<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31491

Description Mediator of RNA polymerase II transcription subunit 18
SequenceMEAPPVTMMPVTGGTINMMEYLLQGSVLDHSLESLIHRLRGLCDNMEPETFLDHEMVFLLKGQQASPFVLRARRSMDRAGAPWHLRYLGQPEMGDKNRHALVRNCVDIATSENLTDFLMEMGFRMDHEFVAKGHLFRKGIMKIMVYKIFRILVPGNTDSTEALSLSYLVELSVVAPAGQDMVSDDMKNFAEQLKPLVHLEKIDPKRLM
Length208
PositionHead
OrganismHomo sapiens (Human)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Homo.
Aromaticity0.07
Grand average of hydropathy-0.118
Instability index38.06
Isoelectric point6.06
Molecular weight23662.45
Publications
PubMed=14702039
PubMed=16710414
PubMed=15489334
PubMed=12584197
PubMed=15175163
PubMed=15989967
PubMed=23186163

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IDA:MGI
ubiquitin ligase complex	GO:0000151	IEA:Ensembl

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central
ubiquitin protein ligase activity	GO:0061630	IEA:Ensembl

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central
termination of RNA polymerase II transcription	GO:0006369	IBA:GO_Central









Interaction





Binary Interactions
[Q9BUE0<-->Q63HM1: AFMID]	NbExp=3	EBI-394640,EBI-13286382
[Q9BUE0<-->Q13554: CAMK2B]	NbExp=3	EBI-394640,EBI-1058722
[Q9BUE0<-->Q8IX15-3: HOMEZ]	NbExp=3	EBI-394640,EBI-10172004
[Q9BUE0<-->Q9NVC6: MED17]	NbExp=3	EBI-394640,EBI-394562
[Q9BUE0<-->Q9H944: MED20]	NbExp=21	EBI-394640,EBI-394644
[Q9BUE0<-->Q15528: MED22]	NbExp=3	EBI-394640,EBI-394687
[Q9BUE0<-->Q9NX70: MED29]	NbExp=6	EBI-394640,EBI-394656
[Q9BUE0<-->O75586: MED6]	NbExp=3	EBI-394640,EBI-394624
[Q9BUE0<-->Q96N21: TEPSIN]	NbExp=3	EBI-394640,EBI-11139477
[Q9BUE0<-->Q9HCM9: TRIM39]	NbExp=3	EBI-394640,EBI-739510
[Q9BUE0<-->Q9HCM9-2: TRIM39]	NbExp=3	EBI-394640,EBI-11523450
[Q9BUE0<-->Q9R0X0: Med20]	Xeno	NbExp=6,












Repeat regions





Repeats

>MDP31491
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.50|      20|      70|      42|      63|       1
---------------------------------------------------------------------------
   42-   63 (33.96/24.00)	LCDNMEPETF.LDHEmvFLLKGQ
  114-  134 (34.54/18.41)	LTDFLMEMGFrMDHE..FVAKGH
---------------------------------------------------------------------------











Associated diseases
Disease


























Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31491 with Med18 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




NANANA









Molecular Recognition Features






MoRF SequenceStartStop




1) APWHLRYLG
81
89