<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31504

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSCHPQTPQSPSQFSPNTSDLMMSMTGSVTSTTTTLPTPAHSVNGSSIPSELTQDTAMGDDSPHKRKRDGDDMGSRAQKKVHVEDRKLGIDDLHMDVGEKYLLCRTPHPRPRPHVSEDLFEMYGLTGLAIEVARVRPNGEKNALRKTYKGHIKRLGVQGHFDEDKQDPNREYSLSHLMKLPQDVWDLQHVRGQDIRDGFTNEVQQKLSRAMTMGRGVVPRDQWDSSVLGEMGPGKGERQALSARPTAPNTPLPSAGPQGLPRPKTGTPLMQDASRSMRTIKKRSYGDSSFEGYGESYDDGADTGYSTGEGDMSSGQKRRKKVLIND
Length326
PositionHead
OrganismChaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Sordariales> Chaetomiaceae> Chaetomium.
Aromaticity0.05
Grand average of hydropathy-0.959
Instability index48.87
Isoelectric point8.40
Molecular weight36015.86
Publications
PubMed=25720678

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). 
ECO:0000250
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP31504
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.47|      13|      23|     191|     207|       2
---------------------------------------------------------------------------
  191-  203 (23.66/19.12)	RGQDIRDGFTNEV
  215-  227 (24.81/ 9.63)	RGVVPRDQWDSSV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.15|      12|      16|     239|     252|       3
---------------------------------------------------------------------------
  239-  252 (13.71/15.61)	QALsARPTApNTPL
  258-  269 (24.44/13.63)	QGL.PRPKT.GTPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.09|      21|      98|       3|      27|       4
---------------------------------------------------------------------------
    3-   27 (30.03/28.71)	ChpQTPQsPSQfSPNTS.DL..MMSMTG
  104-  127 (36.06/17.57)	C..RTPH.PRP.RPHVSeDLfeMYGLTG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.52|      17|      27|      54|      76|       5
---------------------------------------------------------------------------
   46-   74 (19.61/16.97)	SS.ipseltQDTAMGDDSPHKrkrdgdDMG
   75-   98 (23.91/ 8.66)	SRaqkkvhvEDRKLGIDDLHM......DVG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31504 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DIRDGFTNEVQQKLSRAMTMGRGVVPRDQWDSSVLGEMGPGKGERQALSARPTAPNTPLPSAGPQGLPRPKTGTPLMQDASRSMRTIKKRSYGDSSFEGYGESYDDGADTGYSTGEGDMSSGQKRRKKVLIND
2) MSCHPQTPQSPSQFSPNTSDLMMSMTGSVTSTTTTLPTPAHSVNGSSIPSELTQDTAMGDDSPHKRKRDGDDMGSRAQKKVHVEDRKLGI
194
1
326
90










Molecular Recognition Features






MoRF SequenceStartStop




1) IKKRSYG
2) KYLLCR
3) MSSGQKRRKKVLIND
280
100
312
286
105
326