<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31432

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMHLEHLMSSTTAVSWSKIGLIAYGDAQSQDGNLCITFLETVNGSNWRFHPPKKYVIHPQLHEDQSSNGNPKSPLFFHDLRSMHWNNWGLLNGELLAVCDELGNMTVLAAGQGLNGNGAYDRLSVLFQDNIFKIHNQVLPLESVPKKDATPKVERKHTKKEYYSTILDFQWIGNQKPSVAQVAAQRDRTNNIFKNQMHQCPPYGVFHPASIKSACIAIRRNGYIDLWYQFSNTLDFKKISLQLSKDKESEWLQYAQIAHTDKEQCFLIGVFSNVAKSFAFYELLINWNVNTTNQAMFHDPKLTLRHILRVRPDALGPNGELLKLENFHVISKTALPGTRPEILISYNILGTERSLVRRFQMVLSNPDMVFLSSLGLAITALHNNHSVLRYSMKHVQDLTFDSKIMDIQSHSLDALVCFRLHNGRFQLYNRHTWAVESETADAKQIGGYTKDTIISIFGSGFNYPLLPPADAIEWCAISPSSGGIILKLKCKPQPTFYALEQSVLTDPSRDIVHATAFAFEFVRFNNMIHSGEDLAIAAKTHVFRLQRLSEERAVNFIASVIGAILSLYGIHFDGPKEILEKLLQSKAIQKIFLLQMELGSHLKNKNVYSMAYASMKLRSINLAMNGVARNVHAMIQHTAVVNSLPNGRAFQFAFSKQDLIYSLIPSVNWFVSFVTFLTQQLIMLVNNPMDNTHSLVLGILSCITTRHLMLKVILELKNMIGLITKFPETTYTVLNESSRFLRKALGDSPVNLEKFEVFLNEINNKFLSLLDDHGAQSMDREPSFMVKAEIPPALGHVREFLLSFAGSALLAQTNLAEVFFASTHNLRIFDHQHFHPSVANLLQPPEKGLVVDDAILPDACRGSSSFSPLDYDDISSEWVDMSALVRIKRCVRCGCVTRAGNPVAKNNTILETSIVTKRWTALYSRYCQCTGLLYELDTP
Length938
PositionTail
OrganismAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Eremothecium.
Aromaticity0.10
Grand average of hydropathy-0.086
Instability index39.28
Isoelectric point8.43
Molecular weight105824.56
Publications
PubMed=15001715
PubMed=23749448

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). 
GO - Cellular Component
core mediator complex	GO:0070847	IEA:EnsemblFungi
mediator complex	GO:0016592	IEA:EnsemblFungi

GO - Biological Function
RNA polymerase II activating transcription factor binding	GO:0001102	IEA:EnsemblFungi

GO - Biological Process
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:EnsemblFungi
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:EnsemblFungi
regulation of establishment of protein localization to chromosome	GO:0070202	IEA:EnsemblFungi
RNA polymerase II preinitiation complex assembly	GO:0051123	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31432
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.76|      29|      37|     372|     406|       1
---------------------------------------------------------------------------
  372-  402 (42.53/43.16)	SL.GLAITALHNNHSVLrYSmKH...VQDLTFDSK
  410-  442 (43.23/22.78)	SLdALVCFRLHNGRFQL.YN.RHtwaVESETADAK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     221.87|      75|     625|     129|     284|       2
---------------------------------------------------------------------------
  191-  284 (106.80/201.69)	IFKNQmHqcppygvFHPaSI........KSACI..AIRRNGYIDlWYQFSnTLDFKKISlqlskdkeSEWLQYAQIAHTDK.EQCFLIGVFSN.VAKSFAFYELLI
  827-  913 (115.07/54.69)	IFDHQ.H.......FHP.SVanllqppeKGLVVddAILPDACRG.SSSFS.PLDYDDIS........SEWVDMSALVRIKRcVRCGCVTRAGNpVAKNNTILETSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.68|      20|      40|      27|      46|       3
---------------------------------------------------------------------------
   27-   46 (38.47/25.69)	QSQDGN....LCITFLETVNGSNW
   64-   87 (36.21/23.72)	QSSNGNpkspLFFHDLRSMHWNNW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.47|      22|      35|     299|     322|       5
---------------------------------------------------------------------------
  299-  322 (29.64/25.51)	PKlTLRHILrVRPDALGPNGELLK
  335-  356 (37.83/22.41)	PG.TRPEIL.ISYNILGTERSLVR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31432 with Med16 domain of Kingdom Fungi
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