<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31431

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMNQQNPEEEVSLVNNSGGGGIIEAPAIVEEKEEEGLQQKQEETIESTDPILVVVEEKLLEKSVDGEKEDDNSSSSNMEIDPVSPATVFCVKLKQPNSNLLHKMSVPELCRNFSAVAWCGKLNAIACASETCARIPSSKANTPFWIPIHILIPERPTECAVFNVVADSPRDSVQFIEWSPTSCPRALLIANFHGRITIWTQPTQGSANLVHDATSWQCEHEWRQDIAVVTKWLTGASPYRWLSSKPSSGTNAKSTFEEKFLSQSSESSARWPNFLCVCSVFSSGSVQIHWSQWPSNQGSTAPKWFSTKKGLLGAGPSGIMAADAIITDSGAMHVAGVPIVNPSTIVVWEVTPGPGNGLQATPKISTGSRVPPSLSSSSWTGFAPLAAYLFSWQEYLISEIKQGKKPSDQDSSDAISLSCSPVSNFSAYVSPEAAAQSAATTTWGSGVTAVAFDPTRGGSVIAVVIVEGQYMSPYDPDEGPSITGWRVQRWESSVQPVVLHQIFGNPTSNFGGQVPTQTVWVSRVDMSIPPTKDFKNHQVAAAGPSVDAPKEPDSGDEKANKVVFDPFDLPSDIRTLARIVYSAHGGEIAIAFLRGGVHIFSGPTFSPVENYQINVGSAIAAPAFSPTSCCSASVWHDAAKDCAMLKIIRVLPPALPRNQSKVDQSTWERAIAERFWWSLLVGVDWWDAVGCTQSAAEDGIVSLNSVIAVMDADFHSLPSTQHRQQYGPNLDRIKCRLLEGTNAQEVRAMVLDMQARLLLDMLGKGIESALVNPSALVFEPWRVDGETITGINPEAMAVDPALVSSIQAYVDAVLDLASHFITRLRRYASFCRTLASHAASAGTGSNRNNVTSPTQNASSPATPQVFPDKSLYLAVGQPTTTTTTTATTNSSGSSHVQAWMQGAIAKISSSNDGSNSTASPISGSPTFMPISINTGTFPGTPAVRLIGDCHFLHRLCQLLLFCFLQRSSRFPQRNADVSSQKLQTGATSKLEEVNSAKPTPALNRIEDAQGFRGAQLGTGVKGIDENSARTTKMGSGNAGQGYTYEEVRVLFHILMDLCKRTSGLAHPLPGSQVGSGNIQVRLHYIDGNYTVLPEVVEAALGPHMQNMPRPRGADAAGLLLRELELHPPSEEWHRRNLFGGPGSEPEDMILTDDVSKLSNSLDLPDTNFSGICDGYNRVHSLWPRKRRMSERDAAFGSNTSVGLGAYLGIMGSRRDVVTATWKTGLEGVWYKCIRCLRQTSAFASPGATKQPNPNERETWWTSRWVYCCPMCGGTWVRVV
Length1278
PositionTail
OrganismArabidopsis thaliana (Mouse-ear cress)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Brassicales> Brassicaceae> Camelineae> Arabidopsis.
Aromaticity0.08
Grand average of hydropathy-0.225
Instability index46.19
Isoelectric point5.82
Molecular weight138185.05
Publications
PubMed=19067974
PubMed=10617198
PubMed=27862469
PubMed=12753580
PubMed=17560376
PubMed=18614706
PubMed=22021418
PubMed=22494141

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Involved in the regulation of the circadian clock, in the control of flowering time, in freezing- and osmotic- stress tolerance and in both salicylic acid- and jasmonate-mediated defense gene expression. 
GO - Cellular Component
mediator complex	GO:0016592	IDA:UniProtKB
nucleus	GO:0005634	IDA:TAIR

GO - Biological Function
GO - Biological Process
circadian regulation of gene expression	GO:0032922	IMTAIR
positive regulation of plant-type cell wall cellulose biosynthetic process	GO:2001011	IMTAIR
positive regulation of systemic acquired resistance	GO:1901672	IMTAIR
regulation of cell wall pectin metabolic process	GO:1902066	IGI:TAIR
regulation of ethylene-activated signaling pathway	GO:0010104	IMTAIR
regulation of jasmonic acid mediated signaling pathway	GO:2000022	IMTAIR
regulation of long-day photoperiodism, flowering	GO:0048586	IMTAIR
regulation of plant-type cell wall cellulose biosynthetic process	GO:2001009	IGI:TAIR
regulation of transcription, DNA-templated	GO:0006355	IMTAIR
response to osmotic stress	GO:0006970	IMTAIR
root development	GO:0048364	IGI:TAIR
trichome branching	GO:0010091	IMTAIR
trichome papilla formation	GO:1905499	IMTAIR









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31431
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     745.90|     285|     444|     130|     439|       1
---------------------------------------------------------------------------
  130-  288 (183.58/136.25)	............................................................................................................................................................................................................................................................................TCARIPSS...KAN....TPFWIP..........................IHILIPERPTECAV..FNVVADSPRDSVQFIEwSPTSCPRALLIANFHGRITIWTQPTQ..GSANLVHDATSwqcehewrQDIAV..VTKWLTGASPYRwlSSKPSSGTNAKStFEEKFLSQSSESSARWPNFLCVCSVFSSGSVQIH
  289-  439 (149.94/119.92)	WSQWPSNQ..GSTAPKWFSTKKGLLgAGpSGIMAADAIITDSGA.....MHVAGV..PIVNPSTIVV..WEVTPGPGNGLqaTPKistGSRVPPSLSSSSWtgfAPLAAYLfSWQEYLISEIKQGKKPSDQDSSDAISLSCSpvSNFSAYVSPEAAAQSAAT................................................................................................................................................................................................................................................................................................................
  546-  703 (125.35/66.75)	..................................................................................................................................................................ttwgsgvtavafdptrggsviavvivegqymspydpdegpsitgwrvqrwessvqpvvlhqifgnptsnfggqvptqtvwvsrvdmsipptkdfknhqvaaagpsvDAPKEPDSgdeKANkvvfDPFDLPsdirtlarivysahggeiaiaflrggVHIF..SGPTFSPVenYQINVGSAIAAPAF...SPTSCCSA..........SVW.............HDAA.........KDCAMlkIIRVLPPALPRN..QSKVDQSTWERA.IAERFWWSLLVGVDWWDAVGCTQSAAEDGIVSLN
  713-  987 (287.03/169.49)	FHSLPSTQhrQQYGPNLDRIKCRLL.EG.TNAQEVRAMVLDMQArllldMLGKGIesALVNPSALVFepWRVDGETITGI..NPE...AMAVDPALVSSIQ...AYVDAVL.DLASHFITRLRRYASFCRTLASHAASAGTG..SNRNNVTSPTQNASSPAT........................................................pqvfpdkslylavgqptttttttattnssgsshvqawmqgaiakisssndGSNSTASP...ISG....SPTFMP..........................ISINTGTFPGTPAV...RLIGD.....CHFLH...RLC..QLLLFCFLQRSSRFPQRNAdvSSQKLQTGATS............................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     134.97|      39|     776|     441|     489|       2
---------------------------------------------------------------------------
  441-  480 (65.20/34.59)	TWGSGVTAVAFDPTRGGSVIAVVIVEGQYMSPyDPDEGPS
 1219- 1257 (69.77/33.00)	TWKTGLEGVWYKCIRCLRQTSAFASPGATKQP.NPNERET
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.27|      33|     632|     499|     533|       3
---------------------------------------------------------------------------
  499-  533 (57.12/40.89)	HQ..IFGNPTSNFGGQVPTQTvwVSRVDMSIP.PTKDF
 1132- 1167 (50.15/28.51)	HRrnLFGGPGSEPEDMILTDD..VSKLSNSLDlPDTNF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31431 with Med16 domain of Kingdom Viridiplantae
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