<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31459

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMAGVPAVRISIESACEKQVQEVGLDGSETYLQPLSMSQNLARLAQRIDFSQGSGSEEDEPGSAGRAWAEPSEAEDEEGLVKFQPSLWPWDSVRNNLRSALTEMCVLYDVLSIVKDKKFMTLDPVVQDPPPPKQDPQFLQLISKKKSLAGAAQILLKGAERLSKSVAENQENKRQRDFNSELLRLRQHWKLRKVGDKILGDLSYRSAGSLFLHHGTFEVIKNTDIDLDKKIPEDYCPLDVQIPSDLEGSAYIKVSIQKQAPDIGDLGTVNLFKRPMPKSKPGTPHWQTKLETAQNVLLCKEIFAQLSREAVQIKSQIPHIVVKNQIISQPFPGLQLSISLCHSSNDKKSQKSASEKQNPEGHLYVLEHNLHQLIRECHKQTLSSVVMPHPASAPFGHKRMRLAGPQAFDKNEISSLQTNEGLLEKIIKQAKHIFLRRRTARTIDSLASRIEDPQIQAHWSNINDVYESSVKVLITSQGYEQICKSIQLQLNIGVEQIRVVHRDGRVITLSHQEQELQDFLLSQMSQHQVHAVQQLAKVMGWHVLSFSNHVGLGPVESIGNASAITVASPNGDYAISVRNGPESGSKVMVQFPRSQCKDLPKGDVLQDNKWNHLRGPFKEVQWNKMEGRNFVYKMELLMAALTPC
Length643
PositionHead
OrganismGallus gallus (Chicken)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Galloanserae> Galliformes> Phasianidae> Phasianinae> Gallus.
Aromaticity0.06
Grand average of hydropathy-0.457
Instability index54.44
Isoelectric point8.39
Molecular weight72128.56
Publications
PubMed=15642098

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). 
ECO:0000250
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	ISS:UniProtKB
nucleus	GO:0005634	ISS:AgBase
transcription regulator complex	GO:0005667	ISS:AgBase
GO - Biological Function
nuclear receptor coactivator activity	GO:0030374	ISS:UniProtKB
thyroid hormone receptor binding	GO:0046966	ISS:AgBase
transcription coactivator activity	GO:0003713	ISS:UniProtKB
transcription coregulator activity	GO:0003712	IBA:GO_Central
GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	ISS:AgBase
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	ISS:UniProtKB
positive regulation of transcription, DNA-templated	GO:0045893	ISS:AgBase
regulation of transcription by RNA polymerase II	GO:0006357	ISS:AgBase
transcription, DNA-templated	GO:0006351	ISS:AgBase

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP31459
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     395.97|     138|     337|     149|     305|       1
---------------------------------------------------------------------------
  149-  305 (190.58/140.21)	GAAQIllKGAERLSKSVAENQENKRQRDFnsELLRLRQHwKLRKVGD..KILG..DLSYRSAGSLflhhGTFEVIKNTDIdLDKKIPE.DYCpldVQIPSDLEGSAYIKVSIQK.QAPDI..GDL...GTVNLFKRPMPKSKpgtphWqTKLETAQNVLLCKEIFAQL
  492-  640 (205.39/104.96)	GVEQI..RVVHRDGRVITLSHQEQELQDF..LLSQMSQH.QVHAVQQlaKVMGwhVLSFSNHVGL....GPVESIGNASA.ITVASPNgDYA...ISVRNGPESGSKVMVQFPRsQCKDLpkGDVlqdNKWNHLRGPFKEVQ.....W.NKMEGRNFVYKMELLMAAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     233.06|      70|     339|      10|      79|       2
---------------------------------------------------------------------------
   10-   79 (118.99/79.64)	SIESACEKQVQEVGLDGSETYLQPL...SMSQNLARLAQRIDFSQGSGSEEDE.PGSAGRAWAEPSEAEDEEGL
  348-  421 (114.07/76.04)	SQKSASEKQNPEGHLYVLEHNLHQLireCHKQTLSSVVMPHPASAPFGHKRMRlAGPQAFDKNEISSLQTNEGL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31459 with Med17 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




NANANA









Molecular Recognition Features






MoRF SequenceStartStop




1) LARLAQRIDF
40
49