<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31404

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAPTPLPLEQMSGVGGYLPAGQEGGPRINTMSMSMLIDFIIQRTYHELTVLAELLPRKTDMERKIEIYNYAARTRHLFTRLNALVKWGNSVSKVDKSSQIMSFLDKQNMLFVETADMLARMSRETLVRARLPNFHIPAAVEVLTTGTYNRLPTCIRERIVPADAITPAEKKQTLLRLNQVIQHRLVTGKLLPQMREFRIKNGRVTFEVKHEFSVALTVMGDSQNVPWRLLDIDVLVEDKETGDGKSLVHPLQVNYIHQLIQARLVENPNALSEVYNCLHYFCQSLQLEVLYTQTLRLNYERLDDNNITVEEYVPGVKLTVSYWRDLKSELGYRLTVQSDPSEIGRPLAVVHVPSLGAKESAEVADRAVRSEHLSMERLIVHTVYIRSVSRLSDLKLEFQAFLKDVDFNLQGTPAILTVPVLSPCLRAEQIHITIDTHTGMFRCHVPKHLDCPITDEMQEALNGDRSKLPSLLSELRYWITHRRCEKTLQHLPATATDTLTFLTQPEQELLQQGRHKIYVKLHRHPNIILVVQLKEKSTMANEMEYTFHLGFVAFQKDEADVIDDSAKQLVSVVAQPPSDIPKFFTKLMRLIEFDTFVATHGPGTEVDAEVSPHKRKSTGDILAPPAKQQKTIFPAYFIPELAHVVAMCDEKIPFMNLAQTLSKHNIPHSGLQVEANATSLVLKILALPQPGKSATAAGQQPQQGAASAAGTAPPSGSSAFPRIEPHVWDDLMRRVLSISVRSQTNKNSQVRIWVVEFVFYSTPLQSCHPKEQGSRRTVYLTYEQANHDFSKTVEELLNDWSKIVYLYTLVYDFAEQLRNKRLALCDMLVVKSYSYMNLLLGYGPKKEVSCNIYWSVQSHGFRLTFVGGMSAVNAHSMMRDQLAQHLNQQHSLTQIAQILHETYNPMSSIAKLPVLPFLGIPRPQVPVLSFCMLAQSPCLMRLTYQAVYCLELRFRANRLVSIRDGASSRFERNVIEEFTPIQGLKAFLSKYVDESAAYRGRAPHEDDNPLSPIGMEDNYGGPSSVTGVSAGGSSPFLGAGMRGPQSPRDSGLRFPAPHTPPSSSNPHTPASPHPSAGGGGAAQSHGNFNLTSPPAPHMPHPSPGGLMPSSPLNPQPSPHMVHSPGPNTLYMQSHQDSPFTAMSPANNQWPGSPSMPRPSPRPGQSPEHKSTGGSVVTGGPDRGGSRGTLNRPWAGAVPTLLTHEALETLCRPSPHPNKDINVTDMSPLERFLGCVYMRRQLHRNIQNEESLTALNSTEPGVVLFKVDGLQCQVMLNQMHMQTLHLKITQLPPPPDKPTFQLSPDDLLVIEQYFDTRVAAPPYRPNSLHSICRLLNLPAQVLKDFVQIMRLELKPEFGGDQLKWTVQMCMRMPPSAVPIVPSGNACVVLGRMKILFFLQITKIPFNGKDWKDSPSLVLPIVYDITMNLTQMAERREQVPSPMMTAASTLLRRFSEFNSQQNQCSLFPAITDLLTNLQLATDMPQPPPNQAIGPPVGVGVGVGVGIGVVGSSPNPMMPMQQLQPQVGPQGQVGPGGYPQLGPNPGGPQ
Length1546
PositionTail
OrganismDrosophila pseudoobscura pseudoobscura (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.07
Grand average of hydropathy-0.265
Instability index54.43
Isoelectric point8.44
Molecular weight171858.74
Publications
PubMed=15632085

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). 
GO - Cellular Component
mediator complex	GO:0016592	ISS:UniProtKB

GO - Biological Function
transcription coregulator activity	GO:0003712	ISS:UniProtKB

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	ISS:UniProtKB









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31404
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.17|      21|      37|    1035|    1062|       1
---------------------------------------------------------------------------
 1035- 1056 (38.49/14.32)	PFLGAGmRGPQSPRDSGLRFP.A
 1074- 1095 (28.68/12.27)	PSAGGG.GAAQSHGNFNLTSPpA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     151.21|      18|      47|    1102|    1119|       2
---------------------------------------------------------------------------
  707-  726 (23.86/ 7.38)	SAAGTAPpsGSSAFPRIEPH
 1102- 1119 (37.26/16.07)	SPGGLMP..SSPLNPQPSPH
 1125- 1139 (25.49/ 8.44)	GPNTLYM..QS...HQDSPF
 1144- 1161 (35.91/15.19)	PANNQWP..GSPSMPRPSPR
 1510- 1526 (28.69/10.51)	SPNPMMP..MQQLQPQVGP.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     254.52|      85|     476|     826|    1033|       3
---------------------------------------------------------------------------
  312-  428 (108.74/23.45)	YVPGVKLTVS.YWrDLKSElGYRLTVQSDPSEigrplavVHVPSLgakesaevaDRAVRSEHLSMER......LIVHTVY..IRSVSRLSDLklefqAFLkdvdfnlqGTPAIlTVPVLSPCLRAE
  842-  935 (145.78/212.10)	YGPKKEVSCNiYW.SVQSH.GFRLTFVGGMSA.......VNAHSM.........MRDQLAQHLNQQHsltqiaQILHETYnpMSSIAKLPVL.....PFL........GIPRP.QVPVLSFCMLAQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.84|      22|      31|     108|     129|       4
---------------------------------------------------------------------------
  108-  129 (36.33/27.24)	NMLFVETADMLARMSRETLVRA
  141-  162 (38.51/29.39)	EVLTTGTYNRLPTCIRERIVPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     328.93|      98|     503|     732|     840|       7
---------------------------------------------------------------------------
  732-  833 (160.71/103.64)	MRRVLSisvRSQTNKNSQVRIWVVE..FVFYSTPLQSCHPK.EQGSRRTVYLTYEQANHDFSKTVEELLNDWSKIVYLyTLVYDFAEQL.R.....NKRLALCDMLVVKSY
 1180- 1231 (51.82/23.02)	.......................................PD.RGGSRGT..................LNRPWAGAVPT.LLTHEALETLcRpsphpNKDINVTDMSPLERF
 1237- 1312 (116.40/63.49)	MRRQLH...RNIQNEESLTALNSTEpgVVLFKVDGLQCQVMlNQMHMQTLHLKITQLPPPPDKPTFQLSPD................................DLLVIEQY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     383.33|      98|     476|     936|    1033|       8
---------------------------------------------------------------------------
  936- 1033 (166.73/107.29)	SPCL.MRLTYQAVYCL.ELRFRANRLVSIRDGASSRFER......NVIEEFTPIQGLK...AFLSKYVDESAAYRGRAPHEDDNPLSPIGMEDNYGGPSSVTGVSAGGS
 1322- 1384 (69.14/39.08)	....................YRPNSLHSIC........RllnlpaQVLKDFVQIMRLElkpEFGGDQLKWTVQMCMRMP..................PSAVPIVPSGNA
 1412- 1509 (147.46/93.82)	SPSLvLPIVYDITMNLtQMAERREQVPSPMMTAASTLLR......R.FSEFNSQQNQC...SLFPAITDLLTNLQLATDMPQPPPNQAIGPPVGVGVGVGV.GIGVVGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.23|      14|      93|      72|      86|       9
---------------------------------------------------------------------------
   43-   56 (24.19/ 7.45)	RTYHELTVLAELLP
   73-   86 (24.04/11.23)	RTRHLFTRLNALVK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31404 with Med14 domain of Kingdom Metazoa
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