<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31468
Description |
Mediator of RNA polymerase II transcription subunit 17 |
Sequence | MFSNGHFHIDLDPDAYGDANKDPFIQDEDKLTIAELIPRILIERNSFLNVTEESLQEEIDNPRAEDEANNEVDVASELDIGDESVENGSILMATLAETSLDPVELFQKQKLDLSKSINSALNETSLSLDFVSLLISSVKPNLAKSTISPHLNKSVPLGSLNSDRLSNENDDDDRNKSVAPKETPKVGHGWKLESLHKVTSLFREASENLNEQVLKERRYWNMINSVLTNDEVLFKTRDPLNNARAIGVKYGYGDSGSNFHDKGLAILRKDTVTGEISFNPINYAHKLTSKVFRYIRIKILSEIDGDFMLTGQSLFENDFSSSKDQIINDIEKARFFLFEEDLFYQLTREAKTLINYNVSIISNKIIIEINNEIIEIESVVYDENNDDELNNYYQNINAYSSINNGKCQLILKFFKIMLCCYYKYNLKLKQKIPTSLTKWKQSNSHPLVLRPLLGNIRHELNLKNMQSIIDRLIAKFKESLECKLQVDKFANLEHRSENPFQKSIERPVSKFNIVLKSKRSAYLKIDLELTTNEIFVNLIINMNVIKFKCEDDFKNNFNGVNVLQINFNDFHEIEECLDWTLLNFVNG |
Length | 587 |
Position | Head |
Organism | Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes>
Saccharomycetales> Debaryomycetaceae> Scheffersomyces.
|
Aromaticity | 0.09 |
Grand average of hydropathy | -0.420 |
Instability index | 36.84 |
Isoelectric point | 5.10 |
Molecular weight | 67457.52 |
Publications | PubMed=17334359
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors (By similarity).
ECO:0000250
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP31468
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 106.17| 33| 34| 425| 458| 1
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425- 458 (54.36/38.02) NLKLKQKIPTSL.TKWKQSNSHPLVLRPlLGNIRH
461- 494 (51.82/31.77) NLKNMQSIIDRLiAKFKESLECKLQVDK.FANLEH
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 38.43| 12| 25| 95| 106| 2
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95- 106 (21.93/12.58) LAET..SLDPVELF
121- 134 (16.50/ 7.92) LNETslSLDFVSLL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 57.19| 18| 30| 298| 315| 3
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298- 315 (30.95/18.31) KILSEID.GDFMLTGQSLF
325- 343 (26.24/14.47) QIINDIEkARFFLFEEDLF
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 45.25| 12| 30| 548| 559| 4
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548- 559 (24.66/13.66) KCEDDFKNNF.NG
575- 587 (20.59/10.28) ECLDWTLLNFvNG
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 51.00| 16| 31| 147| 162| 8
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147- 162 (27.68/20.58) ISPHLNKSVPLG.SLNS
178- 194 (23.33/16.12) VAPKETPKVGHGwKLES
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