<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31410

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGVIMDNATVGRLGHAPDTQTPSNGDNLRNGSLHINGAAKGDKDHDPDKESYTGKPKIDGHRALPELPHITQGFFPFSTLVNRYVQQCWNELSDLITELAAIQVSPHSSMPLLPANGKSPGNQSPENVQKKLRILDFAHAKRAEFIKLLVLSQWSRRAHDVSKLIDLQNFIRSRHQAFVDALQRVGEMKRDLVQAQVANPDLQTALEILSKGRLESLADLGYKSSKLLTARGALKRLHRINRIISARLALHDSIPHPFRTYRVHDGRVTFVVRGEFELDLSVGAESELSQFFFVDIRFLYSPSSNIPNGRMSNEIDAKINDKLRDSGLTGCFNFLHGLVLTNKIHILFKQAIELAKGLWSETLRVELLHRTLVIQYWALKPGPKSWVEIGVKSGNGDADSQGVGVPCLGLRWMRDGQEVDSRDIEFDPEDLSMECLLRSVIALHISYLLSSAYGILSEYSLFSTGTLSSQAILNVTEPGECQLSVQLTGSRHLRVSIEPMSGAVTLSATPGLSERSESDASLDRSTIDDLVARVSRLRCIAAIEELESNVRILGFETVSPKGLRNEIRTVFPANVLRFSLFWHPSWERNWVVAATSSITGDNWWVVQLRRSSEVATDFSVSDTSVPLCSGHSMSDTFLATSHQTRSSSFPDLGYCLSGMVAIYANVSYLSDLQSVEFHPPLCALKVESDLQIPDIFIRYQVSKLPRALQLVLPAGLKRKNLLKDTVRLAFHGIDRHKNSAIFVAYGNLVGPWTDLCTLVSKSDSSLVFKRGGSGFALRLLAPAGRPVIVQLFKSLQTLECTLSILDFLRQRRLTPQSLSLTHIAFAYGPRRDLSAIIGIGLSEVPSSAELDPVRILARTDPLLFLTLGIRFKHPNPHRRVQGSLAAILNHASNEAGLDFVTEILSFTLPLMRALEQITSNASRQESFRLQVIVRNACTFLLHYTYQGFRFQLTTSQHSGQLTWVLRELSSPGAGPGHDQLKARLRGTLYHSNGNGWKGLGNGVVADVEGVSNVIWALDGCFTGAQHNTWLPRETKSDQDYSTQPVPEKQSQTGAPSQAAMANDTTITANFVNDKSLQRNPVASNAADVITID
Length1093
PositionTail
OrganismNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Fumigati.
Aromaticity0.07
Grand average of hydropathy-0.155
Instability index46.01
Isoelectric point8.52
Molecular weight120834.21
Publications
PubMed=18404212

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31410
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     169.79|      40|      71|     676|     716|       1
---------------------------------------------------------------------------
  627-  659 (53.53/35.81)	..........................PLCSGHSMSDTFLATSH.QTRSSSFP.DLGYCL.SG
  676-  716 (66.19/51.53)	VEFHP.....................PLCALKVESDLQIPDIFIRYQVSKLPrALQLVLPAG
  729-  785 (50.08/32.94)	LAFHGidrhknsaifvaygnlvgpwtDLCTLVSKSDSSL..VFKRGG.SGF..ALRLLAPAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.90|      12|      70|     240|     254|       3
---------------------------------------------------------------------------
  240-  251 (18.33/18.13)	RINRIISARLAL
  260-  271 (21.57/ 9.39)	RTYRVHDGRVTF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     161.32|      52|     687|     272|     333|       4
---------------------------------------------------------------------------
  272-  333 (72.55/75.34)	VVRgefELDlSVGAESELSQFFFVDIRFLYSPSSNIPNGrMSNEIDAKIND.klrdsGLTGCF
  965- 1022 (88.78/58.75)	VLR...ELS.SPGAGPGHDQLKARLRGTLYHSNGNGWKG.LGNGVVADVEGvsnviwALDGCF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     132.55|      41|      45|     824|     864|       6
---------------------------------------------------------------------------
  824-  864 (69.58/42.38)	IAFAY.GPRRDLSAIIGIGLSEVPSSAELDPV.RILARTDPLL
  870-  912 (62.97/37.68)	IRFKHpNPHRRVQGSLAAILNHASNEAGLDFVtEILSFTLPLM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.00|      20|     203|     377|     398|       7
---------------------------------------------------------------------------
  377-  398 (35.49/23.66)	YWalKPG.PKSWVEIGVKSGNGD
  582-  602 (34.51/17.55)	FW..HPSwERNWVVAATSSITGD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31410 with Med14 domain of Kingdom Fungi
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