<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31514

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMSSIHSKVVIGEKRREMSSTAAGGSLPASIMANGSGKPIKMEMKPIVGTTAAGKGHGGLLPGSGDKHESWQMELLMERLRNKAKSSQYKSFQEMSKAVRMSLLEKRYALDAVEKSNLQKTLDSMQYCIKVTSRQGLVERLDCLTRQLGLKLSEDTSGLFISSDMFYLEIILDPNGTVQDVKVHHECKMKQQSCSELVSCLQRGDFVDFTTQLEGLASIYQLNAEKKIKVNAFVALQALETDLYNLYTLSTQHYNDIHSLLLKSPLGVVQKRRGGHAMKLTYYIAPYDLLDLEARKMKPLNTELISAEKIGYSVAVNLEASTANKLQIQPLLVQQGNSPVYSPIEKHNSTSLPATFVLRLNKPMALNVAMLKQIKHITGDSSAVTIDPATSNTCLMSLIVQHASNGTVNNIAKGLFVTLPDQYHCYYMTENKNLQGTIISSIPFTEPQHVSKILVFLRQQALFNQLLTSCIRNNGSSSTRMSDYEHLVVFEVAALSCQYITVSLEHPFEESIAMVEFDLRNILAIQVRVFCNGYESDERISKQVSLIVQRTMSIPVTLRGLMKIWQEDYEVKFKGQGNGGGNGTVDEGNFSLSMGPDEGGGNGPAGPGGGGGGGSAMNGQHNGSLNGSGMEFCDVKKVKLEPMDQSKKRRGVEDFCRSPKSSKVESEGGNEAMDEEDDDDEYDESTNLSSGDSNSLGENQQTNAGQSSSSTAAMGAPAPVSTVGPRNSVSGNASESSGNSSILGSLDFSSLDPDLMRSSNSSDLDDTTEVSEPEVKVKSEEPSYATSVSITPIGVGKSTSSLTNSVLNNIGLDKRPGIEIIPLANAGTNVPSSITITPIPMGSSGGSLKSSSDNSGDKKLSSSSSGSIHRKSGSSSSSSESDRAKLEKKKKRRHEEQLAQLQQMGPPHKILSKSTDGPASPSGSSRKFSVSPVPLKSGSGSSSSQIFLSSGSPGSGSKSSPKHSPVHHSSPKHQGSYGTSSPKHISGGSSGGGKPSMSALKSATSSGSPSSKNGSSGIGGSGKEEGSSGSGSKSSGSGGSSSSRDRDRDRDRDRGEKRSGYSSSSSSSSPKLKTPAVKLKQLDLTNCGSTVSAGVQLELMNSNSSGGSSSGSGSIDLTDSALFGIGATDLSKNASAAAASAAGMLLLQQAMKRKGSLSAVIDKLKSAQGGDESSLMLLPELAQQAGFSLKDASTPGKTASSSLPVASSSSASSSTSSTSVSNLTGASLGSASAAAAAALAAHFSSAAAAMQGKTSEYMVKPSSDGIKLTIQNKKGSKSGSSSSSTSSSSSKSSSSKSGTKPSISSGSLPPKKLPSSQSFSGAYPPTSGSSSSSSGKSFSSGSSSSSSSKAPFQKSSSSGSLSSSGSSMRPSSKSSTSSSGSSKDKSRSSSKSSSSSSAAAAAASSLMATNAAMAAAAQAAVNANALNVMKMLGLTSSIQNMEGFVKTLDTKFQIPKLSARSGGSSGSGPGGSDIEKLKQESRPLSSSSAPTTPLSNVGQSPTGSNDFSLPFNKLPGDVSPLHSTLLPNVMQKMFSGHDTSMLMRRSPNLDHQSSSNSRDGFSSIYGKGSTTPTTPTGSVPPPFPSPGNVQSHAMDFSNSSDSADASLMRPPSRPSSTMSNHSSSDKLIDATTNSNSMDGLRSTSPAQALAAAAVAAQLMNKLDNTQQFVAALKNHHHHLSALSLSNAAAVAASQLAAAAASASSGGSAGPGPVTSPTSVSVHIMKSPVPSPLPLHGGGGAASSSSVGGPDEDETLVGVSGK
Length1760
PositionMiddle
OrganismAedes aegypti (Yellowfever mosquito) (Culex aegypti)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Culicinae> Aedini> Aedes> Stegomyia.
Aromaticity0.04
Grand average of hydropathy-0.426
Instability index56.59
Isoelectric point9.09
Molecular weight181860.26
Publications
PubMed=17510324

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31514
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     205.99|      35|      35|     921|     955|       2
---------------------------------------------------------------------------
  910-  944 (56.46/15.87)	LSKSTDGPASPSGSSRKF.....SVS..........PV....PLKS..GSGSSSSQ
  945-  981 (43.10/10.10)	IFLSSGSPGSGSKSSPKH.....S............PVhhssPKHQ..GSYGTSSP
  982- 1011 (36.71/ 7.35)	KHISGGSSGGG.....KP.....SMS................ALKSatSSGSPSSK
 1202- 1235 (33.85/ 6.12)	LPVASSSSASSSTSST.......SVS..........NL....TGAS.lGSASAAAA
 1694- 1743 (35.88/ 6.99)	LAAAAASASSGGSAGPGPvtsptSVSvhimkspvpsPL....PLHG..GGGAASSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      99.72|      26|      27|    1087|    1112|       4
---------------------------------------------------------------------------
 1018- 1041 (35.83/ 9.08)	GGSGKEEGSSGSGSKSSGSGGSSS..
 1087- 1111 (32.95/ 7.60)	.GSTVSAGVQLELMNSNSSGGSSSGS
 1379- 1403 (30.93/ 6.56)	GSSKDKSRSS.SKSSSSSSAAAAAAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     122.89|      25|      27|     690|     714|       5
---------------------------------------------------------------------------
  574-  594 (27.23/10.31)	.......GQG..NG.GGNG..TVDEGNFSLSMG
  598-  625 (34.71/15.97)	GGGngpaGPG..GGGGGGS..AMN.GQHNGSLN
  687-  711 (36.66/17.44)	LSS....GDS..NSLGENQ..QTNAGQSSSSTA
  712-  740 (24.30/ 8.09)	AMG....APApvSTVGPRNsvSGNASESSGNSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.79|      23|      27|    1579|    1604|       6
---------------------------------------------------------------------------
 1271- 1293 (34.79/ 9.54)	NKKGS...KSGSSSSSTSSSSS....KSSS
 1583- 1612 (29.00/11.79)	PSPGNvqsHAMDFSNSSDSADAslmrPPSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.91|      27|      27|     831|     857|       7
---------------------------------------------------------------------------
  785-  813 (27.01/ 6.78)	TSVSITPIGVGKSTSSLTNSVlNNIGlDK
  831-  857 (50.91/19.99)	SSITITPIPMGSSGGSLKSSS.DNSG.DK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     128.71|      32|      32|    1464|    1495|       8
---------------------------------------------------------------------------
 1464- 1495 (57.30/21.54)	SGSGPGGSD.....IEKLKQESRPL..SSSS...............APTTPLSN
 1496- 1527 (40.63/13.20)	VGQSPTGSNdfslpFNKLPGDVSPL..HS....................TLLPN
 1529- 1574 (30.78/ 8.27)	MQKMFSGHD.....TSMLMRRSPNLdhQSSSnsrdgfssiygkgstTPTTP...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.69|      24|      27|      71|      94|       9
---------------------------------------------------------------------------
   71-   94 (41.41/31.37)	QMELLMER..LRNKAKSSQYKSFQEM
   99-  124 (34.28/24.47)	RMSLLEKRyaLDAVEKSNLQKTLDSM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.13|      16|      27|    1144|    1168|      10
---------------------------------------------------------------------------
 1144- 1168 (16.99/32.92)	LLL.....QQAmkrkG.SLsavidKLKSAQG
 1174- 1195 (20.15/ 9.86)	LMLlpelaQQA....GfSL.....KDASTPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.77|      13|      25|     628|     640|      11
---------------------------------------------------------------------------
  628-  640 (24.76/18.60)	GME.FC.DVKKVKLE
  650-  664 (16.00/ 8.84)	GVEdFCrSPKSSKVE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.69|      16|     185|     869|     884|      13
---------------------------------------------------------------------------
  869-  884 (28.53/10.12)	RKSG.SSSSSSESDRAK
 1056- 1072 (23.17/ 6.60)	KRSGySSSSSSSSPKLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.78|      11|      25|    1294|    1305|      14
---------------------------------------------------------------------------
 1294- 1305 (16.20/10.52)	SKSGTKPSiSSG
 1317- 1327 (22.58/10.83)	SFSGAYPP.TSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.82|      22|      25|    1621|    1642|      15
---------------------------------------------------------------------------
 1621- 1642 (35.53/22.66)	SSSDKLIDATTNSNSMDGLRST
 1643- 1664 (34.29/21.57)	SPAQALAAAAVAAQLMNKLDNT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.40|      21|      25|     205|     225|      17
---------------------------------------------------------------------------
  205-  225 (34.02/31.85)	FVDFTTQLEGLASIYQLNAEK
  232-  252 (34.38/32.29)	FVALQALETDLYNLYTLSTQH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.19|      15|      27|     286|     300|      18
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  286-  300 (25.71/18.31)	YDL.LDLEARKMKPLN
  311-  326 (19.48/11.91)	YSVaVNLEASTANKLQ
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31514 with Med1 domain of Kingdom Metazoa
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