<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31466
Description |
Mediator of RNA polymerase II transcription subunit 17 |
Sequence | MSGVRAVRISIESACEKQVQEVGLDGTETYLQPLSMSQNLARLAQRIDFSQGSGSEEEEAAGPDGDAPDWGGAGADQDDEEGLVKFQPSLWPWDSVRNNLRSALTEMCVLYDVLSIVRDKKFMTLDPVSQDALPPKQSPQTLQLISKKKSLAGAAQILLKGAERLTKSVAENQENKLQRDFNSELLRLRQHWKLRKVGDKILGDLSYRSAGSLFPHHGTFEVIKNTDIDLDKKIPEDYCPLDVQIPSDLEGSAYIKVSIQKQAPDIGDLGTVNLFKRPLPKSKPGSPHWQTKLEAAQNVLLCKEIFAQLSREAVQIKSQIPHIVVKNQIISQPFPSLQLSISLCHSSDDKKSQKCAAEKPGQEDHLYVLEHNLHLLIREFHKQTLSSIVMPHPASAPFGHKRMRLSGPQAFDKNEINSIQSTEGLLEKIIKQAKHIFLRSRTAATIDSLASRIEDPQIQAHWSNINDVYESSVKVLITSQGYEQICKSIQLQLNIGVEQVRVVHRDGRVIMLSHQEQELQDFLLSQMSQHQVHAVQQLAKVMGWQVLSFSNHVGLGPIESIGNASAITVASPSGDYAISVRNGPESGSKIMVQFPRNQCKDLPKSDVLQDSKWSHLRGPFKEVQWNKMEGRNFVYKMELLMSALSPCLL |
Length | 649 |
Position | Head |
Organism | Mus musculus (Mouse) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Muridae>
Murinae> Mus> Mus.
|
Aromaticity | 0.06 |
Grand average of hydropathy | -0.399 |
Instability index | 53.82 |
Isoelectric point | 6.86 |
Molecular weight | 72460.85 |
Publications | PubMed=16141072
PubMed=15489334
PubMed=12037571
PubMed=17132730
PubMed=21183079
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors (By similarity).
ECO:0000250
|
GO - Cellular Component | core mediator complex GO:0070847 IBA:GO_Central
mediator complex GO:0016592 IDA:MGI
nucleoplasm GO:0005654 TAS:Reactome
nucleus GO:0005634 ISO:MGI
transcription regulator complex GO:0005667 ISO:MGI
ubiquitin ligase complex GO:0000151 ISO:MGI
|
GO - Biological Function | nuclear receptor coactivator activity GO:0030374 ISO:MGI
thyroid hormone receptor binding GO:0046966 ISO:MGI
transcription coactivator activity GO:0003713 ISO:MGI
transcription coregulator activity GO:0003712 ISO:MGI
ubiquitin protein ligase activity GO:0061630 IEA:Ensembl
|
GO - Biological Process | positive regulation of transcription by RNA polymerase II GO:0045944 ISO:MGI
positive regulation of transcription initiation from RNA polymerase II promoter GO:0060261 ISO:MGI
positive regulation of transcription, DNA-templated GO:0045893 ISO:MGI
protein ubiquitination GO:0016567 ISO:MGI
regulation of transcription by RNA polymerase II GO:0006357 ISO:MGI
stem cell population maintenance GO:0019827 IMMGI
|
Interaction
Repeat regions
Repeats |
>MDP31466
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
4| 226.22| 51| 110| 278| 328| 1
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215- 260 (44.61/25.53) .................PHHGT.FEVIKNtdI.DLDKKIPEDYCPLDV..QIPSDLEgsaYIKVSIQ
278- 328 (89.00/58.37) PLPK.......SKP.GSPHWQTKLEAAQN..V.LLCKEIFAQLSREAV..QIKSQIP...HIVVKNQ
347- 392 (40.51/22.51) SDDKksqkcaaEKP.GQEDHLYVLE..HN..LhLLIREFHKQTLSSIV.......MP...H......
393- 441 (52.10/31.08) ..PA.......SAPfG..HKRMRLSGPQ...A.FDKNEINSIQSTEGLleKIIKQAK...HIFLRSR
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 87.03| 31| 339| 173| 207| 2
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173- 207 (40.82/40.05) QENKLQrDFnsELLRLRQHwKLRKVGD..KILG..DLSY
515- 549 (46.21/27.20) QEQELQ.DF..LLSQMSQH.QVHAVQQlaKVMGwqVLSF
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