<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31505

Description Isoform 2 of Mediator of RNA polymerase II transcription subunit 19
SequenceMENFTALFGAQADPPPPPTALGFGPGKPPPPPPPPAGGGPGTAPPPTAATAPPGADKSGAGCGPFYLMRELPGSTELTGSTNLITHYNLEQAYNKFCGKKVKEKLSNFLPDLPGMIDLPGSHDNSSLRSLIEKPPILSSSFNPITGTMLAGFRLHTGPLPEQCRLMHIQPPKKKNKHKHKQSRTQDPVPPETPSDSDHKKKKKKKEEDPDRKRKKKEKKKKKNRHSPDHPGMGSSQASSSSSLR
Length194
PositionHead
OrganismHomo sapiens (Human)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Homo.
Aromaticity0.05
Grand average of hydropathy-1.015
Instability index64.33
Isoelectric point9.83
Molecular weight26272.74
Publications
PubMed=15489334
PubMed=12584197
PubMed=15175163
PubMed=17081983
PubMed=18669648
PubMed=19413330
PubMed=19369195
PubMed=20068231
PubMed=23186163

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
transcription factor binding	GO:0008134	IBA:GO_Central

GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	IBA:GO_Central









Interaction





Binary Interactions
[A0JLT2<-->Q9NX70: MED29]	NbExp=8	EBI-394430,EBI-394656
[A0JLT2-2<-->Q86UW9: DTX2]	NbExp=3	EBI-13288755,EBI-740376
[A0JLT2-2<-->P62993: GRB2]	NbExp=3	EBI-13288755,EBI-401755
[A0JLT2-2<-->P50747: HLCS]	NbExp=3	EBI-13288755,EBI-3915568
[A0JLT2-2<-->Q63ZY3: KANK2]	NbExp=3	EBI-13288755,EBI-2556193
[A0JLT2-2<-->Q92993: KAT5]	NbExp=3	EBI-13288755,EBI-399080
[A0JLT2-2<-->Q8TAP4-4: LMO3]	NbExp=3	EBI-13288755,EBI-11742507
[A0JLT2-2<-->Q14511-2: NEDD9]	NbExp=3	EBI-13288755,EBI-11746523
[A0JLT2-2<-->P17252: PRKCA]	NbExp=3	EBI-13288755,EBI-1383528
[A0JLT2-2<-->Q0D2K3: RIPPLY1]	NbExp=3	EBI-13288755,EBI-10226430
[A0JLT2-2<-->Q15047-2: SETDB1]	NbExp=3	EBI-13288755,EBI-9090795
[A0JLT2-2<-->Q13148: TARDBP]	NbExp=3	EBI-13288755,EBI-372899
[A0JLT2-2<-->P61981: YWHAG]	NbExp=3	EBI-13288755,EBI-359832
[A0JLT2-2<-->P36508: ZNF76]	NbExp=3	EBI-13288755,EBI-7254550












Repeat regions





Repeats

>MDP31505
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      58.38|      12|      19|     199|     210|       2
---------------------------------------------------------------------------
  177-  191 (16.52/ 6.91)	HKHKQSRTQDpvpPE
  199-  210 (21.10/10.66)	KKKKKKKEED...PD
  218-  228 (20.77/10.39)	KKKKKNRH.S...PD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      84.05|      18|     115|     113|     130|       3
---------------------------------------------------------------------------
   68-   83 (22.81/11.40)	..MRELPGSTELTGSTNL
  113-  130 (34.83/21.06)	PGMIDLPGSHDNSSLRSL
  230-  243 (26.41/14.30)	PGM....GSSQASSSSSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.75|      15|      19|      29|      44|       4
---------------------------------------------------------------------------
   29-   43 (33.13/ 7.18)	PP....PPPPPAGGGPGTA
   45-   63 (24.63/ 6.77)	PPtaatAPPGADKSGAGCG
---------------------------------------------------------------------------











Associated diseases
Disease
prostate cancer	PMID:31715665 PMID:28125713
tongue cancer	PMID:23705783
breast cancer	PMID:30161287 PMID:27572702 PMID:20890603 PMID:30583076
gastric cancer	PMID:22565189
lung cancer	PMID:25735376
bladder cancer	PMID:21478038 PMID:23276457 PMID:28631286
cervical cancer	PMID:30473219
bone metastasis	PMID:23276457



























Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31505 with Med19 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ENFTALFGAQADPPPPPTALGFGPGKPPPPPPPPAGGGPGTAPPPTAATAPPGAD
2) FLPDLPGMIDLPGSHDNSSLRSLIEKPPILSSSFNPIT
3) TMLAGFRLHTGPLPEQCRLMHIQPPKKKNKHKHKQSRTQDPVPPETPSDSDHKKKKKKKEEDPDRKRKKKEKKKKKNRHSPDHPGMGSSQASSSSSLR
2
108
147
56
145
244










Molecular Recognition Features






MoRF SequenceStartStop




1) DSDHKKKKKKKEEDPDRKRKKKEKKKKKNRHSP
2) FGPGKP
3) MENFTAL
195
23
1
227
28
7