<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31462

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMSNSVNISVETTCENQIREIGYDGTELYQPPPTLSESLAKCAARIDFSKTSLDDLKKEEKSAAAAADEDKDATQFQESLWPWDAVRNKLKDALTEICVLSDVISIAKDKRYLVLDPLLEEADDTKPIVQVYSRKKAISQAAQVLLSGAERLRNAHSEQRNRNVSDFHIELLRLRQNWRLKKVSNAIIGDLSYRTAGSKFGMSGTFEVTKAEETGDEDTASSSNSSSSVSGNNGMQLKASSALRVIVPAELQGVAYIKVITQKDQEDLCTAQLNLMGHGPNITAQVGVWQKTLEFAQNVLFCKELFAQLAREAIQLQAPIPHVVIGNQIRATLLPNIQLIISLCHSTTFDSSQPAPINDHDHVLEHSLHQLLREVHYKNSHHPFPHPASAPLGPTKKRMLAGPMAADRETLLDMTKSQTILEQIIAQAQHIFMRKRTQYVLDTLARDVKDPQIVSHWNAMNSPTMSCVKINIVTHGYDAIGRTSLVIHVKERSLKCICRDGRVMRLSYEPQELRDLILCQINSHQISCLISLARCMSWTVLSNSNHLGIGKVEPLGNASSCLLASPNSDRMIAVQIRCDPQIDVKVYIARSPRQDFFPSPLVPEKLWENLGGTFKEVRFDKIEGKSFLNKMEFLMASLTSNTA
Length642
PositionHead
OrganismDrosophila melanogaster (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.05
Grand average of hydropathy-0.279
Instability index43.72
Isoelectric point7.02
Molecular weight71556.05
Publications
PubMed=11090137
PubMed=10731132
PubMed=12537572
PubMed=12537569
PubMed=11511356
PubMed=11259581
PubMed=12021283
PubMed=16751183

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for activated transcription of the MtnA, MtnB and MtnD genes. Negatively regulates sex comb development. 
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IDA:UniProtKB
nucleus	GO:0005634	IDA:FlyBase
pericentric heterochromatin	GO:0005721	IPI:FlyBase

GO - Biological Function
activating transcription factor binding	GO:0033613	IPI:FlyBase
transcription coregulator activity	GO:0003712	IMP:UniProtKB

GO - Biological Process
F:transcription coregulator activity	GO:0003712	IMUniProtKB
cellular process	GO:0009987	IMFlyBase
positive regulation of transcription by RNA polymerase II	GO:0045944	IMFlyBase
regulation of transcription by RNA polymerase II	GO:0006357	IDA:FlyBase
regulation of transcription initiation from RNA polymerase II promoter	GO:0060260	ISS:FlyBase
sex comb development	GO:0045498	IGI:FlyBase









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31462
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     173.06|      50|     161|     356|     407|       2
---------------------------------------------------------------------------
  356-  407 (83.49/59.01)	INDHDHVLEHSLHQLLREVHYKNSHHpFPHPASAPLGPTKKRMLAGPmAADR
  520-  569 (89.57/53.86)	INSHQISCLISLARCMSWTVLSNSNH.LGIGKVEPLGNASSCLLASP.NSDR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31462 with Med17 domain of Kingdom Metazoa
Unable to open file!