<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31411

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMENGHMNGVRTHHDRNSWTNGVNGGVAKREGSPDKGKAHANMSGSSVMMNGGGASFMDVDSQPPGGTKFNDLPDEIQHITADIMPLSLLLTRLSQWTHTKLQDEIAYLASKPLPQGVLNGTTNHQSADNHDTSQESLEKKVHLLNFLQDMHSKWVKTLVITEWSRKAAQVGALIDIRVHLLTKQAHYQELFWELIRMKQDLHWAKVPGPDLKTALEVLTTGQASWMPELGYIEPPPITWEEKEAFIDNINTMLSVRLTFDEHEKLPAAFRDYNIANGRVTFKVKGEFEVDLTIGDEDFEQQFWFIDFRFLFTPAPAELSHGVRTFLENKVNTILGDQGLAGCYNYLHEFVLTQKIIEFRRQATELAMGRWVDTLKVEKLNRAMSIQYWLKPPHGLEGPSSQTAKSWILLGVWSGKGVEGDLDSKPSSYISLRWFRDNKEVKDFDIPLNVETISAEKLLTAVIASHVEYILRSISSKLLSKPRFAQKHARLDLEISKEEPQNSSLAVQLFDNDKAVIKIEPLTGFFTMFPRSPVFLKGQMKLNTSSNVAEEGANLMEQLRFDHAVKDLNSRVRSIGWFVCRPPITQEETKTIVYSDASGSREAFKAVWLRKANWMTRQWFVMISMSLGGDQWWLVDLSPPKPNFPAGRLRLFTKMPMTSNQLTLSDTFFRNLSVYAAGMISHITDLRKLHTLKKSHTALELPNHSLPPQVRLPTIYVRLSEMLQQRPGSSSRTLTWAKDFVPIIFKGVRSHTGDQEGPADATAVRRDTPASIRAEARLTVIDRNKFKSLRGNVDHDVVYNHRTGQFSLKLRADMGTPVVDLLADRVQALERLMEFVEAIRLAGSNAIPQSVALREVVFTYSNDPAEPVVGPPQGPRAWNVHLDLPKDAKVVLTLEKGNPHIRALDMLQDMAQSTKTELLPSYLPFSLPLYRVLDRIEDEWESIAAKNAGNVAIVVKAAEWVTVRFTLPAPTTRRLLCLDIKTMGRKGRLLWHVKRTDEKGHERPLNAPQDEFDTLLQRSVWHAHGDGRKTFGTSAAADPKVGIETLLWSISESVKSLVGTLPPPPGTSPHPGGGTQDLQQGPQKTPQEMVAAQAAQAAQAAQAAQGMPPQRPKQQPPTPSQPQQQHRNVNQPQAQAQPQLHTQVQLQQAQVAQLQAQRQAQARANNSSNNNNTFVNRAHPGQPPQQRQSGPQTQAQQQQQRYQIQQQAQAMQRMQQQQQQQAAQQHAQQQGQGPQGQRSVHGQAGPQGVPQGQPGHGGGANGGMGGKNAPVVVID
Length1274
PositionTail
OrganismNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Sordariales> Sordariaceae> Neurospora.
Aromaticity0.07
Grand average of hydropathy-0.515
Instability index45.23
Isoelectric point9.14
Molecular weight142412.00
Publications
PubMed=12712197

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). 
ECO:0000250
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central
GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP31411
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      98.18|      18|      21|    1092|    1109|       1
---------------------------------------------------------------------------
 1088- 1105 (24.03/ 6.71)	MVAA..QAAQAAQAAQAAQG
 1106- 1121 (26.99/ 8.34)	MPPQ..RPKQ..QPPTPSQP
 1122- 1138 (24.38/ 6.90)	QQQH..RNVNQPQ.AQAQPQ
 1210- 1227 (22.78/ 6.02)	M..QrmQQQQQQQAAQQHAQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     104.79|      23|     117|    1064|    1086|       2
---------------------------------------------------------------------------
 1064- 1086 (46.05/23.61)	P.......................GTS................PHPGGGTQDLQQGPQKTPQ
 1157- 1195 (32.82/14.41)	R.......................QAQarannssnnnntfvnrAHPGQPPQQRQSGPQTQAQ
 1206- 1250 (25.92/ 9.62)	QaqamqrmqqqqqqqaaqqhaqqqGQG................PQ.GQRSVHGQAGPQGVPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     120.59|      32|     156|     569|     602|       3
---------------------------------------------------------------------------
  569-  602 (48.82/43.97)	SRVRSIGW...FVcrPPITQEETKTIVYSDASGSREA
  706-  727 (26.98/14.66)	...............PPQVRLPTIYVRLSEMLQQRPG
  728-  760 (44.79/31.44)	SSSRTLTWakdFV...PIIFKGVRSHT.GDQEGPADA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.71|      16|      70|     212|     233|       4
---------------------------------------------------------------------------
  212-  227 (28.76/26.75)	KTALEV.LTTGQASWMP
  250-  266 (23.95/ 7.35)	NTMLSVrLTFDEHEKLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     127.39|      38|      48|     408|     445|       5
---------------------------------------------------------------------------
  408-  445 (66.84/52.39)	LLGVWSGKGVEGDLDSKPSSYISLRWFRDNKEVKDFDI
  457-  494 (60.56/46.68)	LLTAVIASHVEYILRSISSKLLSKPRFAQKHARLDLEI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.66|      37|      39|     275|     312|       6
---------------------------------------------------------------------------
  275-  312 (60.05/44.12)	ANGRVTFKVKGEFE..VDLTIGDEDFEQQFWFIDfRFLFT
  314-  352 (58.62/37.80)	APAELSHGVRTFLEnkVNTILGDQGLAGCYNYLH.EFVLT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.77|      13|     213|     153|     165|      16
---------------------------------------------------------------------------
  153-  165 (24.62/20.07)	KWVKTLVITEWSR
  369-  381 (22.15/17.17)	RWVDTLKVEKLNR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31411 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MENGHMNGVRTHHDRNSWTNGVNGGVAKREGSPDKGKAHANMSGSSVMMNGGGASFMDVDSQPPGGTKFNDLPD
2) VKSLVGTLPPPPGTSPHPGGGTQDLQQGPQKTPQEMVAAQAAQAAQAAQAAQGMPPQRPKQQPPTPSQPQQQHRNVNQPQAQAQPQLHTQVQLQQAQVAQLQAQRQAQARANNSSNNNNTFVNRAHPGQPPQQRQSGPQTQAQQQQQRYQIQQQAQAMQRMQQQQQQQAAQQHAQQQGQGPQGQRSVHGQAGPQGVPQGQPGHGGGANGGMGGKNAPVVVID
1
1053
74
1274










Molecular Recognition Features






MoRF SequenceStartStop




NANANA