<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31500

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMFNNYGNVMMTDQFRKVEQYSPKSSPRAGGAGGRSPVVARQDSSGTLKTTIQLGKNPSIVHSGPFYLMKEPPGEGELTGATNLMAHYGLEHSYSKFSGKKVKEQLSSFLPNLPGVIDGPGHLDNSSLRSVIEKPPIGGKDLLPLTSVQLAGFRLHPGPLPEQYKHLKSVPTRKHKNKHKKHKYKEGVAPLSEQSALEASGLDTHEKKHKKQKRHEDDKERKKRKKEKKRKKQRHSPEHPGSGAASMPPQTQVF
Length253
PositionHead
OrganismAedes aegypti (Yellowfever mosquito) (Culex aegypti)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Culicinae> Aedini> Aedes> Stegomyia.
Aromaticity0.06
Grand average of hydropathy-1.036
Instability index54.00
Isoelectric point10.02
Molecular weight28086.74
Publications
PubMed=17510324

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). 
ECO:0000250
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats
>MDP31500
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     102.67|      22|      43|     161|     182|       1
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  161-  182 (39.85/19.06)	EQYKHLKSVPTRKHKNKHKKHK
  192-  209 (29.10/12.32)	EQ.SALEASGLDTHE...KKHK
  210-  230 (33.73/15.22)	KQKRH.EDDKERKKRKKEKKRK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31500 with Med19 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) RKVEQYSPKSSPRAGGAGGRSPVVARQDSSGTLKTTIQL
2) VQLAGFRLHPGPLPEQYKHLKSVPTRKHKNKHKKHKYKEGVAPLSEQSALEASGLDTHEKKHKKQKRHEDDKERKKRKKEKKRKKQRHSPEHPGSGAASMPPQTQVF
15
147
53
253










Molecular Recognition Features






MoRF SequenceStartStop




1) HKKHKYK
2) KKHKKQKRHEDDKERKKRKKEKKRKKQRHSPEHP
178
206
184
239