<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31470
Description |
Mediator of RNA polymerase II transcription subunit 17 |
Sequence | MSGVPAVNISIESSAEKQVQEVGLDGSETYVLPLSMSQNLARLAQRIDFSQESGEEEAEAARELEWAEQEEEEGLVKFQPSLWPWDSVRNNLRSTLTEMCVLYDVLNIVKEKRYMHLDPVSQEALPPKPNQHGLLLVSKKKSLAAAAQILLKGAERLSKSVAENQENKRQRDFNSELLRLRQHWKLRKLGDKILGDLSYRSAGSLFPHHGTFEVIKNTDIDLDKKMPEDYCPLDVHIPSDLEGSAYLKVSIQKQAPDIGDLGTVNLFRRPLPKAKPGTPHWQTRLEAAQNVLLCKEVFAQLSREAVQIKSQIPHIVVKNQIISQPFPGLQLSISLCHSSNDKKSQKSNSDKMGAEDHLYVLEHNLHQLIREFHKQTLSNIVMPHPASAPFGHKRMRLAGPQAFDKNEMGFMQQNEGLLEKIIKQAKHIFLRRRTARTIDSLASRIEDPQIQAHWSSINDVYESSVKVLITSQGYEQICKSIQLQLNIGVDQIRVVHRDGRVITLSHQEQELQDFLLSQMSQHQVLAVQQLAKVMGWHVLSFTNHVGLGQVESVGNASSITVTSPNGDYAISVRNGPESGTKVMVQFPRSQCKDLPKGDVLQENKWQYLRGPYKEVQWNKMEGRNFVYKMELLMAALTPC |
Length | 639 |
Position | Head |
Organism | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Amphibia>
Batrachia> Anura> Pipoidea> Pipidae> Xenopodinae> Xenopus> Silurana.
|
Aromaticity | 0.06 |
Grand average of hydropathy | -0.466 |
Instability index | 55.13 |
Isoelectric point | 7.70 |
Molecular weight | 72288.76 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors (By similarity).
ECO:0000250
|
GO - Cellular Component | core mediator complex GO:0070847 IBA:GO_Central
mediator complex GO:0016592 IBA:GO_Central
|
GO - Biological Function | transcription coregulator activity GO:0003712 IBA:GO_Central
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IBA:GO_Central
|
Interaction
Repeat regions
Repeats |
>MDP31470
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 115.40| 40| 145| 12| 53| 2
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12- 53 (60.09/50.30) ESSAEKQVQEVGLD.GSEtyVLPLSMSQNLARLAQRI..DFSQES
159- 201 (55.31/38.67) KSVAENQENKRQRDfNSE..LLRLRQHWKLRKLGDKIlgDLSYRS
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