<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31484

Description Mediator of RNA polymerase II transcription subunit 18
SequenceMVHQLSLVSSIPHNKYLQTISTLQALTGLIQPESISTYTLLAKPSYAFKPKFEPGKVNQIEQYYMRCITTWNSDKQGDDEKVEKGFDISEPFINKESNIVVRKLFTEEDSVERVWTLQVSDIPVAGKNQGCCQQQIYESTLVHTHTAIEIKVGNGDPIDIDTNNDKQGDNNTDKPKQEHDGKLPEAIDEDIIKNGDEKKTTHDDNDSDIMEIDEPNPETQTLPQSLSNGVSQRTTRKDSFLIFLSDLGYEVINQYWQKGVRFFYGDIIIEIYKIFIRDESSQADSNEGIKLKLLDDSNQFQIKAYININKSTEIDSINSGVKELIKLQEFLKNLFVLEIPDRMFMDSRIKQ
Length351
PositionHead
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Debaryomycetaceae> Candida/Lodderomyces clade> Candida.
Aromaticity0.08
Grand average of hydropathy-0.626
Instability index38.30
Isoelectric point4.79
Molecular weight40183.59
Publications
PubMed=15123810
PubMed=17419877
PubMed=24025428

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). 
ECO:0000250
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central
GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central
termination of RNA polymerase II transcription	GO:0006369	IBA:GO_Central

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP31484
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.26|      20|      90|      72|      91|       2
---------------------------------------------------------------------------
   72-   91 (36.47/20.04)	NSDKQGDD..EKVEKGFDISEP
  163-  184 (33.79/18.09)	NNDKQGDNntDKPKQEHDGKLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.08|      24|      88|     205|     230|       3
---------------------------------------------------------------------------
  205-  230 (36.89/23.56)	NDSDIMEIDEPNPEtqTLPQSLSNGV
  237-  260 (42.19/21.62)	KDSFLIFLSDLGYE..VINQYWQKGV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31484 with Med18 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) VGNGDPIDIDTNNDKQGDNNTDKPKQEHDGKLPEAIDEDIIKNGDEKKTTHDDNDSDIMEIDEPNPETQTLPQSLSNG
152
229










Molecular Recognition Features






MoRF SequenceStartStop




NANANA