<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31459

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMAGVPAVRISIESACEKQVQEVGLDGSETYLQPLSMSQNLARLAQRIDFSQGSGSEEDEPGSAGRAWAEPSEAEDEEGLVKFQPSLWPWDSVRNNLRSALTEMCVLYDVLSIVKDKKFMTLDPVVQDPPPPKQDPQFLQLISKKKSLAGAAQILLKGAERLSKSVAENQENKRQRDFNSELLRLRQHWKLRKVGDKILGDLSYRSAGSLFLHHGTFEVIKNTDIDLDKKIPEDYCPLDVQIPSDLEGSAYIKVSIQKQAPDIGDLGTVNLFKRPMPKSKPGTPHWQTKLETAQNVLLCKEIFAQLSREAVQIKSQIPHIVVKNQIISQPFPGLQLSISLCHSSNDKKSQKSASEKQNPEGHLYVLEHNLHQLIRECHKQTLSSVVMPHPASAPFGHKRMRLAGPQAFDKNEISSLQTNEGLLEKIIKQAKHIFLRRRTARTIDSLASRIEDPQIQAHWSNINDVYESSVKVLITSQGYEQICKSIQLQLNIGVEQIRVVHRDGRVITLSHQEQELQDFLLSQMSQHQVHAVQQLAKVMGWHVLSFSNHVGLGPVESIGNASAITVASPNGDYAISVRNGPESGSKVMVQFPRSQCKDLPKGDVLQDNKWNHLRGPFKEVQWNKMEGRNFVYKMELLMAALTPC
Length643
PositionHead
OrganismGallus gallus (Chicken)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Galloanserae> Galliformes> Phasianidae> Phasianinae> Gallus.
Aromaticity0.06
Grand average of hydropathy-0.457
Instability index54.44
Isoelectric point8.39
Molecular weight72128.56
Publications
PubMed=15642098

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). 
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	ISS:UniProtKB
nucleus	GO:0005634	ISS:AgBase
transcription regulator complex	GO:0005667	ISS:AgBase

GO - Biological Function
nuclear receptor coactivator activity	GO:0030374	ISS:UniProtKB
thyroid hormone receptor binding	GO:0046966	ISS:AgBase
transcription coactivator activity	GO:0003713	ISS:UniProtKB
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	ISS:AgBase
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	ISS:UniProtKB
positive regulation of transcription, DNA-templated	GO:0045893	ISS:AgBase
regulation of transcription by RNA polymerase II	GO:0006357	ISS:AgBase
transcription, DNA-templated	GO:0006351	ISS:AgBase









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31459
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     395.97|     138|     337|     149|     305|       1
---------------------------------------------------------------------------
  149-  305 (190.58/140.21)	GAAQIllKGAERLSKSVAENQENKRQRDFnsELLRLRQHwKLRKVGD..KILG..DLSYRSAGSLflhhGTFEVIKNTDIdLDKKIPE.DYCpldVQIPSDLEGSAYIKVSIQK.QAPDI..GDL...GTVNLFKRPMPKSKpgtphWqTKLETAQNVLLCKEIFAQL
  492-  640 (205.39/104.96)	GVEQI..RVVHRDGRVITLSHQEQELQDF..LLSQMSQH.QVHAVQQlaKVMGwhVLSFSNHVGL....GPVESIGNASA.ITVASPNgDYA...ISVRNGPESGSKVMVQFPRsQCKDLpkGDVlqdNKWNHLRGPFKEVQ.....W.NKMEGRNFVYKMELLMAAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     233.06|      70|     339|      10|      79|       2
---------------------------------------------------------------------------
   10-   79 (118.99/79.64)	SIESACEKQVQEVGLDGSETYLQPL...SMSQNLARLAQRIDFSQGSGSEEDE.PGSAGRAWAEPSEAEDEEGL
  348-  421 (114.07/76.04)	SQKSASEKQNPEGHLYVLEHNLHQLireCHKQTLSSVVMPHPASAPFGHKRMRlAGPQAFDKNEISSLQTNEGL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31459 with Med17 domain of Kingdom Metazoa
Unable to open file!