<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31424

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMTEDWQSQKFRQNVISKIHDLLPPNAQDQTKNAGVMENHIFRKSRTKDEYLGLVAKLFMHYKDMSRKSQQQQQQQQQQGGPPPNAEMGGGQNMMQDPLNALQNLASQGNRNPQMMPMGAGGGAPVPGGPGTASNLLQSLNQQRPGQQQMQPMSNIRGQMPMGAGGAGAQQMMQVQQMQQGGNAPGVMNVMGAGGGQNQGQIVGNPGQQMGVGVGMPNQMVGPGPNSGPAVGGAGGPNAAPGAGGPGPNQMQGGPMNVNAMQQMPPMQQIQQNQLGMGMNPMMRMGQGNGMGGPQGMPGQGMQGMPQGPHNVVGGPAGQQQVGGAGLPPNAVQQGGMNPMGGMGVNMPPNLQQKPNMPMGQAGQMFPGNRGGVGVGGQQPGQPFMRSSPSPADAQQLQQQAQLQQMQQQQQQLVVGNQTPTQQPPTPQMPTPNMIPSPALVPQSSPQMMQMQNSQRNIRQQSPSASINTPGQVTGNSPFNPQEEALYREKYKQLTKYIEPLKRMLAKISNDGTNVEKMTKMSKLLEILCNPTQRVPLETLLKCEKALEKMDLISYSGQQFGKSSNPLLEVINTTLQSPVANHTLYRTFRPTLELLFGTDITAPVPAKRPRVEEKSTSFEQEVPHVLQGEIARLDTKFKVKLDTTSQINNKAIRLICCLDDKRLPSVPPVSVSVPEEYPWQAPDCSLAEQEYSATPFLQTVQQALIARISKLPKNYSLSHLLDTWEMAVRQACSPQSKPRAVCELSTLLGV
Length749
PositionTail
OrganismDrosophila melanogaster (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.03
Grand average of hydropathy-0.645
Instability index62.02
Isoelectric point9.38
Molecular weight80525.19
Publications
PubMed=10731132
PubMed=12537572
PubMed=12537569
PubMed=16751183

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for activated transcription of the MtnA, MtnB and MtnD genes. 
ECO:0000250	
ECO:0000269	PubMed:16751183
GO - Cellular Component
mediator complex	GO:0016592	ISS:UniProtKB
nucleus	GO:0005634	ISS:FlyBase
GO - Biological Function
transcription coregulator activity	GO:0003712	ISS:UniProtKB
GO - Biological Process
ovarian follicle cell development	GO:0030707	IMFlyBase
regulation of transcription by RNA polymerase II	GO:0006357	ISS:UniProtKB

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP31424
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     456.02|      49|      49|     243|     291|       1
---------------------------------------------------------------------------
   79-  126 (63.93/14.06)	GGPP..PNA..EMGGGQNM....MQD..PLNALQ.NLASQGnR.NP.qMMPMGAGGGapVP
  127-  163 (45.25/ 7.53)	GGPGtaSNL..LQSLNQQRPG..QQQMQPMSNIR......G.......QMPMGA.......
  164-  197 (53.70/10.48)	GGAG..AQQ..M....MQV...........QQMQQ...G.G.N.APgvMNVMGAGGG..QN
  203-  229 (42.11/ 6.43)	GNPG....................QQMG.........VGVG.MpNQ..MVGPGPNSG..PA
  243-  290 (101.37/27.15)	GGPG..PNQ..MQGGPMNVNA..MQQMPPMQQIQQNQLGMG.M.NP..MMRMGQGNG..M.
  340-  373 (50.64/ 9.42)	.............GG.MGVN......MPPNLQ.QKPNMPMG.Q.AG..QMFPGNRGG..VG
  375-  414 (43.44/ 6.90)	GGQQ..PGQpfMRSSPSPADAqqLQQQAQLQQMQQQQ................Q.QL..VV
  415-  456 (55.59/11.14)	GNQT..PTQ..QPPTP.........QMPTPNMIPSPALVPQ.S.SP.qMMQM.QNSQ..RN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.24|      26|      29|     489|     517|       2
---------------------------------------------------------------------------
  489-  516 (39.80/33.74)	KYKQLTKYIEPLKRM.LakISNDGTNVEK
  535-  561 (40.45/22.45)	PLETLLKCEKALEKMdL..ISYSGQQFGK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.58|      15|      19|     291|     308|       3
---------------------------------------------------------------------------
  291-  305 (33.77/ 8.15)	GGPQGMPGQGMQGMP
  313-  327 (28.80/ 8.92)	GGPAGQQQVGGAGLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     114.09|      40|      75|     617|     660|       6
---------------------------------------------------------------------------
  617-  660 (61.64/56.11)	FEQE...VPH...VLQGEIAR...LDTKFKVK..LDTTsQInnkAIRLICCLDDK
  686-  736 (52.45/35.15)	AEQEysaTPFlqtVQQALIARiskLPKNYSLShlLDTW.EM...AVRQACSPQSK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31424 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) QNVISKIHDLLPPNAQDQTKNAGVMENHIFR
2) YKDMSRKSQQQQQQQQQQGGPPPNAEMGGGQNMMQDPLNALQNLASQGNRNPQMMPMGAGGGAPVPGGPGTASNLLQSLNQQRPGQQQMQPMSNIRGQMPMGAGGAGAQQMMQVQQMQQGGNAPGVMNVMGAGGGQNQGQIVGNPGQQMGVGVGMPNQMVGPGPNSGPAVGGAGGPNAAPGAGGPGPNQMQGGPMNVNAMQQMPPMQQIQQNQLGMGMNPMMRMGQGNGMGGPQGMPGQGMQGMPQGPHNVVGGPAGQQQVGGAGLPPNAVQQGGMNPMGGMGVNMPPNLQQKPNMPMGQAGQMFPGNRGGVGVGGQQPGQPFMRSSPSPADAQQLQQQAQLQQMQQQQQQLVVGNQTPTQQPPTPQMPTPNMIPSPALVPQSSPQMMQMQNSQRNIRQQSPSASINTPGQVTGNSPFNPQEEAL
12
61
42
485










Molecular Recognition Features






MoRF SequenceStartStop




NANANA