<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31464

Description Isoform 2 of Mediator of RNA polymerase II transcription subunit 17
SequenceMSGVRAVRISIESACEKQVHEVGLDGTETYLPPLSMSQNLARLAQRIDFSQGSGSEEEEAAGTEGDAQEWPGAGSSADQDDEEGVVKFQPSLWPWDSVRNNLRSALTEMCVLYDVLSIVRDKKFMTLDPVSQDALPPKQNPQTLQLISKKKSLAGAAQILLKGAERLTKSVTENQENKLQRDFNSELLRLRQHWKLRKVGDKILGDLSYRSAGSLFPHHGTFEVIKNTDLDLDKKIPEDYCPLDVQIPSDLEGSAYIKVSIQKQAPDIGDLGTVNLFKRPLPKSKPGSPHWQTKLEAAQNVLLCKEIFAQLSREAVQIKSQVPHIVVKNQIISQPFPSLQLSISLCHSSNDKKSQKFATEKQCPEDHLYVLEHNLHLLIREFHKQTLSSIMMPHPASAPFGHKRMRLSGPQAFDKNEINSLQSSEGLLEKIIKQAKHIFLRSRAAATIDSLASRIEDPQIQAHWSNINDVYESSVKVLITSQGYEQICKSIQLQLNIGVEQIRVVHRDGRVITLSYQEQELQDFLLSQMSQHQVHAVQQLAKVMGWQVLSFSNHVGLGPIESIGNASAITVASPSGDYAISVRNGPESGSKIMVQFPRNQCKDLPKSDVLQDNKWSHLRGPFKEVQWNKMEGRNFVYKMELLMSALSPCLL
Length145
PositionHead
OrganismHomo sapiens (Human)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Homo.
Aromaticity0.06
Grand average of hydropathy-0.414
Instability index54.73
Isoelectric point7.05
Molecular weight72889.29
Publications
PubMed=10198638
PubMed=10235266
PubMed=14702039
PubMed=16554811
PubMed=15489334
PubMed=9989412
PubMed=10235267
PubMed=12584197
PubMed=12509459
PubMed=15175163
PubMed=15989967
PubMed=16595664
PubMed=17525332
PubMed=18691976
PubMed=19369195
PubMed=20950787

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IDA:UniProtKB
membrane	GO:0016020	HDA:UniProtKB
nucleoplasm	GO:0005654	TAS:Reactome
nucleus	GO:0005634	IDA:UniProtKB
transcription regulator complex	GO:0005667	IDA:MGI

GO - Biological Function
nuclear receptor coactivator activity	GO:0030374	IDA:UniProtKB
thyroid hormone receptor binding	GO:0046966	IDA:UniProtKB
transcription coactivator activity	GO:0003713	IDA:UniProtKB
transcription coregulator activity	GO:0003712	IDA:UniProtKB
vitamin D receptor binding	GO:0042809	NAS:UniProtKB

GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	IDA:MGI
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IDA:UniProtKB
positive regulation of transcription, DNA-templated	GO:0045893	IDA:UniProtKB
regulation of transcription by RNA polymerase II	GO:0006357	IDA:MGI
regulation of transcription initiation from RNA polymerase II promoter	GO:0060260	TAS:Reactome
transcription initiation from RNA polymerase II promoter	GO:0006367	TAS:ProtInc









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31464
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     159.96|      53|     182|     290|     427|       1
---------------------------------------------------------------------------
  290-  343 (85.99/158.27)	HWQTKLEAAQNV.LLCKEIF.AQLSREAVQIkSQVPHIVVKNQIISQPFP......SLQLSI
  437-  497 (73.97/16.84)	HIFLRSRAAATIdSLASRIEdPQIQAHWSNI.NDVYESSVKVLITSQGYEqicksiQLQLNI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     214.38|      70|     339|     155|     248|       2
---------------------------------------------------------------------------
  175-  248 (111.09/113.50)	QENKLQrDFnsELLRLRQHwKLRKVGD..KILG..DLSYRSAGSLFPHH..GTFEVIKNTDLDLDKKI.....PEDYCPLDVQIP
  517-  597 (103.29/58.42)	QEQELQ.DF..LLSQMSQH.QVHAVQQlaKVMGwqVLSFSNHVGLGPIEsiGNASAITVASPSGDYAIsvrngPESGSKIMVQFP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.69|      34|     244|       1|      38|       3
---------------------------------------------------------------------------
    1-   38 (53.43/53.65)	MSGVRAVRISIesacEKQVHEVGLDGT.ETYLPPLSMSQ
  251-  285 (54.25/41.91)	LEGSAYIKVSI....QKQAPDIGDLGTvNLFKRPLPKSK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.85|      20|      20|      52|      71|       4
---------------------------------------------------------------------------
   52-   71 (35.51/20.43)	GSGSEEEEAAG.TEGDAQEWP
   74-   94 (32.34/18.02)	GSSADQDDEEGvVKFQPSLWP
---------------------------------------------------------------------------











Associated diseases
Disease


























Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31464 with Med17 domain of Kingdom Metazoa
Unable to open file!