<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31409

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAPVQLDNHQLIPPGGGGGSSGGGGSSSGSASAPAPPPPAAAVAAAAAAAASPGYRLSTLIEFLLHRAYSELMVLTDLLPRKSDVERKIEIVQFASRTRQLFVRLLALVKWANDAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPEVPWRLLKLEILVEDKETGDGRALVHSMQIDFIHQLVQSRLFADEKPLQDMYNCLHCFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKSLSLSVWNQQVLGRKTGTASVHKVTIKIDENDVSKPLQIFHDPPLPASDSKLVERAMKIDHLSIEKLLIDSVHARAHQRLQELKAILRSFNANESSSIETALPALIVPILEPCGNSECLHIFVDLHSGMFQLMLYGLDPATLEDMEKSLNDDMKRIIPWIQQLKFWLGQQRCKQSIKHLPTITTETLQLANYSTHPIGSLSKNKLFIKLTRLPQYYIVVEMLEVPNKPTQLSYNYYFMSVSTADREDSPVMALLLQQFKDNIQDLMSYTKTGKQTRTGTKHKLSDDPCPIDSKKAKRSGEMCAFNKVLAHFVAMCDTNMPFVGLRLELSNLEIPHQGVQVEGDGFNHAIRLLKIPPCKGISEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNGTSTREQGPSRHVYLTYENLLSEPVGGRKVVEMFLNDWSSIARLYECVLEFARSLPEIPAHLNIFSEVRVYNYRKLILCYGTTKGSSISIQWNSIHQKFHIALGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPQQQPFPKQPGTSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPATRLPGMSPANPSLHSPVPDVSHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTSVPPQEPVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAEMNPPRQGECTIFAAVRDLMANLTLPPGGRP
Length1459
PositionTail
OrganismMus musculus (Mouse)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Muridae> Murinae> Mus> Mus.
Aromaticity0.07
Grand average of hydropathy-0.173
Instability index53.52
Isoelectric point8.81
Molecular weight160963.92
Publications
PubMed=10512684
PubMed=16141072
PubMed=19468303
PubMed=15489334
PubMed=17132730
PubMed=21183079

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). 
ECO:0000250
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IDA:MGI
nucleoplasm	GO:0005654	TAS:Reactome
nucleus	GO:0005634	ISO:MGI
GO - Biological Function
transcription coactivator activity	GO:0003713	ISO:MGI
transcription coregulator activity	GO:0003712	ISO:MGI
GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	ISO:MGI
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	ISO:MGI
positive regulation of transcription, DNA-templated	GO:0045893	ISO:MGI
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central
stem cell population maintenance	GO:0019827	IMMGI

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP31409
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     216.48|      32|      32|    1041|    1072|       1
---------------------------------------------------------------------------
   31-   54 (26.05/ 6.91)	ASAPAPP..PPAAAVA.......AAAAAAA...SPG........
 1003- 1025 (27.86/ 7.92)	ISQLQPP..QQQPFPK.......QPGTSGA...YP.........
 1026- 1058 (30.44/ 9.34)	...LTSP...PTSY..hstvnqsPSMMHTQ...SPGNLHAASSP
 1059- 1092 (50.76/20.57)	SGALRAP..SPASFVP.....tpPPSSHGI...SIGPGASFASP
 1093- 1123 (53.10/21.87)	HGTLDPS..SPYTMVS.......PSGRAGN...WPGS.PQVSGP
 1124- 1151 (28.28/ 8.15)	SPATRLPgmSPAN..P..............slhSPVPDVSHSPR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.03|      24|      30|    1331|    1356|       2
---------------------------------------------------------------------------
 1331- 1356 (43.68/31.10)	PdqATQLKWNVQFC..LTIPPSAPPIAP
 1360- 1385 (39.36/21.43)	P..AVVLKSKMLFFlqLTQKTSVPPQEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     118.38|      30|      30|     122|     151|       3
---------------------------------------------------------------------------
   91-  118 (23.24/10.64)	..IVQFASRTRQ..LFV....RLLALvkwANDAgKV
  122-  151 (48.83/30.99)	AMISSFLDQQAI..LFVDTADRLASL...ARDA.LV
  153-  184 (46.31/28.99)	ARLPSFAIPYAIdvLTTGSYPRLPTC...IRDK.II
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.18|      31|     271|    1162|    1197|       4
---------------------------------------------------------------------------
 1162- 1197 (48.63/36.48)	NMPPPRKLPQRSWAAsIPTILThsalNILLLPSPTP
 1429- 1459 (58.55/30.68)	EMNPPRQGECTIFAA.VRDLMA....NLTLPPGGRP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.61|      11|      24|     773|     784|       6
---------------------------------------------------------------------------
  773-  784 (16.84/15.85)	LNDWSSIaRLYE
  800-  810 (19.77/12.81)	LNIFSEV.RVYN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.31|      28|      34|     515|     546|       7
---------------------------------------------------------------------------
  515-  546 (42.70/31.45)	IKHLPT..ITTETLQLANYSTHpigsLSKNKLFI
  548-  577 (46.61/24.76)	LTRLPQyyIVVEMLEVPNKPTQ....LSYNYYFM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.75|      12|      29|     365|     376|       8
---------------------------------------------------------------------------
  365-  376 (20.47/14.00)	IKIDENDVSKPL
  396-  407 (20.28/13.79)	MKIDHLSIEKLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.17|      31|      34|     213|     246|       9
---------------------------------------------------------------------------
  213-  246 (46.04/42.42)	DLPPQLANLTVAngrVKFRVEGEFEATLTVMGDD
  248-  278 (52.14/37.87)	EVPWRLLKLEIL...VEDKETGDGRALVHSMQID
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.60|      14|      35|    1252|    1266|      10
---------------------------------------------------------------------------
 1252- 1266 (21.47/16.05)	LKCRVALSP.KTNqTL
 1290- 1304 (22.14/11.28)	FETRVAGPPfKAN.TL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31409 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPQQQPFPKQPGTSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPATRLPGMSPANPSLHSPVPDVSHSPRAGTSSQTMPTNMPPPRKLPQRSWA
2) VQLDNHQLIPPGGGGGSSGGGGSSSGSASAPAPP
976
4
1175
37










Molecular Recognition Features






MoRF SequenceStartStop




NANANA