<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31466

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMSGVRAVRISIESACEKQVQEVGLDGTETYLQPLSMSQNLARLAQRIDFSQGSGSEEEEAAGPDGDAPDWGGAGADQDDEEGLVKFQPSLWPWDSVRNNLRSALTEMCVLYDVLSIVRDKKFMTLDPVSQDALPPKQSPQTLQLISKKKSLAGAAQILLKGAERLTKSVAENQENKLQRDFNSELLRLRQHWKLRKVGDKILGDLSYRSAGSLFPHHGTFEVIKNTDIDLDKKIPEDYCPLDVQIPSDLEGSAYIKVSIQKQAPDIGDLGTVNLFKRPLPKSKPGSPHWQTKLEAAQNVLLCKEIFAQLSREAVQIKSQIPHIVVKNQIISQPFPSLQLSISLCHSSDDKKSQKCAAEKPGQEDHLYVLEHNLHLLIREFHKQTLSSIVMPHPASAPFGHKRMRLSGPQAFDKNEINSIQSTEGLLEKIIKQAKHIFLRSRTAATIDSLASRIEDPQIQAHWSNINDVYESSVKVLITSQGYEQICKSIQLQLNIGVEQVRVVHRDGRVIMLSHQEQELQDFLLSQMSQHQVHAVQQLAKVMGWQVLSFSNHVGLGPIESIGNASAITVASPSGDYAISVRNGPESGSKIMVQFPRNQCKDLPKSDVLQDSKWSHLRGPFKEVQWNKMEGRNFVYKMELLMSALSPCLL
Length649
PositionHead
OrganismMus musculus (Mouse)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Muridae> Murinae> Mus> Mus.
Aromaticity0.06
Grand average of hydropathy-0.399
Instability index53.82
Isoelectric point6.86
Molecular weight72460.85
Publications
PubMed=16141072
PubMed=15489334
PubMed=12037571
PubMed=17132730
PubMed=21183079

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). 
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IDA:MGI
nucleoplasm	GO:0005654	TAS:Reactome
nucleus	GO:0005634	ISO:MGI
transcription regulator complex	GO:0005667	ISO:MGI
ubiquitin ligase complex	GO:0000151	ISO:MGI

GO - Biological Function
nuclear receptor coactivator activity	GO:0030374	ISO:MGI
thyroid hormone receptor binding	GO:0046966	ISO:MGI
transcription coactivator activity	GO:0003713	ISO:MGI
transcription coregulator activity	GO:0003712	ISO:MGI
ubiquitin protein ligase activity	GO:0061630	IEA:Ensembl

GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	ISO:MGI
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	ISO:MGI
positive regulation of transcription, DNA-templated	GO:0045893	ISO:MGI
protein ubiquitination	GO:0016567	ISO:MGI
regulation of transcription by RNA polymerase II	GO:0006357	ISO:MGI
stem cell population maintenance	GO:0019827	IMMGI









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31466
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     226.22|      51|     110|     278|     328|       1
---------------------------------------------------------------------------
  215-  260 (44.61/25.53)	.................PHHGT.FEVIKNtdI.DLDKKIPEDYCPLDV..QIPSDLEgsaYIKVSIQ
  278-  328 (89.00/58.37)	PLPK.......SKP.GSPHWQTKLEAAQN..V.LLCKEIFAQLSREAV..QIKSQIP...HIVVKNQ
  347-  392 (40.51/22.51)	SDDKksqkcaaEKP.GQEDHLYVLE..HN..LhLLIREFHKQTLSSIV.......MP...H......
  393-  441 (52.10/31.08)	..PA.......SAPfG..HKRMRLSGPQ...A.FDKNEINSIQSTEGLleKIIKQAK...HIFLRSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.03|      31|     339|     173|     207|       2
---------------------------------------------------------------------------
  173-  207 (40.82/40.05)	QENKLQrDFnsELLRLRQHwKLRKVGD..KILG..DLSY
  515-  549 (46.21/27.20)	QEQELQ.DF..LLSQMSQH.QVHAVQQlaKVMGwqVLSF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31466 with Med17 domain of Kingdom Metazoa
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