<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31475

Description Mediator of RNA polymerase II transcription subunit 18
SequenceMSMECVVQGIIETQHVEALEILLQGLCGVQRERLRVHELCLRSGPNLGVVSSEVRLLCDLDQPEPTWTVKHVGGAMRGAGADQISVLVRNMIESKVSKNALRMFYALGYKLDHELLKVGFAFHFQRTAHISVSVSSVNKMPKVHAIDEAVPVTPGMQIVDVTAPATSENYSEVAAAVSSFCEFLAPLVHLSKPSISTGVVPTAAAAAASLMSDGGGTTL
Length219
PositionHead
OrganismArabidopsis thaliana (Mouse-ear cress)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Brassicales> Brassicaceae> Camelineae> Arabidopsis.
Aromaticity0.05
Grand average of hydropathy0.248
Instability index43.77
Isoelectric point6.05
Molecular weight23364.79
Publications
PubMed=10617197
PubMed=27862469
PubMed=17560376
PubMed=22021418
PubMed=24451981

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors (PubMed:22021418, PubMed:24451981). Involved in the regulation of histone H3 lysine tri-methylation (H3K36me3). Associates with the promoter, coding and terminator regions of target genes suggesting its function in transcription initiation, elongation and termination. Multifunctional protein which regulates plant immunity, especially during necrotrophic fungal infection (e.g. B.cinerea and A.brassicicola), flowering time and responses to hormones (e.g. abscisic acid ABA and ethylene) through interactions with distinct transcription factors (PubMed:24451981). 
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IDA:UniProtKB
nucleus	GO:0005634	IDA:UniProtKB

GO - Biological Function
transcription coregulator activity	GO:0003712	IMP:UniProtKB

GO - Biological Process
F:transcription coregulator activity	GO:0003712	IMUniProtKB
abscisic acid-activated signaling pathway	GO:0009738	IEA:UniProtKB-KW
carpel development	GO:0048440	IGI:TAIR
defense response	GO:0006952	IEA:UniProtKB-KW
ethylene-activated signaling pathway	GO:0009873	IEA:UniProtKB-KW
negative regulation of transcription, DNA-templated	GO:0045892	IMTAIR
petal development	GO:0048441	IGI:TAIR
production of miRNAs involved in gene silencing by miRNA	GO:0035196	IMTAIR
regulation of defense response to fungus	GO:1900150	IMUniProtKB
regulation of DNA-templated transcription, elongation	GO:0032784	IDA:UniProtKB
regulation of DNA-templated transcription, initiation	GO:2000142	IDA:UniProtKB
regulation of DNA-templated transcription, termination	GO:0031554	IDA:UniProtKB
regulation of histone H3-K36 trimethylation	GO:2001253	IMUniProtKB
regulation of photoperiodism, flowering	GO:2000028	IMUniProtKB
regulation of salicylic acid mediated signaling pathway	GO:2000031	IMTAIR
regulation of timing of transition from vegetative to reproductive phase	GO:0048510	IMTAIR
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central
regulation of transcription, DNA-templated	GO:0006355	IMUniProtKB
regulation of vernalization response	GO:0010219	IMTAIR
response to abscisic acid	GO:0009737	IMUniProtKB
response to ethylene	GO:0009723	IMUniProtKB
sepal development	GO:0048442	IGI:TAIR
specification of floral organ number	GO:0048833	IMTAIR
stamen development	GO:0048443	IGI:TAIR
termination of RNA polymerase II transcription	GO:0006369	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31475
No repeats found
No repeats found




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31475 with Med18 domain of Kingdom Viridiplantae
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