<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31515
Description |
Mediator of RNA polymerase II transcription subunit 1 |
Sequence | MPDAYVESLGKMIAILVNYKPGSITLENITRLCQTMGLESFVDQVSANISRLSIASKIIVIDIDYEVTDGKVIDVKLVLASNFDKFDYFNGEANILHRSLTTYSDLHEFHHNLKFLTLLDACSSIDIESNVSQFDLFEYYSMLPQYMQSYLDDNGAQLTVQTNLNDRFGIYLLDHSEKKVAKLTFAATQDPNQRYYEYKYSSETKEWINQSAESYTTGITLVFELLGDPPTYLPKDSLPPEHPDEGFTSASASELQRRFAFKCQNPRVTLVNDFTVDVYPASTFQLLNDNICLCFDILRRQKWWHTVLYPISQLLLHQGQDSAVGDAPAPAAQPPLHRRRSSNKGCRRASAAESATLGDENMHQLTLTEIMNKSVIPEDDAMMDDRIELYVNENYVYLGTQEGCSFYNDPIERWEAFVESLRQMLT |
Length | 426 |
Position | Middle |
Organism | Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes>
Saccharomycetales> Saccharomycetaceae> Eremothecium.
|
Aromaticity | 0.11 |
Grand average of hydropathy | -0.322 |
Instability index | 50.38 |
Isoelectric point | 4.74 |
Molecular weight | 48583.11 |
Publications | PubMed=15001715
PubMed=23749448
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors (By similarity).
ECO:0000250
|
GO - Cellular Component | core mediator complex GO:0070847 IEA:EnsemblFungi
mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | negative regulation of transcription by RNA polymerase II GO:0000122 IEA:EnsemblFungi
positive regulation of transcription by RNA polymerase II GO:0045944 IEA:EnsemblFungi
|
Interaction
Repeat regions
Repeats |
>MDP31515
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 168.37| 54| 61| 171| 228| 1
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171- 228 (83.58/68.25) YLLDHS...EKKVAKLTfAATQDPNQRYYEYKYSSETKEWINQ.SAESYTTGitlVFELLGD
232- 289 (84.79/56.56) YLPKDSlppEHPDEGFT.SASASELQRRFAFKCQNPRVTLVNDfTVDVYPAS...TFQLLND
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 84.06| 24| 45| 81| 105| 2
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81- 105 (39.02/28.81) SNFDKFDYFNgEANILHRSLTTYSD
129- 152 (45.04/28.35) SNVSQFDLFE.YYSMLPQYMQSYLD
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