<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31430

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMDLLYTTVRKGNANTFSFTETQHNFEFLCNTSSCNVLAFTTTNELTEPSPIQGWGFHIYVVDLNAPWFPYRVTSNKYPISVLQWDVLGRYLLVGDRNGHVQIFVQKDNLLSEWKSVYSVKFPGENIIAAAFFHNGRKLNLQTDKKDQYLYLEKFQKVKFAASVRQFGGVPVEGVLIVSATGMLGAFVIPPESNANIQKLSEPIKLVPVTESLAVTRNYYTTADICYGKNGYFRVAVGNGDSKSANSNMIQCFRVAVKQREETLEINSTALPSFFLAEGMGKDLKELRVAHVQWVFSEDADSLIVASNHTGGGCFVEQWELTEESTPIHKLFQSNKNEPFKTLLWVSKSQYMYTSKVIKICTTKLNFLSSSFVYLAMSDNSIHCLQRDTLKRLTCTNIVSIRDPNDHSSKQIKLGLKIGAIDVTHLGHLFVTLDTFGQLYVYRCNFMCQDQLGTPALIVQTVNLLEYCLVTGLDSLDILLTLKTQILENVLERLTENFHRQPPNVQQYYYVNFLTMKIALYRLSISGQQKAHDLSNLLILHSILIAFKSLLRPSDLTSHDKGPAENLAMVLSESVPDVDKVLLNVEAKEFTMERPTLQSLQQLIQWVADLALNILAKLPESRSFMSNKSQGYDISKDIIALNSIRELLVMIRIWGLLNPQCLPVFSRSADNLDILGTLFRLLTKLSLNPNEPDDLLLDECCLLPNQVLIPQLQYVPSRTMIASPLLPHVTLPVMCDYGVENESLKFCPEVPIVEGGLSNDNVIDSVMYLQLGRRPPSLRRCTRCGSCSSVVSVAKTAAMKAWEQRWIDKCRCNGFWRLEVA
Length820
PositionTail
OrganismAedes aegypti (Yellowfever mosquito) (Culex aegypti)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Culicinae> Aedini> Aedes> Stegomyia.
Aromaticity0.09
Grand average of hydropathy-0.028
Instability index40.37
Isoelectric point6.95
Molecular weight92493.73
Publications
PubMed=17510324

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31430
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.42|      13|      20|     726|     741|       2
---------------------------------------------------------------------------
  726-  741 (16.58/21.96)	PHVtlPVMcDYGVENE
  747-  759 (23.84/14.38)	PEV..PIV.EGGLSND
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.97|      16|      21|     608|     624|       3
---------------------------------------------------------------------------
  608-  624 (22.06/19.82)	DLALNILAkLPESRSFM
  632-  647 (24.91/16.80)	DISKDIIA.LNSIRELL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31430 with Med16 domain of Kingdom Metazoa
Unable to open file!