<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31412

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMDEIHGEVSPPAINRSNGALVSDNISQVVEGVDNVERPAKVAKGYSAANRPPPELPHITNNVIPLSNVLKFYTQEAFKQITTLVENLASTKDSEDDSVRKKKFLELIIALRQDFIKIYTLVKWAANSKDVSRFIDLLNWLRMQEFYFDQLTFQLNALNGYSGAKLPNSDLITSLEVLFKGRPQLPSYNYIKIPKISPEKTLEVMQDLNLILMTRIALIDIPKRFINNYVIKDGRIYFSVPNEFQVSITVANDMIIESHDEYTKSPFYFIDFKFLFGINPDTSLITHRDNKIVTKLPRSSHENLEKIVNATLLNQGLHGLYDLLHKFSISFKLYLIAKQLKELQINTRWRNNLQVNYQNGKSLIILNYWSGQYLSKGWKSFIELGIDRNYNLNFRWFKNGKYNVNTELSALFNKHLKNTNEGEEEKDDSTDDIEEPEDLNVDLILNIVVNKHSELLMSKVFNSLDAKLNTTDNPDQISYITPHQLLIKSSPTKSTIFCINPLTGLFYFIDPCPVQNLIAKKINSPPTVVKNKNFVAESDMVNTIVDGLTQLRLEIFNKEIHNRLLTTEWINNDIIGLNDYEISRLSNFFANSLDYNLNVNKIQFYRRKNWPSSWFLINLVSGVTSVTFWWVARIKSVSGEWKIQWIQKLHLNEKTPSVEITDDPTNLNFEFFNNLSTACSNMIIDHMLLEELFKRNIKFLKVDNTALILQKFNIDKIPDDEDTQDTDDKNKPLIYESIIMIYNDNNLLPVYNSATSLFLKIKLINLNNLTQMKLKLFGKLRNLSIRNSPENFLQLNLKIDEIKNFFEIDDLINLSSRTNGSDSASSATTNHLLDKIFNNLNKLNKLIKILDQLNKNKIQIINNSVNDIIIKIDDNLDNLIIKLPEKATDSIKLISEEEVKDGGNPEVKLILDYLNKYLSNYYSDDFFANDEDKFYDGNKKTSIVGIIKYLKEINPILKSVQTIKAKLRKPESAFKLSNGLSKLNFDIKFTTLNLIQYVFHMNYQTPSSSKKIFKDKIVISLSFKNNKFDKVSKNLIKISLKDNLNSKNLKYKKLFELIFKSINDGSMDAHAHQLIKLNYDFLVNSSLVGELMVRIANCFVLYLQAESNGRYNQ
Length1112
PositionTail
OrganismScheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Debaryomycetaceae> Scheffersomyces.
Aromaticity0.10
Grand average of hydropathy-0.303
Instability index28.65
Isoelectric point8.56
Molecular weight128365.80
Publications
PubMed=17334359

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31412
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.17|      31|      39|    1001|    1037|       1
---------------------------------------------------------------------------
 1001- 1037 (46.33/26.73)	NYQTPS.SSKKIFKdkivisLSFK...NNKFDKVSKNLIKI
 1042- 1076 (43.84/16.98)	NLNSKNlKYKKLFE......LIFKsinDGSMDAHAHQLIKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     329.68|      82|     278|     381|     462|       2
---------------------------------------------------------------------------
  381-  462 (138.03/77.97)	IELGIDRNYNLNFRWFKN......GKYN.VNT..ELSALFNKHLK.....NT....NEGEEEK..DDSTDDIEEPEDLNVDLILNIVVNKHSELLMSKVFNS
  657-  752 (104.52/57.07)	VEITDDPT.NLNFEFFNNlstacsNMII.DHM..LLEELFKRNIKflkvdNTalilQKFNIDKipDD..EDTQDTDDKNKPLIYESIIMIYNDNNLLPVYNS
  780-  850 (87.13/46.23)	RNLSI.RNSPENFLQL.N......LKIDeIKNffEIDDLIN..LS.....SR....TNGSDSA..SSATTN.....HL.LDKIFN.NLNKLNKLI..KILD.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     246.68|      79|     219|     262|     351|       3
---------------------------------------------------------------------------
  145-  242 (119.30/68.06)	FYFDQLTFQLNALNGYSGAKLPNSDLITslevlfkgrpqlpsynyiKIPKISPEKtLEVMQDLNLILMTRIALIDIPKRF...INNYVI....KDGRIYFSVPNE
  266-  351 (127.38/86.53)	FYFIDFKFLFGINPDTSLITHRDNKIVT..................KLPRSSHEN.LEKIVNATLLNQGLHGLYDLLHKFsisFKLYLIakqlKELQINTRWRNN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.55|      16|      34|      77|      92|       5
---------------------------------------------------------------------------
   77-   92 (27.18/16.68)	FKQITTLVENLASTKD
  114-  129 (29.37/18.60)	FIKIYTLVKWAANSKD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.03|      31|      33|     882|     913|       6
---------------------------------------------------------------------------
  882-  913 (45.81/34.28)	LPEKATDSIKLISEEEVKDgGNPEVKL..ILDYL
  917-  949 (49.22/31.70)	LSNYYSDDFFANDEDKFYD.GNKKTSIvgIIKYL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.96|      11|     220|     545|     555|      10
---------------------------------------------------------------------------
  545-  555 (19.29/10.75)	DGLTQLRLEIF
  766-  776 (19.67/11.09)	NNLTQMKLKLF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.15|      12|      29|     102|     113|      11
---------------------------------------------------------------------------
  102-  113 (19.92/11.49)	KFLELIIALR.QD
  132-  144 (18.24/ 9.88)	RFIDLLNWLRmQE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31412 with Med14 domain of Kingdom Fungi
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