<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31446
Description |
Mediator of RNA polymerase II transcription subunit 16 |
Sequence | MMLGEHLMSWSKTGIIAYSDSQSSNANICLTFLESINGINWRFHTPQKYVLHPQLHEVQYQESSSTLSTHSTTTSVNGSTTAGVGSTPNFGGNSNKSPPQFFYNISSIHWNNWFSLPGDMLAVCDELGNMTMLITGQRPDRATTYEKLTMVFQDNVYKIYNHVMPLKPVDKLKPMNIERKQTRKEYNTSILEFRWLTSSKSVIVSQFCAFDSSSNTYRSRAQQVPPYGVYHPPFIKYACLAIRKNGQIDFWYQFSNSKDHKKITLQLLDTSNQRFKDLQWLEFARITPMNDDQCMLITTYSKLSKNISFYKLHVNWNLNATKPNVLNDPSLKIQFILSTTLDPTDDEGHVLKLENLHVVSKSSIEKDPSPEILVLYNVCDTSKSLVKRYRLAPTQLSAEYLVILKPDLNIDRNNSTNQIFQSRRYNLRRHSDIVLDKKVTLITSEMFDAFVSFYFEDGTIESYNQNDWKLETERLISQSQLGKFKNIIASPLSAGFNYGKLPLPPSVEWMKVSPSMCGVIVKQYNKKWPQFYAAVQKNYADPEKDSINATALAFGYVKSLHKQISAEDLTIAAKTHILRISFLDRKRAKEFITTLLKSLYSFFNISPDAPKEIMDKIITSRPLQKIMLLQLELGSCFSQENIEEMARVILYLKNVLFAFNGVARNFHFAIEQISNNSNQQQNPKLFQTIFSKQDLIHSLIPVAKWFVKFITYLTQEILILINDPTNKEYTLVHGIFGAKMSRTLILSILNEIKKVTQIVAKFPETSYPILNESSTFLKLVLSESPVDFEKFETFLVDVNNKFIALCEQQPSQEREFSLLVKAEIPPEYAKVGDFLLQYANNAVISHANAAAVYFADTSGLKISNSEFFNPEIFHLLQPLEEGLIIDTDKLPIKNRTSKSFSKLLYDDVTCDKLSVSEISDGKLKRCSRCGSVTRAGNIISSDKTIVPTSIQTKRWPTMYTRLCICSGMLFEMDG |
Length | 974 |
Position | Tail |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes>
Saccharomycetales> Saccharomycetaceae> Saccharomyces.
|
Aromaticity | 0.11 |
Grand average of hydropathy | -0.256 |
Instability index | 46.19 |
Isoelectric point | 8.76 |
Molecular weight | 111295.41 |
Publications | PubMed=8423805
PubMed=1406639
PubMed=8896273
PubMed=9169873
PubMed=24374639
PubMed=7479899
PubMed=12743037
PubMed=14562095
PubMed=14562106
PubMed=15175151
PubMed=14749387
PubMed=15477388
PubMed=16002404
PubMed=16076843
PubMed=16109375
PubMed=16263706
PubMed=17192271
PubMed=12191485
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. The Mediator complex, having a compact
conformation in its free form, is recruited to promoters by direct
interactions with regulatory proteins and serves for the assembly of a
functional preinitiation complex with RNA polymerase II and the general
transcription factors. The Mediator complex unfolds to an extended
conformation and partially surrounds RNA polymerase II, specifically
interacting with the unphosphorylated form of the C-terminal domain
(CTD) of RNA polymerase II. The Mediator complex dissociates from the
RNA polymerase II holoenzyme and stays at the promoter when
transcriptional elongation begins.
ECO:0000269 PubMed:16076843
ECO:0000269 PubMed:16109375
ECO:0000269 PubMed:16263706
|
GO - Cellular Component | core mediator complex GO:0070847 IDA:SGD
mediator complex GO:0016592 IDA:SGD
|
GO - Biological Function | RNA polymerase II activating transcription factor binding GO:0001102 IDA:SGD
|
GO - Biological Process | negative regulation of transcription by RNA polymerase II GO:0000122 IMSGD
positive regulation of transcription by RNA polymerase II GO:0045944 IMSGD
regulation of establishment of protein localization to chromosome GO:0070202 IMSGD
RNA polymerase II preinitiation complex assembly GO:0051123 IMSGD
|
Interaction
Repeat regions
Repeats |
>MDP31446
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 92.66| 28| 150| 35| 66| 3
---------------------------------------------------------------------------
35- 66 (43.23/44.82) SIngINWRFHTPQKYVLHPQLheVQYQESSST
189- 216 (49.43/34.69) SI..LEFRWLTSSKSVIVSQF..CAFDSSSNT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 51.40| 15| 150| 134| 148| 4
---------------------------------------------------------------------------
134- 148 (28.07/19.30) ITGQRPDR...ATTYEKL
286- 303 (23.33/14.75) ITPMNDDQcmlITTYSKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 42.64| 12| 36| 322| 333| 5
---------------------------------------------------------------------------
322- 333 (21.40/12.63) KPNVLNDPSLKI
361- 372 (21.24/12.48) KSSIEKDPSPEI
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 85.71| 25| 37| 776| 800| 11
---------------------------------------------------------------------------
776- 800 (42.37/31.45) FLKLVLSESPVDFEKFETFLVDVNN
816- 840 (43.34/32.35) FSLLVKAEIPPEYAKVGDFLLQYAN
---------------------------------------------------------------------------
|