<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31431

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMNQQNPEEEVSLVNNSGGGGIIEAPAIVEEKEEEGLQQKQEETIESTDPILVVVEEKLLEKSVDGEKEDDNSSSSNMEIDPVSPATVFCVKLKQPNSNLLHKMSVPELCRNFSAVAWCGKLNAIACASETCARIPSSKANTPFWIPIHILIPERPTECAVFNVVADSPRDSVQFIEWSPTSCPRALLIANFHGRITIWTQPTQGSANLVHDATSWQCEHEWRQDIAVVTKWLTGASPYRWLSSKPSSGTNAKSTFEEKFLSQSSESSARWPNFLCVCSVFSSGSVQIHWSQWPSNQGSTAPKWFSTKKGLLGAGPSGIMAADAIITDSGAMHVAGVPIVNPSTIVVWEVTPGPGNGLQATPKISTGSRVPPSLSSSSWTGFAPLAAYLFSWQEYLISEIKQGKKPSDQDSSDAISLSCSPVSNFSAYVSPEAAAQSAATTTWGSGVTAVAFDPTRGGSVIAVVIVEGQYMSPYDPDEGPSITGWRVQRWESSVQPVVLHQIFGNPTSNFGGQVPTQTVWVSRVDMSIPPTKDFKNHQVAAAGPSVDAPKEPDSGDEKANKVVFDPFDLPSDIRTLARIVYSAHGGEIAIAFLRGGVHIFSGPTFSPVENYQINVGSAIAAPAFSPTSCCSASVWHDAAKDCAMLKIIRVLPPALPRNQSKVDQSTWERAIAERFWWSLLVGVDWWDAVGCTQSAAEDGIVSLNSVIAVMDADFHSLPSTQHRQQYGPNLDRIKCRLLEGTNAQEVRAMVLDMQARLLLDMLGKGIESALVNPSALVFEPWRVDGETITGINPEAMAVDPALVSSIQAYVDAVLDLASHFITRLRRYASFCRTLASHAASAGTGSNRNNVTSPTQNASSPATPQVFPDKSLYLAVGQPTTTTTTTATTNSSGSSHVQAWMQGAIAKISSSNDGSNSTASPISGSPTFMPISINTGTFPGTPAVRLIGDCHFLHRLCQLLLFCFLQRSSRFPQRNADVSSQKLQTGATSKLEEVNSAKPTPALNRIEDAQGFRGAQLGTGVKGIDENSARTTKMGSGNAGQGYTYEEVRVLFHILMDLCKRTSGLAHPLPGSQVGSGNIQVRLHYIDGNYTVLPEVVEAALGPHMQNMPRPRGADAAGLLLRELELHPPSEEWHRRNLFGGPGSEPEDMILTDDVSKLSNSLDLPDTNFSGICDGYNRVHSLWPRKRRMSERDAAFGSNTSVGLGAYLGIMGSRRDVVTATWKTGLEGVWYKCIRCLRQTSAFASPGATKQPNPNERETWWTSRWVYCCPMCGGTWVRVV
Length1278
PositionTail
OrganismArabidopsis thaliana (Mouse-ear cress)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Brassicales> Brassicaceae> Camelineae> Arabidopsis.
Aromaticity0.08
Grand average of hydropathy-0.225
Instability index46.19
Isoelectric point5.82
Molecular weight138185.05
Publications
PubMed=19067974
PubMed=10617198
PubMed=27862469
PubMed=12753580
PubMed=17560376
PubMed=18614706
PubMed=22021418
PubMed=22494141

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Involved in the regulation of the circadian clock, in the control of flowering time, in freezing- and osmotic- stress tolerance and in both salicylic acid- and jasmonate-mediated defense gene expression. 
ECO:0000269	PubMed:12753580
ECO:0000269	PubMed:18614706
ECO:0000269	PubMed:19067974
ECO:0000269	PubMed:22494141
GO - Cellular Component
mediator complex	GO:0016592	IDA:UniProtKB
nucleus	GO:0005634	IDA:TAIR
GO - Biological Function
GO - Biological Process
circadian regulation of gene expression	GO:0032922	IMTAIR
positive regulation of plant-type cell wall cellulose biosynthetic process	GO:2001011	IMTAIR
positive regulation of systemic acquired resistance	GO:1901672	IMTAIR
regulation of cell wall pectin metabolic process	GO:1902066	IGI:TAIR
regulation of ethylene-activated signaling pathway	GO:0010104	IMTAIR
regulation of jasmonic acid mediated signaling pathway	GO:2000022	IMTAIR
regulation of long-day photoperiodism, flowering	GO:0048586	IMTAIR
regulation of plant-type cell wall cellulose biosynthetic process	GO:2001009	IGI:TAIR
regulation of transcription, DNA-templated	GO:0006355	IMTAIR
response to osmotic stress	GO:0006970	IMTAIR
root development	GO:0048364	IGI:TAIR
trichome branching	GO:0010091	IMTAIR
trichome papilla formation	GO:1905499	IMTAIR









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31431
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     745.90|     285|     444|     130|     439|       1
---------------------------------------------------------------------------
  130-  288 (183.58/136.25)	............................................................................................................................................................................................................................................................................TCARIPSS...KAN....TPFWIP..........................IHILIPERPTECAV..FNVVADSPRDSVQFIEwSPTSCPRALLIANFHGRITIWTQPTQ..GSANLVHDATSwqcehewrQDIAV..VTKWLTGASPYRwlSSKPSSGTNAKStFEEKFLSQSSESSARWPNFLCVCSVFSSGSVQIH
  289-  439 (149.94/119.92)	WSQWPSNQ..GSTAPKWFSTKKGLLgAGpSGIMAADAIITDSGA.....MHVAGV..PIVNPSTIVV..WEVTPGPGNGLqaTPKistGSRVPPSLSSSSWtgfAPLAAYLfSWQEYLISEIKQGKKPSDQDSSDAISLSCSpvSNFSAYVSPEAAAQSAAT................................................................................................................................................................................................................................................................................................................
  546-  703 (125.35/66.75)	..................................................................................................................................................................ttwgsgvtavafdptrggsviavvivegqymspydpdegpsitgwrvqrwessvqpvvlhqifgnptsnfggqvptqtvwvsrvdmsipptkdfknhqvaaagpsvDAPKEPDSgdeKANkvvfDPFDLPsdirtlarivysahggeiaiaflrggVHIF..SGPTFSPVenYQINVGSAIAAPAF...SPTSCCSA..........SVW.............HDAA.........KDCAMlkIIRVLPPALPRN..QSKVDQSTWERA.IAERFWWSLLVGVDWWDAVGCTQSAAEDGIVSLN
  713-  987 (287.03/169.49)	FHSLPSTQhrQQYGPNLDRIKCRLL.EG.TNAQEVRAMVLDMQArllldMLGKGIesALVNPSALVFepWRVDGETITGI..NPE...AMAVDPALVSSIQ...AYVDAVL.DLASHFITRLRRYASFCRTLASHAASAGTG..SNRNNVTSPTQNASSPAT........................................................pqvfpdkslylavgqptttttttattnssgsshvqawmqgaiakisssndGSNSTASP...ISG....SPTFMP..........................ISINTGTFPGTPAV...RLIGD.....CHFLH...RLC..QLLLFCFLQRSSRFPQRNAdvSSQKLQTGATS............................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     134.97|      39|     776|     441|     489|       2
---------------------------------------------------------------------------
  441-  480 (65.20/34.59)	TWGSGVTAVAFDPTRGGSVIAVVIVEGQYMSPyDPDEGPS
 1219- 1257 (69.77/33.00)	TWKTGLEGVWYKCIRCLRQTSAFASPGATKQP.NPNERET
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.27|      33|     632|     499|     533|       3
---------------------------------------------------------------------------
  499-  533 (57.12/40.89)	HQ..IFGNPTSNFGGQVPTQTvwVSRVDMSIP.PTKDF
 1132- 1167 (50.15/28.51)	HRrnLFGGPGSEPEDMILTDD..VSKLSNSLDlPDTNF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31431 with Med16 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




NANANA









Molecular Recognition Features






MoRF SequenceStartStop




1) EAPAIVEEKEEE
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