<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31414

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPSSPYGANASTSHQHVKQNAHPSAPLSRTSPSLPPKPTVAMNGNGHYHAAPTSVALDKNKQTATSSHNLMIGVPPAATPNLSLAQSRPPDSKQSSDADGHPVFLSSAKGKQKQVDPIHIPLAQLEQELPLEEADLISLAALVERLANFGYEALQNLAETLPSLPSSSKRAKIFNTALNVRKQFIKLLVLARWSKDISDLQKSRNIIALLSEQQWQHEDVFAGLTDIRKILPNARMRNADLPTAIDVLHTGTYRRLPASIKQMAVAPKPFTDQQALLIVSRLEDALRTRMACRELVPAPLSNYTIHDGKVHFHVPGLFQAQLTASGSAQHELTPSSSDDRWWLLDLTFDVIASGSCAASCNRAFPRKPKRAYRERLRVWGDQQLSPVIQSDGVDESNARPLDIAADKTEQGTDVQIAPEKPTDAPTVNEANPAITATHHDDSLMPTAPVQRDAPLSRLFAFLQERALHYQMDILQHQAYELCRLNWGSNLRIETAERPRNLTVHYWTQAQGAAGATQRVESAAAGGSVQITIVDLPDTPGATETLAALFDGDDDQSSTTHDTASLTTVKRRGLQVTWDADRSILADAQSNNLAISPHSLDIEALLSSVIKQHTLALLRNLQRRILVSDHALSRLLRPEDCTLCLEHIQRQGDEFSTATETTTFNFLQIDLHASQRPRTAKSKPNPKPEQRSASCLAPLRLSVDPVTGRLLLDSEPAQSTTDLSSEQTSQQAASFTASILTTRPNYARLAEASDRINESIDALLDVLYRLDVFARVQEWERMASYLGLRSVRKLALRPQDLAKLGASTLASAEAAPQLFLPLRQSFGGYFLALQPSELAGVSIALVYVVQVMDPTGTPALSVQSIEWLDRAKIAAAASKVGSSGEDVGQEFVATEAGTKRKAPPGVQGETNDVDANFGSSELTIEELADVHSYCIALVSYFRVEQQLRMRGLPYLHVGSNTMRSSPPCKRQRRQQTADARDDGLFGEDASGGTASSDDEAFAGPAGVAGVAALVPSLCLRSIDVLGPSKSHLAKPNISLRVRHWDDDEKLCVEMRIKLRMKSRQFRTLHEVVALAASSDQQSTCALTWIDFDREASLLTLTTRDLDNCMSIFHTHWERVMRMVQLTREVLNASRAWQQRALRLRRSCKKPGERVELCRFELDSVVFSYGSIKVDGLEAKLLVRVRWQDAKLEMQAFSPIGVTQSGGYILEFGSMRSVQVEALDQDAQLREDGVSRWFDETHCLANPHKVMALELRRTVNVAARSAAMHAMLQPQAERIVWRGFLELLQHTLPLVREMAPLVDKCLTHAHVPEVEIKSATWFRFRFQDRYAIDVRLATRSRLVVSDASRALFASEVRTSESESESETTDAVPLDAVFGGSQLLNDLLDATTLARKCSKPKTRIAAQLSSAQFGPIPNIEHVLRSVHAKLDAITWIDARDHRSSAARLRVYELGRALLISLPSASHPNAQAAYHAIAHLVPLLIDRVEAQLARSTP
Length1493
PositionTail
OrganismUstilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Ustilaginomycotina> Ustilaginomycetes> Ustilaginales> Ustilaginaceae> Ustilago.
Aromaticity0.05
Grand average of hydropathy-0.288
Instability index51.93
Isoelectric point6.86
Molecular weight164479.54
Publications
PubMed=17080091

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). 
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31414
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     313.16|      88|      99|     849|     946|       1
---------------------------------------------------------------------------
  836-  924 (142.78/88.79)	ELAGV...SIALV.Y..V.............vQVMDPTGTPALSVQSIEWL.....DRAKIA...AAASKVGSSGEDVGQEFVATEAGTKRKAPPGVQGETND...VDANFGSSEL.TIE
  925- 1022 (99.39/82.12)	ELADVhsyCIALVsYfrVeqqlrmrglpylhvGSNTMRSSPPCKRQ...........RRQQT...ADARDDGLFGEDASGG.TASSDDEAFAGPAGVAG.......VAALVPSLCLrSID
 1310- 1383 (70.99/37.32)	........................................PEVEIKSATWFrfrfqDRYAIDvrlATRSRLVVS..DASRALFASEV...RTSESESESETTDavpLDAVFGGSQL.LND
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     147.24|      40|     100|      92|     135|       3
---------------------------------------------------------------------------
   11-   39 (39.25/15.89)	...............STSHQHVK.........QNAHPSAPLSRTSPSLPPKPT
   41-   89 (41.33/17.38)	AMNGNGHyhaaPTSVALDKNKQTatsshnlmiGVPPAATPNLSLAQSRP....
   95-  134 (66.66/44.62)	SSDADGH....PVFLSSAKGKQK.........QVDPIHIPLAQLEQELPLEEA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     153.62|      48|     129|    1090|    1140|       7
---------------------------------------------------------------------------
 1090- 1140 (74.36/62.54)	FDREASL.LTLTTRDLDNCMSIFHTHweRVMRMvQLTREVLNASRAWQQRAL
 1221- 1269 (79.26/53.79)	LDQDAQLrEDGVSRWFDETHCLANPH..KVMAL.ELRRTVNVAARSAAMHAM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     215.78|      54|     115|     389|     442|       8
---------------------------------------------------------------------------
  389-  442 (86.39/53.61)	QSDGV..DESNARPLDIAADKTEQGTDVQIAPEKPTDAPTVN.EANPAITATHHDDS
  445-  496 (56.94/32.53)	PTAPVqrDAPLSRLFAFLQERALH.YQMDILQHQAYELCRLNwGSNLRIETAE....
  508-  556 (72.46/43.64)	QAQGA..AGATQRVESAAA.....GGSVQITIVDLPDTPGAT.ETLAALFDGDDDQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.77|      24|     657|     144|     167|      10
---------------------------------------------------------------------------
  144-  167 (41.41/23.38)	ERLANF.GYEALQNLA...ETLPSLPSS
  779-  806 (30.36/15.28)	ERMASYlGLRSVRKLAlrpQDLAKLGAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.80|      10|     990|     186|     196|      16
---------------------------------------------------------------------------
  186-  196 (14.86/12.91)	KLLVLARWsKD
 1178- 1187 (19.94/11.96)	KLLVRVRW.QD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31414 with Med14 domain of Kingdom Fungi
Unable to open file!