<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31462
Description |
Mediator of RNA polymerase II transcription subunit 17 |
Sequence | MSNSVNISVETTCENQIREIGYDGTELYQPPPTLSESLAKCAARIDFSKTSLDDLKKEEKSAAAAADEDKDATQFQESLWPWDAVRNKLKDALTEICVLSDVISIAKDKRYLVLDPLLEEADDTKPIVQVYSRKKAISQAAQVLLSGAERLRNAHSEQRNRNVSDFHIELLRLRQNWRLKKVSNAIIGDLSYRTAGSKFGMSGTFEVTKAEETGDEDTASSSNSSSSVSGNNGMQLKASSALRVIVPAELQGVAYIKVITQKDQEDLCTAQLNLMGHGPNITAQVGVWQKTLEFAQNVLFCKELFAQLAREAIQLQAPIPHVVIGNQIRATLLPNIQLIISLCHSTTFDSSQPAPINDHDHVLEHSLHQLLREVHYKNSHHPFPHPASAPLGPTKKRMLAGPMAADRETLLDMTKSQTILEQIIAQAQHIFMRKRTQYVLDTLARDVKDPQIVSHWNAMNSPTMSCVKINIVTHGYDAIGRTSLVIHVKERSLKCICRDGRVMRLSYEPQELRDLILCQINSHQISCLISLARCMSWTVLSNSNHLGIGKVEPLGNASSCLLASPNSDRMIAVQIRCDPQIDVKVYIARSPRQDFFPSPLVPEKLWENLGGTFKEVRFDKIEGKSFLNKMEFLMASLTSNTA |
Length | 642 |
Position | Head |
Organism | Drosophila melanogaster (Fruit fly) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota>
Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea>
Drosophilidae> Drosophila> Sophophora.
|
Aromaticity | 0.05 |
Grand average of hydropathy | -0.279 |
Instability index | 43.72 |
Isoelectric point | 7.02 |
Molecular weight | 71556.05 |
Publications | PubMed=11090137
PubMed=10731132
PubMed=12537572
PubMed=12537569
PubMed=11511356
PubMed=11259581
PubMed=12021283
PubMed=16751183
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. Required for activated
transcription of the MtnA, MtnB and MtnD genes. Negatively regulates
sex comb development.
ECO:0000269 PubMed:11090137
ECO:0000269 PubMed:11259581
ECO:0000269 PubMed:12021283
ECO:0000269 PubMed:16751183
|
GO - Cellular Component | core mediator complex GO:0070847 IBA:GO_Central
mediator complex GO:0016592 IDA:UniProtKB
nucleus GO:0005634 IDA:FlyBase
pericentric heterochromatin GO:0005721 IPI:FlyBase
|
GO - Biological Function | activating transcription factor binding GO:0033613 IPI:FlyBase
transcription coregulator activity GO:0003712 IMP:UniProtKB
|
GO - Biological Process | F:transcription coregulator activity GO:0003712 IMUniProtKB
cellular process GO:0009987 IMFlyBase
positive regulation of transcription by RNA polymerase II GO:0045944 IMFlyBase
regulation of transcription by RNA polymerase II GO:0006357 IDA:FlyBase
regulation of transcription initiation from RNA polymerase II promoter GO:0060260 ISS:FlyBase
sex comb development GO:0045498 IGI:FlyBase
|
Interaction
Repeat regions
Repeats |
>MDP31462
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 173.06| 50| 161| 356| 407| 2
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356- 407 (83.49/59.01) INDHDHVLEHSLHQLLREVHYKNSHHpFPHPASAPLGPTKKRMLAGPmAADR
520- 569 (89.57/53.86) INSHQISCLISLARCMSWTVLSNSNH.LGIGKVEPLGNASSCLLASP.NSDR
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