<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31477
Description |
Mediator of RNA polymerase II transcription subunit 18 |
Sequence | MHELLLFASVPAHQHHELLQQLAGLTAMQPQHRFERRLIFKAYRKPGLVNVRVGASQDVQGAEMQRLNKMLNGGMFYTQVVGPVAAADFGAPAPTVSVGDQDAQMSGMGVGVSAGVDEKPSTRPHRYDYDDQPWKLEFRDIPEAGTRSAVTARLMASASLPRGDIMVPMNAWGYNFVTEYAVEGDIFILHDIVIFLHRVLHYPTESQEPRRQLPALPEMTPLERSGSYVLQAAITVQDGASQETMKIASQHLFGLREQLKSAVRLEMADRLSLDTRAK |
Length | 278 |
Position | Head |
Organism | Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes>
Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus>
Aspergillus subgen. Fumigati.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.266 |
Instability index | 43.48 |
Isoelectric point | 6.36 |
Molecular weight | 30904.98 |
Publications | PubMed=18404212
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors (By similarity).
ECO:0000250
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP31477
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 194.58| 61| 183| 1| 67| 1
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1- 67 (95.23/74.77) MHELLLFASVPAH...QHHELLQQLAGLTAMQPqhrFERRlifKAYRKPGLVNVRVGASQDVQGAEMQRL
189- 252 (99.35/62.27) LHDIVIFLHRVLHyptESQEPRRQLPALPEMTP...LERS...GSYVLQAAITVQDGASQETMKIASQHL
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