<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31408

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAAVMMNGVGPDGAMKPNLDQKLNNHGGDTKAISSSEIVQQQTPARSLQSDNPLRMNDLPDEIVHITENFLSLNQLLSRLAQRSHNELEDTIRSLAKKPLPMPPMLNGNADHNTIEDLSNENLDKKVTLLKFAQEQHAKWVKALVITDWSKKASTLSKLIDLKVHMHTQMEKYDFVLDRMMHNKRNLAYARLPSPDLKTALEVLANGDAPWMPDLGYIPPPEMSPEDQLKWLEDLDTLLSLRLTIDDHDKIPYHFRNYRIGSGRVTFIVKGEFEVDLTIADDDPEKQYWFIDFRFLFRPAPPGLSENLRMYLELKVNEVLGAEGLAGCYKYLHELVLTHKINELRRQAMELSVGRWVDALNVERLNRSLAVQYWTSRYPAKAPNAPKSWIIIGVHSAAPSGGLRATAPTSRLALRWFRDNQEVKDIEIPLDEADLSMERILKDVIGRHTQQILTLMHTGLRNKPRFVNKEDHLVLELSRKQPSESLLTMQLTKLDSMVVRVDQIGGTFAVQPRTRPMPMAESNLNTPGRDPVAVIGWVRNTFAMEELVRRGKSQGWVVGKPPVKPDDLRNILSNREQTDAMAWFRKQGWRPQFYVLAHLSMSGDQWWLIELTTPNSNSAASTAGGIRIRTHVQLQFASKQAIMESPSFFSDLNYFTSAMISKMRDLRELHSRRINHIDQPCIRPGLSSNIRMPTIFIRTSEVLPSLSGKGSLGRWAADEVRLSVANVQSSSSTEVDRRGENRSALSTRMDSRIVIASEARLRVLDKSKFRQLSSRVDRDVAFNHKTGEFVLQLRSELGETMIDKLISRLQTIERLYEFLGSISRAPRGVQCETVTLRRVVFTYSDLPQPVSEELAALQPPTKRWKVVLDFADPRTVKLVLEKNNPHIRAVDMLQTLANSPRGLERLPFYLPTTLAVYRALDSISDAWLQLQVSRKGTFEIFTKNIDLATIRYDLPGPQARRLTLDVKLVSRRGELSWHVKRTDAEPNKSNDEFSRVLKEVWNTKSPNWKSLSTSACGPASAGVEELLKGIDKAVRTLLESPPLVLQQQQQRQPVVQPGQQPQVQNQANGVMNRGPQRPGLPGAGGLGAQMRQKQVPQAPMGNHVVDLT
Length1108
PositionTail
OrganismMagnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Magnaporthales> Pyriculariaceae> Pyricularia.
Aromaticity0.06
Grand average of hydropathy-0.438
Instability index53.14
Isoelectric point9.42
Molecular weight125411.35
Publications
PubMed=15846337

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). 
ECO:0000250
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP31408
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     179.99|      62|      84|     657|     722|       1
---------------------------------------------------------------------------
  657-  722 (97.18/84.34)	SAMISKMrDLR.ELHSR.RINHIDQPCIRPgLSSNIRMPTIFI.RTSEVLpsLSGKGSLGRWAADEV..RL
  743-  809 (82.80/55.95)	SALSTRM.DSRiVIASEaRLRVLDKSKFRQ.LSSRVDRDVAFNhKTGEFV..LQLRSELGETMIDKLisRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.45|      19|      24|     826|     848|       2
---------------------------------------------------------------------------
  829-  848 (29.84/30.52)	VQCETVTLR......RVVFTYSDlPQ
  850-  874 (24.60/ 9.78)	VSEELAALQpptkrwKVVLDFAD.PR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.99|      14|      19|    1048|    1061|       3
---------------------------------------------------------------------------
 1048- 1061 (27.57/16.86)	QQQRQPVVQPG.QQP
 1064- 1078 (22.42/12.28)	QNQANGVMNRGpQRP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      89.50|      19|      19|     193|     211|       4
---------------------------------------------------------------------------
  193-  211 (33.97/21.37)	PSPDLKTALEVLA....NGDA.PW
  564-  583 (25.65/14.07)	KPDDLRNILSNRE....QTDAmAW
  585-  607 (29.88/17.78)	RKQGWRPQFYVLAhlsmSGDQ.WW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.69|      33|      82|     924|     957|       5
---------------------------------------------------------------------------
  924-  957 (55.55/38.63)	SDAWLQLQVSRKGT....FEIFTKNIDLAtIRYDLPGP
 1005- 1041 (53.13/32.34)	SPNWKSLSTSACGPasagVEELLKGIDKA.VRTLLESP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.64|      19|     118|     100|     118|       8
---------------------------------------------------------------------------
   71-   91 (26.15/12.31)	LSLNQLLSrlAQRSHNELEDT
  100-  118 (35.49/19.07)	LPMPPMLN..GNADHNTIEDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.10|      18|      20|     519|     536|       9
---------------------------------------------------------------------------
  519-  536 (31.14/23.46)	MAESNLNTPGRDPVAVIG
  542-  559 (31.95/24.31)	FAMEELVRRGKSQGWVVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.30|      16|      23|     303|     318|      10
---------------------------------------------------------------------------
  303-  318 (27.79/15.55)	GLSENLRMYLEL....KVNE
  324-  343 (24.51/13.02)	GLAGCYKYLHELvlthKINE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31408 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ELEDTIRSLAKKPLPMPPMLNGNADHNTIEDL
2) LESPPLVLQQQQQRQPVVQPGQQPQVQNQANGVMNRGPQRPGLPGAGGLGAQMRQKQVPQAPMGNHVVDLT
3) MAAVMMNGVGPDGAMKPNLDQKLNNHGGDTKAISSSEIVQQQTPARSLQSDNPLRMNDL
87
1038
1
118
1108
59










Molecular Recognition Features






MoRF SequenceStartStop




NANANA