<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31400

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGLAMDGPSAMASRATVADMHYDPASASQQANGGIYRNGIGKKSHSPVDGLHDSHIGCLHELPPELSHITLGFFPFNNLISRVVQQSWNDLNELLNEMGSSQAYQTGISSQLSATKNGMSEKFRGDQATENSLKKLRILEFTHSRRAEFIKLLVLSQWSRQANEVSRLIDIQAFIRMRSGFYEAALFHIGNMKQNLIVAQLANPDLKTASHVLSAGKIDALHGLEFLSPRPLAPSQVLRLLRGINKLIDMRLALHDHVPDSLQNYFVHDGRVTFIVPNEFEIDLSVASAAPSAQFFLVDMKFLFFPSSLPKGRLRSIVDHQVNSTLMNAGLVGCFNLLHNLILTHKITILFKQAIDLARTYWSEHLRVELFHRTLVLQYWSKKPGGKSWIEIGVHSGLKGSPQSTGTTTSFLQLRWFRDNEEVSATDIDFNLTFLSAKSILFSAISLHITHILRTAFEALRQNRLYCLGGLYIGMSASSKEPGDCYLELQMTQTSHLDIMVEAVSGDTVLRVAPSPITRYDTEIIVDRGSVEDIVERVSRLRCVSALEEVERYAKAVGWMPLNLRHVNLESLKRIFPPSALRSMLLFRAKCWEPSWLAVFTSAMDGDNWWIVQLQTQNPPALQSHWRLLEAQRAKLITGWFTGWLGRLHNASFSSLLSALSGMIMVQCNVDFLNEIGAIHFFPPPKDLLLQPCLRVPSIYLRLRHDDFPSQFRTIFSGGSPRRSFIDETFRISYKGIDQQSGHAITMVYGRLMTDIDMFGALYAKSVQDIAFQPKGRGFAILFRTPVGTPIIAPLLERLQQMNNIAFVVESMKSQGFQPHSLSPLRIKFSYPTQGELRGSIKFIYHDQGSHFESKLLFPATTTKPILHPRIGIDFNYQNPHRRITESLSTILNSHKDGMSLVLELINITLPLLVTLERICAEEYIDNAWCFRAQYTARSARLYQIRYPFLRYRFNVSASQRKSYVVWVIQNSTPGPERSKHPSLELRLKDQIYNSQGDGWRGINQGAMAYSANVSRLVFDLHQLMKSYISQMAKSNQRGEPTDSSPSAGCEFGRYLPKNENKKGHIQTTTAPTLEHAYGNSNMVVQSVRQGEAAARDVDVIAID
Length1105
PositionTail
OrganismCoccidioides immitis (strain RS) (Valley fever fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Onygenales incertae sedis> Coccidioides.
Aromaticity0.09
Grand average of hydropathy-0.163
Instability index47.55
Isoelectric point9.17
Molecular weight124581.51
Publications
PubMed=19717792
PubMed=20516208

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). 
ECO:0000250
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP31400
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     188.34|      63|      74|     398|     468|       1
---------------------------------------------------------------------------
  398-  468 (92.63/80.81)	GLKGSPQSTGttTSFLQLRWfrdnEEVSATDIdfNLTFLSAKSIL...FSAISLHITHIL..RTAFEAL..RQNRLYC
  475-  544 (95.71/60.83)	GMSASSKEPG..DCYLELQM....TQTSHLDI..MVEAVSGDTVLrvaPSPITRYDTEIIvdRGSVEDIveRVSRLRC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     197.14|      66|      76|     166|     240|       2
---------------------------------------------------------------------------
  166-  240 (98.95/80.01)	VSRLIDiqafirMRSGFYE...AAL..FHIGNMKQNLIVAQLANPDLKTASHVLSAGKIdaLHGLEFL.SPRPLaPSQVLR
  245-  316 (98.19/58.62)	INKLID......MRLALHDhvpDSLqnYFVHDGRVTFIVPNEFEIDLSVASAAPSAQFF..LVDMKFLfFPSSL.PKGRLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.44|      33|      74|     761|     795|       3
---------------------------------------------------------------------------
  761-  795 (50.97/36.19)	GALYAkSVQDIaFQPKGRGFA..ILFRTPVGTPIIAP
  836-  870 (56.46/31.81)	GELRG.SIKFI.YHDQGSHFEskLLFPATTTKPILHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     149.74|      43|      78|     548|     592|       4
---------------------------------------------------------------------------
  548-  587 (61.37/31.91)	.......................................LEE..VERYAKAVGWMPLNLRHVNLES.LKRIFPPSALRSMLL
  590-  666 (48.17/26.68)	AKCwepswlavftsamdgdnwwivqlqtqnppalqshwrLLE..AQRAKLITGWFTGWLGRLHNAS.FSSLL..SALSGMIM
  667-  723 (40.20/15.78)	VQC....................nvdflneigaihffppPKDllLQPCLR.VPSIYLRLRHDDFPSqFRTIFSGGSPR....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.65|      12|      17|     351|     364|       5
---------------------------------------------------------------------------
  351-  364 (18.45/17.66)	LFKQAIDLArtYWS
  371-  382 (24.20/15.20)	LFHRTLVLQ..YWS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.91|      15|     598|      49|      65|       6
---------------------------------------------------------------------------
   49-   65 (26.52/21.01)	VDGLHDshIGCLHELPP
  671-  685 (30.39/17.01)	VDFLNE..IGAIHFFPP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31400 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MAKSNQRGEPTDSSPSAGCEFGRYLPKNENKKGHIQTTTAPTLEHAYGNSN
1033
1083










Molecular Recognition Features






MoRF SequenceStartStop




NANANA