<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31419

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMELDWRSTLSNQERSKYITELAQILADISQINGGARANFDLEKLKKTAEQFETSLYASSSSKELYLDAMRKRIAAMDAAKKKTLANQKQKAAAQRKGFGLAPTLNPQMFLNQQAQARQQARPMRGSVGGGQSPVMMMPQHGVPAHVAHGVPPGVAVSQAKRAQLSLQQQQQINEMKVAEIPRELLQRIPNIPPGVTTWQQVTELAQQKRLTQSDLQIAKQVYQMHQQMMVKSKMQQASLNQLTPQQRAQLQQRQQSTQQSQSAPPQAPQVAQSQQVPAQKPQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHAAAQAQLQHPNAYQQKNMMAQQSAAALQQGQQQPRQMGPQQAREVPNVLNKLNQVFSPAEQKALYENGKKLVQDLQLAGKLPASLTQQQQILYIKKYINQMVLKKLQQNIRLAQQIGAANSANTQSQMAAQAGARFTPGMAQHSQFAQQQHTGNQAQVQSQVSQSISQQQAQLTQKVQQAQQSQLQQTQEQDPQHTQLADSFSQRQFTSPTLAKPSANVSTIAQQQTQPTALSQSHPQQQQGSQAQQQLLQQQQGSQAQQQLLQQQQQQPPPPPPQPQQQTQQPQQPQQQQQPQPQPQLQQQQQLGLQPHQPQLAQAQAQQPQPQQQTQQQTQQQQQQQQQQQQQQTQQQTQHQPQPQLKPQSQQPQPVPQQVQSQQPQQVQSQQQPQPQQLSQPAQQQSQQQQQQQQQSQQQKLRQVQLPQQTPKITLPRPTEQDMMILKRINSEVAKSPLRLSNITNQLTPEQKQMIKNKLQANQQLLSNVDNFIPTLYLITRNEENVRQLLQIRMLAKEIMEHASKGVFIVPPDVVDKVIFRYQKYYEFIKEQLLRRHQQLFSTRQQQMQQQVVQQQQAGQIKLGQNAVGAPQNPQVTTNTDIAMQQQRVQGSFQQMQQQIRQQQVKQAQLQQAQQQAQQQQQAQQLQQGHMPVQQSMPLAGVQTVMATQAATLPQHASPVSSNTANIPKTGDAPVSIDSVTPVPPGIVNSSGPSPVAGKQILAATMVPQHKLSPTKSDFAQAPTADNPYQVDELRLKNLAIRKAEIMSRFKHRQEIFEHSPVDLFLCTLADCMGIKDGSYELLAPIPALMVEQINGTGKKKFTKAQQRVREQDSIECYVKDNKLMMSSKFSADERSYSIHDRDISSCFLDLYGLSDCTSLSFDSSSAEPPTEQVNKKRSHDSLEISPAESDSSLLNDSKKLKVDSPDDLFMTSNMMLDNKNAQPPIGLGLGVGLGEAGSSIWNWNYWESL
Length1320
PositionTail
OrganismAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Eremothecium.
Aromaticity0.04
Grand average of hydropathy-1.044
Instability index82.51
Isoelectric point9.68
Molecular weight149417.43
Publications
PubMed=15001715
PubMed=23749448

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31419
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.13|      15|      16|     282|     297|       1
---------------------------------------------------------------------------
  312-  327 (32.36/ 7.43)	QQQQQQQQQQQQQQqQ
  328-  342 (36.76/ 6.36)	QQQQQQQQQQQQQQ.Q
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     331.83|      42|      42|     667|     708|       2
---------------------------------------------------------------------------
  245-  287 (63.64/ 7.33)	QQRAQLQQRQQSTQQsQSA...PPQAPQvAQSQQ.VPAQKPQQQQQQ
  586-  626 (67.79/ 8.49)	TALSQSHPQQQQGSQ...A...QQQLQQ.QQGSQAQQQLLQQQQQQP
  627-  660 (66.36/ 8.09)	PPPPPQPQQQTQQPQ.QPQ...Q...Q...Q..QPQPQPQLQQQ.QQ
  691-  726 (63.73/ 7.35)	QQQQQQQQQQQQTQQ.QTQhqpQPQL.K.PQSQQPQP........VP
  727-  762 (70.33/ 9.20)	QQVQSQQPQQVQSQQ.QPQ...PQQLS......QP.AQQQSQQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     313.75|      53|      53|     476|     528|       4
---------------------------------------------------------------------------
  111-  164 (57.93/ 8.83)	..NQQAQARQQAR................PmrgsvGGG....QSPV....MMMPQH...GVP.AHVA......HGVPPGVAVSQakrAQ.....L
  477-  533 (78.35/15.14)	SANTQSQMAAQAGA.RF...........TP.....GMA....QHSQ....FAQQQH..TGNQ.AQVQ......SQVSQSISQQQ...AQ.ltqkV
  534-  584 (60.32/ 9.56)	QQAQQSQL.QQTQE.Q............DP............QHTQladsFSQRQF..TSPTlAKPS......ANVS.TIAQQQ...TQ......
  764-  829 (54.41/ 7.74)	QQSQQQKLRQVQLP.QQ...........TP.....KITlprpTEQD....MMILKR..INS...EVAksplrlSNITNQLTPEQ...KQmiknkL
  915-  980 (62.74/10.31)	QQQMQQQVVQQQQAgQIklgqnavgapqNP.....QVT....TNTD....IAMQQQrvQGSF.QQMQ..........QQIRQQQvkqAQ.....L
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.15|      33|      53|    1011|    1048|       5
---------------------------------------------------------------------------
 1011- 1048 (43.50/14.99)	GVQTVmatqAATL.PQHA.SPVSSNTANIPkTGDAPVSID
 1068- 1102 (44.66/ 8.17)	GKQIL....AATMvPQHKlSPTKSDFAQAP.TADNPYQVD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31419 with Med15 domain of Kingdom Fungi
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