<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31405

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGVIMNQDNINGRGLGLHDQLNGVSSAPAGSSQLGNPVGLHNGSLPTNGVQHPDSRGSDENYRTKMMLSASGDPPELQHIVQGFFPLAKLLNRSAQQCWNDLADLVAELAEIQVPSHDSNFSPISPNTKVLGNQSPENVRKKLRALEFAQKKRGEFIKLLVLSQWSRQAADVSRLIDIQNFIRTQHQAYAGALQCMGDMKRDLVRAQVANPDLNTALEVLLRGEVVSMPDLGYRPPKPLTPKSTLKKMRKINRVISTRLALHDDIPLAFQKYRVHDGRVTFVVPGEFELDLSIGEEDVTSQFFFVDIRFLFSPSPSIPAGRMLSELDIKINDTLRNGGLSECFNWLHNLILTNKINILARQASELSRSLWSNVLRSELLHRTLVLQYWASKPNTKSWLEIGIRRGPRESTIGGMRPPSLGLRWIRDGQEVNSDDVEFDTDSLSVDRLLRSAIALHISHILSSAFRRISEKLLYSNGSLSLHAYLTRTEPGDCQLDVQLTASRRLRVAIEPLSGAIVLAATPNTLERVDTDRNMDRSTIDDIVSRVGRLRCAAAIEEVESQVKMLGFISVSPRNVRIDARSLFPANVLRFSFFWHHHWERSWLLAATSSMDGDKWWVVQTPSADSVTINRSLDAAVHHASSAVRSAQVICNLLLPAEQPDYSSLADLGHCLSGFLAIYANARFLQDLQFIKIWPHLEHLRIGPGLQVPDLNIEYEATKLPEALRVALPAGFKRKTFVKKTIRLAFHGIDRCRKVAIMVAYGNLSTSFPALGDLVAEDDHSLVLQKTGTGFALRLLASPGYPVVVALLESLQRLECVLSVYEILRRKKMDARFLSLSRLGFAYGPNKELLAQLDIGETQPQLPTEMDPLKLAFRTGHLFHYRLSISFDHSNPHRRIQGPLASNLNRPTAEAGLDTLTEILSFTLPLMQALDRFMANPSRNESSIVHVTVRNATSFQIHYPYEKCRLRLVAHQHQNQPVWVLRDVLSFQDGSCEPEFKHKLQERLYNSKGTGWRGLGNGVIAEPDHIGDLLDELDRCLASTKANTTPKALDSRTSHDAPAANNQSPAIRPEKSVEAADMHGGFVNRNLQQKAGPASQKTDVITID
Length1103
PositionTail
OrganismEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Nidulantes.
Aromaticity0.07
Grand average of hydropathy-0.250
Instability index48.14
Isoelectric point8.78
Molecular weight123040.11
Publications
PubMed=16372000
PubMed=19146970

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). 
ECO:0000250
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central
GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP31405
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     509.00|     192|     495|      66|     263|       1
---------------------------------------------------------------------------
   66-  167 (109.91/82.47)	......................................................................................................................................................................................KMMLSASGDPPELQHIVQGFFPLAKLLNRS.AQQCWND..........................................LADLVAELAEIQVPshdSNFSPISPNTKVLG..NQSPENVRKKLRALEFAQKKRGEFiklLVLSQWS
  168-  263 (124.01/76.22)	R.......................................QAA.................DVSRLIDIQNFIRTQHQAYAGA..LQCMGDMKRDLV.RAQVANPDLNTALEV.LLRGEVVSMPDLG..YRPPK.PLTPKSTL....KKMRK.................INRVISTRLALH.....................................................................................................................................................
  361-  599 (236.98/156.72)	R.......................................QAS.................ELSRSL.WSNVLRSEL..............LHRTLVlQYWASKPNTKSWLEIgIRRGPRESTIG.G..MRP......PSLGL....RWIRDgqevnsddvefdtdslsVDRLLRSAIALHisHILSSAFRRISEKLLYSNGSLSLHAYLTRTePGDCQLDvqltasrrlrvaieplsgaivlaatpntlervdtdrnmdrstIDDIVSRVGRLRCA...AAIEEVESQVKMLGfiSVSPRNVRIDARSLFPANVLRFSF...FWHHHWE
  600-  746 (38.10/16.29)	RswllaatssmdgdkwwvvqtpsadsvtinrsldaavhhaSSAvrsaqvicnlllpaeqpDYSSLADLGHCLSGFLAIYANArfLQDLQFIK.............IWPHLEH.LRIGPGLQVPDLNieYEATKlPEALRVALpagfK..RK...............tfVKKTI..RLAFH.....................................................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.67|      20|     242|     760|     779|       2
---------------------------------------------------------------------------
  760-  779 (36.68/20.05)	YGNLSTSFPALGD.LVAEDDH
 1004- 1024 (34.99/18.82)	YNSKGTGWRGLGNgVIAEPDH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     122.38|      40|     814|       5|      48|       3
---------------------------------------------------------------------------
    5-   48 (57.05/51.68)	IMNQDNINGRGLGLhDQLnGVSSAPAGS..SQLgnPVGLHNGSLPT
  822-  863 (65.33/41.22)	ILRRKKMDARFLSL.SRL.GFAYGPNKEllAQL..DIGETQPQLPT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31405 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GLGLHDQLNGVSSAPAGSSQLGNPVGLHNGSLPTNGVQHPDSRGSDENYRTKMMLSASGD
2) KANTTPKALDSRTSHDAPAANNQSPAIRPEKSVEAADMHGGFVNRNLQQKAGPASQKTDVITID
15
1040
74
1103










Molecular Recognition Features






MoRF SequenceStartStop




NANANA