<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31437

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMTILYKVEGKEFSKDSVFPHKKVLCSVSARNIVAFSALQSAIFPASHGGDAGDGSLPGAGLAVGASNSHVYVCDIVTPWEYYKVCSSKSLISVLQWSPNGEQLLLGYVGGRVEIWQPRNQSINLWVLQYYATVPSEDIIEAQFFQNGKGVIFNALKKDHTYYAEKFERVEQQRPTLSGFGGVASEGCVLLTSSGLLAAFSLPAIQKTSAAGADGPAHEVVELTPALHSIGISRSFIEHCSMTPSPSGALNIAFSCGWQQQLVQCFKVSLSLEGELGLEQHLAIKSESQTSIFLGPLDGRRISHLKWTRIANEDVIFIAYACPDGAGSQLEQWTLTRRHQSVHALLQGGGGANNKPNEFVQSESWEQVGKVQLNASLADISVTRLSVSTPDSCQVYAILQDNSVQVLEPNSMKQLNHTQFDRLSDASGAVKFVSGDLTPSSQILLIFDSHAQLYAMQAPLPKQGGSGLLLLEYCIVTGCDASDVLLLNLGNLEALVEKLTDNFTRQPSFVRHFYYANFLALKSNICRMQQQEFDNLIILHAISTTFKSLLRPSDLGFQDKGPADNLAIKLAESIPDVDTVMLNLDAKDFTVEPVMLQSLQQLIQWVTDLALNMLHRLPEEVMKTKLSGKRPSYDISRDIVAISSLRELLVMIRIWGLLNTQCLPVYTKTMDNIDVLVILFRLLTRLAQNPAEPDEMLLDECSLLSKQLLIPQPTKFNPTTLLSAQGFAAVKSGQLQFTSMEEPTCLQDMETEEVVFASSVKDGVSNLQLGARPSHIRRCARCGFVFVNNASKVAKTSALKAWFSKWLHCHCGGFWKQVH
Length818
PositionTail
OrganismDrosophila melanogaster (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.08
Grand average of hydropathy0.000
Instability index45.99
Isoelectric point6.01
Molecular weight89978.09
Publications
PubMed=10731132
PubMed=12537572
PubMed=12537569
PubMed=15297616
PubMed=16751183

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for activated transcription of the MtnA, MtnB and MtnD genes. Required for transcriptional activation in response to lipopolysacchardie (LPS). 
GO - Cellular Component
mediator complex	GO:0016592	IDA:UniProtKB

GO - Biological Function
transcription coregulator activity	GO:0003712	IDA:UniProtKB

GO - Biological Process
positive regulation of transcription, DNA-templated	GO:0045893	IBA:GO_Central
regulation of transcription by RNA polymerase II	GO:0006357	IDA:UniProtKB
regulation of transcription initiation from RNA polymerase II promoter	GO:0060260	ISS:FlyBase
response to heat	GO:0009408	IMUniProtKB
response to lipopolysaccharide	GO:0032496	IMUniProtKB









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31437
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.25|      23|      27|     706|     732|       1
---------------------------------------------------------------------------
  685-  707 (36.72/21.29)	LAQNPAE..PDEMLLDE..CSLLSKQL
  708-  734 (29.53/29.43)	LIPQPTKfnPTTLLSAQgfAAVKSGQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.64|      25|     207|      91|     115|       3
---------------------------------------------------------------------------
   91-  115 (46.95/27.96)	ISVLQWS..PNGEQLLLGY.....VGGRVEIW
  301-  332 (35.69/19.64)	ISHLKWTriANEDVIFIAYacpdgAGSQLEQW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.52|      14|      27|     768|     782|       4
---------------------------------------------------------------------------
  768-  782 (24.59/17.76)	LGARPSHIRRCaRCG
  798-  811 (31.93/18.92)	LKAWFSKWLHC.HCG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.15|      35|     459|     154|     207|       6
---------------------------------------------------------------------------
  159-  193 (64.40/72.32)	HTYYAE......KFERVEQQ...................RPTLSGF..GGVASEGCVLLTSS
  511-  572 (43.75/15.07)	HFYYANflalksNICRMQQQefdnliilhaisttfksllRPSDLGFqdKGPADNLAIKLAES
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31437 with Med16 domain of Kingdom Metazoa
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