<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31476
Description |
Mediator of RNA polymerase II transcription subunit 18 |
Sequence | MVQQLSLYSVIDEGSFDLLIATISALSGRSPVLFANYNHVAHPNPNYAIEKVNAKNQLVEQTRVQLMQEIPFEKLQTEEYSYKLCTKMTGDGPPIETEYLNSLMRSCGDGTRPWSLSLWDIPSAGKDRKVCTQAVVESVVTSTGGAHSSILSFLAELGYVPGYQFVQLGTQFYLENGIVFQISKLWALHGESGKTSAVTKDGFLIKAYLNVPKATDLESINQGTAHLQQLKRELRDYLELSIPDRKSMDSRVGHLNDF |
Length | 258 |
Position | Head |
Organism | Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes>
Saccharomycetales> Saccharomycetaceae> Eremothecium.
|
Aromaticity | 0.09 |
Grand average of hydropathy | -0.223 |
Instability index | 35.61 |
Isoelectric point | 5.70 |
Molecular weight | 28726.29 |
Publications | PubMed=15001715
PubMed=23749448
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors (By similarity).
ECO:0000250
|
GO - Cellular Component | core mediator complex GO:0070847 IBA:GO_Central
mediator complex GO:0016592 IBA:GO_Central
|
GO - Biological Function | transcription coregulator activity GO:0003712 IBA:GO_Central
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IBA:GO_Central
termination of RNA polymerase II transcription GO:0006369 IBA:GO_Central
|
Interaction
Repeat regions
Repeats |
>MDP31476
No repeats found
|