<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31439

Description Isoform 5 of Mediator of RNA polymerase II transcription subunit 16
SequenceMCDLRRPAAGGMMDLAYVCEWEKWSKSTHCPSVPLACAWSCRNLIAFTMDLRSDDQDLTRMIHILDTEHPWDLHSIPSEHHEAITCLEWDQSGSRLLSADADGQIKCWSMADHLANSWESSVGSLVEGDPIVALSWLHNGVKLALHVEKSGASSFGEKFSRVKFSPSLTLFGGKPMEGWIAVTVSGLVTVSLLKPSGQVLTSTESLCRLRGRVALADIAFTGGGNIVVATADGSSASPVQFYKVCVSVVSEKCRIDTEILPSLFMRCTTDLNRKDKFPAITHLKFLARDMSEQVLLCASSQTSSIVECWSLRKEGLPVNNIFQQISPVVGDKQPTILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLGLALAFHDGSVHIVHRLSLQTMAVFYSSAAPRPVDEPAMKRPRTAGPAVHLKAMQLSWTSLALVGIDSHGKLSVLRLSPSMGHPLEVGLALRHLLFLLEYCMVTGYDWWDILLHVQPSMVQSLVEKLHEEYTRQTAALQQVLSTRILAMKASLCKLSPCTVTRVCDYHTKLFLIAISSTLKSLLRPHFLNTPDKSPGDRLTEICTKITDVDIDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFVLYLLASLPNQGSLLRPGHSFLRDGTSLGMLRELMVVIRIWGLLKPSCLPVYTATSDTQDSMSLLFRLLTKLWICCRDEGPASEPDEALVDECCLLPSQLLIPSLDWLPASDGLVSRLQPKQPLRLQFGRAPTLPGSAATLQLDGLARAPGQPKIDHLRRLHLGACPTEECKACTRCGCVTMLKSPNRTTAVKQWEQRWIKNCLAVEGRGPDACVTSRASEEAPAFVQLGPQSTHHSPRTPRSLDHLHPEDRP
Length663
PositionTail
OrganismHomo sapiens (Human)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Homo.
Aromaticity0.06
Grand average of hydropathy-0.008
Instability index51.16
Isoelectric point7.12
Molecular weight96792.11
Publications
PubMed=10198638
PubMed=10235266
PubMed=15489334
PubMed=15175163
PubMed=15989967

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000269	PubMed:10198638
ECO:0000269	PubMed:10235266
GO - Cellular Component
mediator complex	GO:0016592	IDA:UniProtKB
membrane	GO:0016020	HDA:UniProtKB
nucleoplasm	GO:0005654	TAS:Reactome
nucleus	GO:0005634	NAS:UniProtKB
GO - Biological Function
catalytic activity	GO:0003824	IEA:InterPro
thyroid hormone receptor binding	GO:0046966	IDA:UniProtKB
transcription coactivator activity	GO:0003713	IDA:UniProtKB
vitamin D receptor binding	GO:0042809	NAS:UniProtKB
GO - Biological Process
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IDA:UniProtKB
positive regulation of transcription, DNA-templated	GO:0045893	IDA:UniProtKB
regulation of transcription by RNA polymerase II	GO:0006357	NAS:UniProtKB
regulation of transcription initiation from RNA polymerase II promoter	GO:0060260	TAS:Reactome
transcription by RNA polymerase II	GO:0006366	TAS:ProtInc

Interaction

Binary Interactions
[Q9Y2X0<-->O60244: MED14]	NbExp=2	EBI-394541,EBI-394489
[Q9Y2X0<-->Q9ULK4: MED23]	NbExp=4	EBI-394541,EBI-311161
[Q9Y2X0<-->O75448: MED24]	NbExp=2	EBI-394541,EBI-394523
[Q9Y2X0<-->Q71SY5: MED25]	NbExp=3	EBI-394541,EBI-394558

Repeat regions

Repeats

>MDP31439
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.24|      27|     132|      22|      48|       1
---------------------------------------------------------------------------
   22-   48 (53.17/31.49)	EKWSKSTHCPSVPLACAWSCRNLIAFT
  157-  183 (49.06/28.47)	EKFSRVKFSPSLTLFGGKPMEGWIAVT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     102.00|      22|      32|     743|     764|       2
---------------------------------------------------------------------------
  721-  741 (29.03/12.06)	.PS.QLL.IPSLDWLPASDGLVSR
  743-  764 (39.65/18.95)	QPK.QPL.RLQFGRAPTLPGSAAT
  776-  799 (33.32/14.85)	QPKiDHLrRLHLGACPTEECKACT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.29|      12|      27|      89|     100|       3
---------------------------------------------------------------------------
   89-  100 (21.77/11.00)	WDQSGSRLLSAD
  118-  129 (21.52/10.80)	WESSVGSLVEGD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     143.63|      45|     195|     279|     325|       4
---------------------------------------------------------------------------
  279-  325 (70.45/50.43)	AITHLKFL.......ARDMSEQVLLCASSQTSSIVEcwSLRKEGLPVNNIFQQI
  470-  521 (73.19/44.12)	ALRHLLFLleycmvtGYDWWDILLHVQPSMVQSLVE..KLHEEYTRQTAALQQV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.57|      19|      74|     551|     569|       7
---------------------------------------------------------------------------
  551-  569 (34.22/21.53)	LFLIAISSTLKSLLRP.H.FL
  626-  646 (27.35/15.67)	LYLLASLPNQGSLLRPgHsFL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.96|      25|      35|     647|     674|      10
---------------------------------------------------------------------------
  647-  674 (42.06/30.93)	RDGTSL..GMLRELMVVIRIWGllkPSCLP
  683-  709 (42.90/24.34)	QDSMSLlfRLLTKLWICCRDEG...PASEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.71|      11|      36|     537|     550|      11
---------------------------------------------------------------------------
  537-  550 (17.44/19.98)	SPC.TVTRVCdyhTK
  575-  586 (17.27/ 8.37)	SPGdRLTEIC...TK
---------------------------------------------------------------------------

Associated diseases

Disease
papillary thyroid cancer	PMID:32532820


Explaination for Stockholm format The "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space.

#=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00)

#=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column. It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column. This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.

#=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.

Alignment of MDP31439 with Med16 domain of Kingdom Metazoa



     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) CVTSRASEEAPAFVQLGPQSTHHSPRTPRSLDHLHPEDRP
838
877










Molecular Recognition Features






MoRF SequenceStartStop




NANANA