<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31406

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAPVQLENHQLVPPGGGGGGSGGPPSAPAPPPPGAAVAAAAAAAASPGYRLSTLIEFLLHRAYSELMVLTDLLPRKSDVERKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDVPWRLLKLEILVEDKETGDGRALVHSMQISFIHQLVQSRLFADEKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGRKTGTASVHKVTIKIDENDVSKPLQIFHDPPLPASDSKLVERAMKIDHLSIEKLLIDSVHARAHQKLQELKAILRGFNANENSSIETALPALVVPILEPCGNSECLHIFVDLHSGMFQLMLYGLDQATLDDMEKSVNDDMKRIIPWIQQLKFWLGQQRCKQSIKHLPTISSETLQLSNYSTHPIGNLSKNKLFIKLTRLPQYYIVVEMLEVPNKPTQLSYKYYFMSVNAADREDSPAMALLLQQFKENIQDLVFRTKTGKQTRTNAKRKLSDDPCPVESKKTKRAGEMCAFNKVLAHFVAMCDTNMPFVGLRLELSNLEIPHQGVQVEGDGFSHAIRLLKIPPCKGITEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNGTSTREQGPSRHVYLTYENLLSEPVGGRKVVEMFLNDWNSIARLYECVLEFARSLPDIPAHLNIFSEVRVYNYRKLILCYGTTKGSSISIQWNSIHQKFHISLGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPPQQQPFPKQPGTSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPAARMPGMSPANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTSVPPQEPVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAEMNPPRQGECTIFAAVRDLMANLTLPPGGRP
Length1454
PositionTail
OrganismHomo sapiens (Human)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Homo.
Aromaticity0.07
Grand average of hydropathy-0.185
Instability index52.23
Isoelectric point8.97
Molecular weight160604.68
Publications
PubMed=9598311
PubMed=9989412
PubMed=10235266
PubMed=10024883
PubMed=15489334
PubMed=9734358
PubMed=10235267
PubMed=12218053
PubMed=11867769
PubMed=12509459
PubMed=15175163
PubMed=15340088
PubMed=15625066
PubMed=15989967
PubMed=16595664
PubMed=18691976
PubMed=18669648
PubMed=19369195
PubMed=19690332
PubMed=20068231
PubMed=21269460
PubMed=23186163
PubMed=16959974

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IDA:UniProtKB
membrane	GO:0016020	HDA:UniProtKB
nucleoplasm	GO:0005654	TAS:Reactome
nucleus	GO:0005634	IDA:UniProtKB

GO - Biological Function
nuclear receptor coactivator activity	GO:0030374	NAS:UniProtKB
transcription coactivator activity	GO:0003713	IDA:UniProtKB
transcription coregulator activity	GO:0003712	IDA:UniProtKB
vitamin D receptor binding	GO:0042809	NAS:UniProtKB

GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	IDA:MGI
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IDA:UniProtKB
positive regulation of transcription, DNA-templated	GO:0045893	IDA:UniProtKB
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central
regulation of transcription initiation from RNA polymerase II promoter	GO:0060260	TAS:Reactome
stem cell population maintenance	GO:0019827	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31406
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     256.77|      62|      64|    1002|    1063|       1
---------------------------------------------------------------------------
 1002- 1050 (85.54/34.00)	...........................................PPPQQQPFPKQPGTSGAYP..L.TSPPTSYHSTVN..QSPSMMHTQSPGNLHAA
 1051- 1115 (102.56/42.17)	SSPSGALRAP..SPA.......................sfvptPPPSSHGISIGPGASFASP..HgTLDPSSPYTMV....SPSGRAGNWPGS.PQV
 1116- 1201 (68.67/25.89)	SGPSPAARMPgmSPAnpslhspvpdashspragtssqtmptnmPPPRKLP...QRSWAASIPtiL.T......HSALNilLLPSPTPGLVPG.LAGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.84|      24|      29|    1326|    1351|       2
---------------------------------------------------------------------------
 1326- 1351 (45.04/26.94)	PdqATQLKWNVQFC..LTIPPSAPPIAP
 1355- 1380 (38.80/17.40)	P..AVVLKSKMLFFlqLTQKTSVPPQEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.08|      24|      29|     252|     280|       3
---------------------------------------------------------------------------
  252-  275 (40.30/32.31)	ILVEDKETGDGRALVH....SMQISFIH
  282-  309 (36.78/17.74)	LFADEKPLQDMYNCLHsfclSLQLEVLH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.33|      10|      24|    1402|    1411|       4
---------------------------------------------------------------------------
 1402- 1411 (17.56/11.09)	PRQQNSSVAA
 1428- 1437 (19.77/13.60)	PRQGECTIFA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     155.09|      51|     508|     329|     379|       6
---------------------------------------------------------------------------
  329-  379 (92.74/62.67)	YHAGKCLSLSV.WN...QQ......VLGRKTGTASVHKVTI.KIDE..N...DVSKPLQIFHDPPLP
  812-  878 (62.35/39.57)	YGTTKGSSISIqWNsihQKfhislgTVGPNSGCSNCHNTILhQLQEmfNktpNVVQLLQVLFDTQAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.19|      29|      30|      69|      97|       7
---------------------------------------------------------------------------
   69-   97 (46.39/39.72)	LTDLLPRKSDVERKIEIVQFASRTRQLFV
  102-  130 (48.79/42.24)	LVKWANNAGKVEKCAMISSFLDQQAILFV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.49|      14|      29|     168|     181|       8
---------------------------------------------------------------------------
  168-  181 (26.30/14.49)	RLPTCIRDKII....PPD
  194-  211 (19.19/ 8.39)	QLNQILRHRLVttdlPPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.88|      21|     396|     572|     592|      10
---------------------------------------------------------------------------
  572-  592 (36.25/21.58)	SVNAADREDSP....AMALLLQQFK
  977- 1001 (33.63/19.44)	SVNEDDNPPSPiggdMMDSLISQLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     134.64|      42|     396|     879|     926|      11
---------------------------------------------------------------------------
  879-  926 (61.26/52.84)	LNAINKLPTVPMLGLTQRTNTAYqCFSILPQSSTHIrlaFRNmyCIDI
 1278- 1319 (73.38/43.25)	LQVLEKFFETRVAGPPFKANTLI.AFTKLLGAPTHI...LRD..CVHI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.55|      28|      32|     509|     540|      16
---------------------------------------------------------------------------
  509-  540 (41.94/39.34)	IKHLPT..ISSETLQLSNYSTHpignLSKNKLFI
  542-  571 (45.60/30.45)	LTRLPQyyIVVEMLEVPNKPTQ....LSYKYYFM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     121.13|      40|     807|     397|     438|      18
---------------------------------------------------------------------------
  397-  438 (56.88/49.26)	IEKLLiDSVHARAH.QKLQElKAILRGFNANENSSIETALPAL
 1207- 1247 (64.25/45.44)	LERFL.GSVIMRRHlQRIIQ.QETLQLINSNEPGVIMFKTDAL
---------------------------------------------------------------------------











Associated diseases
Disease
cancer	PMID:33904398



























Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31406 with Med14 domain of Kingdom Metazoa
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