<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31444

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMDVGYVCEWDKRPRTSHCPSIPLVCAWSCRNLIAFTTDQRNEEEKDITNLIHILDTEHPWDVYSINSGHQEVITSLEWDQSGSRLLSADADGRIKCWGMTDHLANSWQSLVGSEVDGDPIVALSWLHNGVKLALHVEKSGVSSFGEKFSRVKFSPSLTLFGGKPMEGWIAVTVSGLVTVSLLKPNGQVLTATESLCRLRCRVALADIAFTGGGNIVVATCDGSSTSPVQFYKVCVSVVSEKCKIDTEILPSLFMRCTTDPARKDKFPAVTHLKFLARDMSEQVLLCASNQCSSIAECWSLRKEGLPLNNIFQQLSPAVSDKQPMILKWRILSATNELERVSAVALPKLPISLTNTDIKVASETKFYPGLGLALAFHDGNVQIVHRLSLQPMAVLYGSSLRPSEEPSLKRQRSPTPCIHFKALQMSWTSLALVGLDTQGKLSMLRVSPSMGHSLDMSTSLRHLLFLLEYCMVTGYDWWDILLHVQPGMVHNLVEKLNEEYTRQNAALQQVLSTRILAMKASLCKLSQTTVTRVCDYHAKLFLISISCTLKSLLRPHVLNTPDKSPGDRLTEICNKFTDTDIDKVMINLKTEEFVLDMPTLQSLQQLIQWLGDFVLYLLASLPNQGSSVRPGHSFLRDGASLGTLREMMVMIRIWGLLKPSCLPVYTATSDTQDSMSLLFRLLTRLWLCCRDESHPCDPDESLIDECCLLPSQLLIPNMDWLPLGNGIISRLQSKLPLRLQFGKPPVAPSYASVQYEAYTRSPTQPKIDHLRRLHLGTFPTEPCKSCTRCGCVTMLKSPNKATAVKQWEQRWIKTCLCGGLWRKMPHTYS
Length828
PositionTail
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Amphibia> Batrachia> Anura> Pipoidea> Pipidae> Xenopodinae> Xenopus> Silurana.
Aromaticity0.07
Grand average of hydropathy-0.058
Instability index49.88
Isoelectric point8.28
Molecular weight92539.47
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors (By similarity). 


GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
GO - Biological Process
positive regulation of transcription, DNA-templated	GO:0045893	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31444
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     220.39|      66|      96|     249|     316|       1
---------------------------------------------------------------------------
  249-  316 (115.12/73.79)	LPSLFMRCT.TD..PARKDKFPAVTHLKFLARDMSEQVLLCASNQCSSIAECWSLRKEGLPlnNIFQQLSP
  345-  413 (105.27/61.94)	LPKLPISLTnTDikVASETKFYPGLGLALAFHDGNVQIVHRLSLQPMAVLYGSSLRPSEEP..SLKRQRSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     181.36|      58|     492|     105|     182|       3
---------------------------------------------------------------------------
  105-  182 (82.15/89.30)	NSWQSLVgsevdgdpivalSWLHNGVKLALhveksgvSSFGEKFSRVKFSPSLtLFGGKPM....EGWIAVTVSGLVTVSLL
  600-  661 (99.21/61.88)	QSLQQLI............QWLGDFVLYLL.......ASLPNQGSSVRPGHSF.LRDGASLgtlrEMMVMIRIWGLLKPSCL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.04|      10|     500|      52|      61|      10
---------------------------------------------------------------------------
   52-   61 (20.38/11.92)	HILDTEHPWD
   70-   79 (17.66/ 9.35)	QEVITSLEWD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31444 with Med16 domain of Kingdom Metazoa
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