subunit 1 |
Sequence | MADQYVEVLGDLIGLLKDYKPGTITIENITKLCQSMGLESFIDELDNDISRLSTASKIIVIDIDYNKTQSTVQDVKLVLASNFDNFDYSNEQLEEAGDKQSNILLNSLTNYDSLKQFHHNLEFLYLLDTYSSVESDNQISSGNNLGSGNGTNGSSLTNKTDKKSVSSGNGLDSKLNEGKLNLFKYFRELKKYINTFFKESCDNRFKVVANVDNRFGLYIYETHGYSMRSRPLAKVYFERAKVPQQRFYEYIYSSETGSWINENSENYSVGVNLILEVNFDDTDEDVFWFPKEFVPTDLFIDEKDQLTSRKVSDVLCHAFYELGSSKKQTIELMNDFTTDLIQIRRFNINNDNLDLIADILNWTIWYRTVLRPIYLKLVSSISDDDDQHIRADIANTKDEFTVENTNPEIMKGPTNKNASFMQRNSMSLQRRRRSSNKAKRPSMSEAVVFKDEGLQQFSLHEIMADTTTEPDQKPDNLNISNNSESFIGQQELMEGSNIINDDKMDIDEEAINDDDSDSQSGEEGNIPVLLVNEDHVSFKGLGSCSFYDDKDKWAKFVEDLFNVFS |
Length | 565 |
Position | Middle |
Organism | Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes>
Saccharomycetales> Saccharomycetaceae> Nakaseomyces>
Nakaseomyces/Candida clade.
|
Aromaticity | 0.10 |
Grand average of hydropathy | -0.596 |
Instability index | 43.24 |
Isoelectric point | 4.57 |
Molecular weight | 64677.91 |
Publications | PubMed=15229592
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors (By similarity).
ECO:0000250
|
GO - Cellular Component | core mediator complex GO:0070847 IEA:EnsemblFungi
mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | negative regulation of transcription by RNA polymerase II GO:0000122 IEA:EnsemblFungi
positive regulation of transcription by RNA polymerase II GO:0045944 IEA:EnsemblFungi
|
Interaction
Repeat regions
Repeats |
>MDP31516
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 60.97| 20| 23| 128| 147| 1
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128- 147 (35.13/21.51) DTYS.SVESDNQ.ISSGNNLGS
152- 173 (25.84/13.90) NGSSlTNKTDKKsVSSGNGLDS
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 41.27| 11| 257| 41| 51| 4
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41- 51 (20.73/12.54) FIDELDNDISR
299- 309 (20.55/12.36) FIDEKDQLTSR
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|