<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31399

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMDNSVHNNSNTTHPDKSRASIVNGVREERVSLSTEPPAGVKGGDNGPITVGDYNKLESRLQGAGMEDSVDELQHITDDVMPLSLLLSRLAQFSHLKLQELILDLASKPLPENTLNGNAKGSMNSSINGNVNAGVNGVPKLPSPALEDTSPESLNKKTMILKFIQDLHSRWVKALVITEWARNADEVGKLIDLRTHLAAKLELYNRAFWNMVNLKHEMAFAKVPSPDLKTALEVLSTGAVHWMPDFGYLPKPPLTTQETLHWLNEIEVVLHMRLQLHEYEQIPEPWKEYKIDNGRVTFTVPGEFEVDLTISDEDFDKQFWFLDYRTIFSPSPSKLSDGARGFIEARVNTILETEGLLGCYKYLHELTLTTKIGEFARQAVELSRTGLWTQTLRVERLNRALGIQYWSQSLHTQDSQSWILLGVHSGKSSDGADDPSSPSRLMLQWFRDGKEVKDADIPLDTDTISTEKLLMTVISRHIKYLLSSIYNSLSSKPRYAQKRGRLSLRISDPPHLDCALTMQTLGADHAVLGIGPWSGNFFFADRPPFGVGWANKINTLRNPVTEAPVVLEQLRWYHMTLHLRTLPKPADWKVLPKAPVPLDEVKRVVYSRASTTREPFHAIFLRNSRWTPQWFAMMSLSLGGDRWWTAEGHGIPGLRINIFTELSITPTDLLLPSSPLFSKLTQHATNIMDQIHDFRVLHQQHIQYTARKASPDGHRTTVVLSADMLPLQPDPDGTTQPTWAGRFIQLDYKGPAPITPSEYRESLADPKSVRRQPTRQKVMIEATVGVLHPTKFRLLRHRLDRDVLYDRRLGHFTLRFQPASGAGIIPLLRSRVQSLDRLVDIVDALHLRGKQISPKKITLREIVFSYGNGSPTMSLSNPRPKFGGNKQRSWEVRLNLAAEQGVDVILEAGNPHLRAIDYLRSAANSVHLKKLPAWFVFTLPLYEALEQLHDSWDAILAKDLGTCYVFHKSLDWLTIRFALSGAKNRLVQLDIRPRDRNGHINWHISRAKTDPNINNENDEFNKILKQRVWSISGNGFKGLGNSATAQWDHGIGPLLAVINEALQSLAGTPPPPQVPTQIQQPQQPSPHPQQAQVQEQRQQPQQQQQANPLQGAAVPGRFPHQLQQGQQLSYQQQARLQQQQRQQQQQQQQQQHMHNQNQAQQAQQRAAMNDINTPVVVLD
Length1178
PositionTail
OrganismChaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Sordariales> Chaetomiaceae> Chaetomium.
Aromaticity0.07
Grand average of hydropathy-0.481
Instability index48.17
Isoelectric point9.02
Molecular weight133114.74
Publications
PubMed=25720678

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). 
ECO:0000250
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP31399
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     134.42|      15|      17|    1068|    1082|       1
---------------------------------------------------------------------------
 1068- 1082 (32.20/17.55)	PPPPQ...VPTQIQQPQQ
 1084- 1101 (25.68/12.32)	SPHPQqaqVQEQRQQPQQ
 1112- 1126 (26.57/13.04)	AVPGR...FPHQLQQGQQ
 1128- 1142 (25.32/12.03)	SYQQQ...ARLQQQQRQQ
 1151- 1163 (24.66/11.50)	HMHNQ.....NQAQQAQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.40|      33|     124|     405|     446|       2
---------------------------------------------------------------------------
  408-  440 (59.67/41.58)	SLHTQDSQSW.........ILLGVHSGKSSDGAD..DPSSP..SRL
  634-  679 (42.72/12.94)	SLSLGGDRWWtaeghgipgLRINIFTELSITPTDllLPSSPlfSKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     495.33|     118|     256|     500|     629|       3
---------------------------------------------------------------------------
  500-  624 (198.90/142.29)	RLSLRISDPPHLDCALTMQTlGADH..AVLGIGPWSGN....FFFAD....RP.PFGV...GWANKINTL..RNPVTEAPVVLEQLR..WYH.MTLHLRT...LPKPADWKVLPKAPVP.LDEVK.RVVYSRA..STTrepfhaIFLRNSR
  681-  797 (118.47/67.66)	QHATNIMDQIH.DFRVLHQQ.HIQY..TARKASP.DGHrttvVLSADmlplQPdPDGTtqpTWAGRFIQLdyKGP...APITPSEYR...ES.LADPKSV...RRQPTRQKVMIEATVGvLHPTKfRLLRHR...................
  799-  878 (101.15/59.81)	.......................DR..DVL.YDRRLGH....FTLRF....QP.ASGA...G...IIPLL..RSRVQS....LDRLV..DIV.DALHLRG...KQISPKK.......IT.LRE....IVFSYGngSPT......MSLSNPR
  890-  971 (76.81/49.84)	EVRLNLAAEQGVDVIL..EA.GNPHlrAIDYLRS.AAN....SVHLK....KL.P......AWF..VFTL....PLYEA...LEQLHdsWDAiLAKDLGTcyvFHKSLDW.........................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.97|      31|     382|      76|     108|       4
---------------------------------------------------------------------------
   76-  108 (46.29/39.87)	TDDVMPLSLLLSRLAQfsHLK..LQELILDLASKP
  460-  492 (46.68/32.57)	TDTISTEKLLMTVISR..HIKylLSSIYNSLSSKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     110.21|      27|     105|     140|     167|       5
---------------------------------------------------------------------------
  140-  167 (42.69/33.98)	LPSPALEdTSPES...LNKKTMILKFIQDLH
  223-  240 (26.52/14.56)	.PSPDLK.TALE..........VLS.TGAVH
  248-  276 (41.00/27.01)	LPKPPL..TTQETlhwLNEIEVVLHMRLQLH
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31399 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) INEALQSLAGTPPPPQVPTQIQQPQQPSPHPQQAQVQEQRQQPQQQQQANPLQGAAVPGRFPHQLQQGQQLSYQQQARLQQQQRQQQQQQQQQQHMHNQNQAQQAQQRAAMNDINTPVVVLD
2) MDNSVHNNSNTTHPDKSRASIVNGVREERVSLSTEPPAGVKGGDNGPITVGDYNKLESRLQGAGMEDSVDELQ
1057
1
1178
73










Molecular Recognition Features






MoRF SequenceStartStop




NANANA