<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31397

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPNGKQQHEVTESSSPPEIPHITANMIPLSNIIKYYTQEAYKQLTTAIENLSMNVNEESDIKRKKYFLNVIINLRQDFIKVYTLIKWASISKDVSKFIDLLNWFRIQEFHFENLIFQLNALTGYNAAKLPNSDIITALEVLYHGRPKLPSYNYIKSDNLSPQKILETLNDLNLVLMTRFALMDNIPKRFDYEIKDGRAYIRVSNEFEVSITVGNDLIIDNPEEYYKSPFYFIDFKFLFGANPESGLITFNDDKISTKLPTSSHKKLEKLVNQTLLTRGLQGLYELLHKYSNSFKIYLLAKQFQTLLINSRWRGNFQINYQTNKSLIVINYWSQHYLSRNWKSFIELGIDSHSNLNYRWFKNGQYCFGDQGNNELDKIFHLQRRNSNNGVTTSSNTISTSAMIAGIRRSTELSNETAIVDDNDNDNDDTNNTGETENEDLNVDLILNVVVNQHAKSIMSEIYSQLLTRFSETDVSMVSPHQLLLQISPKKSTVFAINPLTGFFYFIDPTPIQTYITKKINSPPPTLSQVSIKQSFIPESDMISYVIDQIIQLRLEVFNKEVNTKLATTAWINNGIIKLSDHELSKLTQFLIQNEEQEGDDNEEDSSTNTRLDSVLQSFKVQFYRRKNWPSSWFLINMISGVTTKSFWWVARIKSISGDWKIQWAQIIKFHGDNAKQELSPNESKVFDKPKRTVDCSIESEQLNFEFFKTLSTLSSNLILDHMILEELQVRSIKFIKLDWETIDDNKIFSKFKQNHDISLKRKNSHNINIDVNVDVADNTSTTTNTKYIRAPKLKYESMFLIYNDKLLPIYNSATILFLKIELVESNKMYLKLFGNLRNLQIKNTSEDIQKLHLNIDEANQYFEIDNTVDLSTVINEPKTLLLNLIFNTLNKLNSLIKILDQLNKSNVTVLDNSMDNITINIKDKYNDNNDKLIIIKLPEQATDSIQLLMKNGSTTTTDEIDLRNNNILEFELILKFLNQYLRESKSNNHNRQQISIIKIIQYLTEINPILQSTKAINQQLAELKRINSTNNNNNNAKRRSILKLSNGLYKLYFNLNIISLTHLQLVFFMNSNTGSNLKKIQRDKIMINLSLIKFDRFSKPNGNFQDSTNGHLIKISFKDSLINENLKFKNLFEIIFKNINELLITKSKQIKSLNQTENQQQQQPLKQEDNSDSAIIKKESQSIEDDLLDFGEYDNDIKPQQQEPQQNEKENSKTTSKENETVRPDDILIKLNYDYLLSMNNLQLMINEITKSCFQYLQQQQE
Length1261
PositionTail
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Debaryomycetaceae> Candida/Lodderomyces clade> Candida.
Aromaticity0.09
Grand average of hydropathy-0.484
Instability index39.53
Isoelectric point6.44
Molecular weight146556.68
Publications
PubMed=15123810
PubMed=17419877
PubMed=24025428

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). 
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31397
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     471.60|     158|     264|     157|     419|       1
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   87-  263 (241.35/262.30)	WAS.ISKDVSKFIDL.LNWFRIQEFHFENL.......IFQLNALTGYNAAKLPNSDIIT.ALEVLYHGRPKLPSYNYIKSDNLSPQ....KILETLN.DLNLVLMTRfALMDNIPKRFDYEIkdgraY....IRVSnEFEVSITVGNDLIID.NPEeyyKSP..........FYFIDfkflfgANPESGLITfndDKISTKLPTSSH
  340-  527 (230.25/179.49)	WKSfIELGIDSHSNLnYRWFKNGQYCFGDQgnneldkIFHLQRRNSNNGVTTSSNTISTsAMIAGIRRSTELSNETAIVDDNDNDNddtnNTGETENeDLNVDLILN.VVVNQHAKSIMSEI.....YsqllTRFS.ETDVSMVSPHQLLLQiSPK...KSTvfainpltgfFYFID......PTPIQTYIT...KKINSPPPTLSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.03|      34|      38|    1159|    1193|       2
---------------------------------------------------------------------------
 1159- 1193 (54.76/39.70)	QQQQPlKQEDNSDSAIIKKESQSIE.DDLLDFGEYD
 1199- 1233 (54.27/34.65)	QQQEP.QQNEKENSKTTSKENETVRpDDILIKLNYD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     218.87|      72|      81|     591|     669|       3
---------------------------------------------------------------------------
  591-  668 (118.73/91.62)	QNEEQEGDDNEE...DSSTNTrLDSVLQS..FKVQFYRRKNWPSSWFLIN.MISGVTTksfwwVARIKSISGDWK.IQWAQII.KF
  671-  750 (100.15/57.09)	DNAKQELSPNESkvfDKPKRT.VDCSIESeqLNFEFFKTLSTLSSNLILDhMILEELQ.....VRSIKFIKLDWEtIDDNKIFsKF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     459.90|     137|     263|     758|     900|       4
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  758-  900 (212.52/130.17)	LKRKNSHNiNidvNVDVADNT..STTTNTKyIRAPKLKY.ESMFLIYNDKL..............LPIYNSATILFLKIELVESN....KMYLKLF......GN.LRNLQiKNTSEDIQKLHLNI......DEANQYF.EIDNT....VDLS...TVINEPKTL..LLNLIFNTLNKL....NSLIKILDQ
  905- 1021 (114.11/56.22)	.............NVTVLDNSmdNITIN...I...KDKY.ND....NNDKLiiiklpeqatdsiqLLMKNGSTTTTDEIDLRNNNilefELILKFL......NQyLR....ESKSNNHNRQQISI......IKIIQYLtEINP.............ILQSTKA..............I....N...QQLAE
 1022- 1154 (133.27/68.08)	LKRINSTN.N..............NNNNAK..RRSILKLsNGLYKLY.....................FNLNIISLTHLQLV............FFmnsntgSN.LKKIQ.....RDKIMINLSLikfdrfSKPNGNF.Q.DSTnghlIKISfkdSLINENLKFknLFEIIFKNINELlitkSKQIKSLNQ
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.49|      29|     505|      22|      50|       6
---------------------------------------------------------------------------
   22-   50 (50.44/30.09)	ITANMIPLSNIIKY............YTQEAYKQLTTA..IEN
  530-  572 (37.04/20.17)	IKQSFIPESDMISYvidqiiqlrlevFNKEVNTKLATTawINN
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31397 with Med14 domain of Kingdom Fungi
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