<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31423

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMDVPGPDSDWRSPAFRQKVVAQIEEAMRKAGTGHTKSSTEMESHVFTKAKTREEYLSMVARLIIHFRDIHKKAQGGPDPINALQNLPGGVPGVIGPRPPGAQMGGMGQMSMGPHAMQGVAGGQQGAGAAGPMQQMIQQQQQQQQQQQQQQSIQFQTFQPQQQQQATMQSQQPSAMFQQIRLQQLQQHHQNQQMQHQNQQQQQAQNQQQQNQLHQTRMQQQLQLQQLQQQQQQQLHQQQVHAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQSIQQMQQQQQLQVQAQGQPQVQGQGGAVQMPPHSQQQQVLVPQMVQGQHSQMSALSQQQQLKLQQAMQARMQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQVQQVQQASQLTAVPGQMMPRPGMQIPPRLPRATPNSAIPQNPVAIGGQQMPQAQQMMSSPSPVQVQTPQSMPPPPQPQPSPQPPSSQPNSVSSGPTPSPGGFQPSPSPQPSQSPASSRTPQSYPLQVPSPGPLNTPGNPSSVMSPAGASQSEDQLYMDKLRQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLNILTDPNTRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPCTKKQYLCQPILDAVLANIRSPVFNHSLYRTFAPAMTAIHGPQITGPSIPSRKRKLEDDERQAIPNILQGEVARLNSKFLVNLDPSFCSNNGMVHLICKLDDKNLPSVPPLQLSIPADYPDQSPHWEDDGQQYEANPFLRTVHKNMTSKLLQLPDKHSVTALLNTWAQSVRQACLSA
Length809
PositionTail
OrganismDanio rerio (Zebrafish) (Brachydanio rerio)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Ostariophysi> Cypriniformes> Danionidae> Danioninae> Danio.
Aromaticity0.03
Grand average of hydropathy-0.955
Instability index82.83
Isoelectric point9.62
Molecular weight89862.06
Publications
PubMed=17208216

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol- dependent gene regulation (By similarity). Positively regulates the Nodal signaling pathway. 
GO - Cellular Component
cytoplasm	GO:0005737	IEA:UniProtKB-SubCell
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31423
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     188.87|      39|      39|     148|     186|       3
---------------------------------------------------------------------------
  148-  186 (75.05/14.98)	QQQSIQFQTFQPQQQQQATMQSQQ....PSAMFQQIRLQQLQQ
  189-  228 (60.41/10.03)	QNQQMQHQN...QQQQQAQNQQQQnqlhQTRMQQQLQLQQLQQ
  324-  356 (53.41/ 7.66)	QQQVLVPQMVQGQHSQMSAL.SQQ.........QQLKLQQAMQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     162.69|      29|      30|     486|     514|       8
---------------------------------------------------------------------------
  406-  430 (30.97/ 6.23)	......SQLTAVPGQMMPRPGMQ..iPPRLPRA
  432-  462 (37.66/ 9.24)	PNSaIPQNPV.AIGG.QQMPQAQqmmSSPSPVQ
  486-  514 (58.93/18.79)	PNS.VSSGPTPSPGGFQPSPSPQ...PSQSPAS
  517-  536 (35.13/ 8.10)	T.......PQSYP..LQ.VPSPG...PLNTPGN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     103.93|      20|      28|      87|     106|      10
---------------------------------------------------------------------------
   87-  106 (36.52/14.37)	PGGVPGVIGPRPPGAQMGGM
  113-  132 (35.98/13.99)	PHAMQGVAGGQQGAGAAGPM
  287-  306 (31.42/10.74)	AQSIQQMQQQQQLQVQAQGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.34|      19|      28|     585|     603|      11
---------------------------------------------------------------------------
  585-  603 (33.98/19.64)	LSKMKSLLNILTDPNTRCP
  614-  632 (36.36/21.61)	LEKLKNDMAVPTPPPPPVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.27|      18|     121|     636|     653|      13
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  636-  653 (31.93/23.79)	KQYLCQPILDAVLANIRS
  763-  780 (33.34/25.22)	QQYEANPFLRTVHKNMTS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31423 with Med15 domain of Kingdom Metazoa
Unable to open file!