<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31465

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMDGFSEYDPEKGIPLAIDPNLISIPVSTSLTTNGNGDEGVNNEDATVFAADDADNAKSQKSLIQNPYEYFGQMPLEQFIPLMLQQRGTGTKFADIHEETLLEEISRENSSKSNNAIQEEDNDDSAIQNVDEKTTTVVNEGVSDSHEMKDEDGDVNMDVPSVESSPKLAEEREPTADANDAQRAISGNQEESITLEEFKMIKKNVLEHVNMALNESSLSLEFVSLLLSSTRTSAGISSMSPYLKKIAPPASLNADKVPLDILDEHEKLTYDIIHKGWNLRSLEDCKRLLKQHYQILSKSVESEYHYWKQISDNITNKDVLFKMKDKNTGRRTLGIKYGFDDSGSCYSADKGIALLRATSEGSQLELVPIIDSGINVGISRGSSEQFVRVRIFTKIEQEDDYLLSGQSSLNELLLSSRSDIKSQIAKLRFFIFEKELMHQLKKEAGQLLPYGVSVENENKVLLELSNEKIEFELINLDEEVTSNYQQEAAKVNDKRANLILVMLNMLLVVMYKKQLWKRLNPNPHSSKSSKGYGKDLVLLRAILGKIRHKKYTQLIEKIVNNAILEKKEDSIMTTNTDITSNDNEPSKNKELATLQREIALFDKILSMPRTDFTINIPEKGKLELSLRSTNHCNAIIHMKYIDVGQVVKFDTRFSEFTEFEEFLNFVYNEFLI
Length671
PositionHead
OrganismKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Kluyveromyces.
Aromaticity0.07
Grand average of hydropathy-0.499
Instability index44.99
Isoelectric point4.96
Molecular weight75887.73
Publications
PubMed=15229592

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). 
ECO:0000250
GO - Cellular Component
core mediator complex	GO:0070847	IEA:EnsemblFungi
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
activating transcription factor binding	GO:0033613	IEA:EnsemblFungi
RNA polymerase II complex recruiting activity	GO:0001139	IEA:EnsemblFungi
RNA polymerase II core promoter sequence-specific DNA binding	GO:0000979	IEA:EnsemblFungi
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:EnsemblFungi

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP31465
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.59|      16|     270|     184|     208|       4
---------------------------------------------------------------------------
  184-  203 (23.93/26.22)	ISGNqeesITLEE..FKMIKKN
  309-  326 (25.66/ 7.84)	ISDN....ITNKDvlFKMKDKN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.07|      30|      95|     466|     497|       8
---------------------------------------------------------------------------
  466-  497 (39.95/33.64)	EKIEFELINLDEEVTSNyQQEAAKvNDKRANL
  564-  593 (50.11/31.53)	EKKEDSIMTTNTDITSN.DNEPSK.NKELATL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31465 with Med17 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) RGTGTKFADIHEETLLEEISRENSSKSNNAIQEEDNDDSAIQNVDEKTTTVVNEGVSDSHEMKDEDGDVNMDVPSVESSPKLAEEREPTADANDAQRAISGNQ
2) VSTSLTTNGNGDEGVNNEDATVFAADDADNAKSQKSLIQNP
86
26
188
66










Molecular Recognition Features






MoRF SequenceStartStop




1) LIQNPYEYFGQMPLEQFIPL
62
81