<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31396

Description Isoform a of Mediator of RNA polymerase II transcription subunit 14
SequenceMSSNVLPMYASTPSRAFAHSKLSSQLRAALADNSPAAPISPAPSGSALSLDESSGISDRDVHSSQEQTAHLSEVDVKSIHSSDSEDEPAQNPLPEVPANCGPPTIPLNVLLDFAIQHVYHEITVLAELMQRKTNDQGEQERKMSLVHFAHATRSQFLKLVALVKWIRISKRMDVCYSIDYLLDLQSQYFIDTADRLVAMTRGDLELARLPEYHIAPAIDVLVLGTYNRMPSKIKEAFIPPAKITPREQKLVTSRLNQLIESRLSRLSSGIPPNIKEIHINNGLATLLVPGEFEIKITLLGETEMTKWTLLNIKILVEDYELGMGLPLVHPLQLNQLHGVLQSRMNVSLNPIKEAFSFLHSFCVSLQLDVLFCQTSRLAAGRLRDNITIEKYDPKERVLVVGYWVKRSKSRRLTVGQVKCDAQYRVQIYEDPNDKLGGLKVRHFPHAPQLGRLDSGAGMLSIDRLLSETYVVRCKERLMRLRRILEAAEPRLEVKMTGISAPSLSLALLPDTSSKDEMMTVSVNSFCGKVLCNVHILSAEHEDVLAFGKALYSSQCSAHTIQMYLRKLRVALVIERYRRSVKALPVREVQEAELLPFAKECLGDAPAQRIILQFLRSEDYYLLVTFSPDEKAVVKTHIQLLEVVGDRAQFIQLEDDEMNGMHVKEAINQGTMRFSPSHKTSLQEECSREQRLAFAVATVEDRITYMYLAAELMKKGIGVDVRKDSAHVPGGLALHITDVKNVVPFEASEFFECCIRCCLRLDNRNRYTFQFEMCFENIPLVRDVPHGLPHRRDGEPKDRTSKDATWLQELNHINQSSPEKLVELIIHRLMRYLYMYKVVHQFSLAYEKHFKNYCNIEAYTFHKLVVSYGDNRDMLMILAFNVKSQAPGSSEDFFFLNFGQSMPHRQFNSTEIDWHQKPRWNPHSMMSQLMRDDLKETNDLVFTMHFLCETIRPLVAIGNFSRIRFQSQKSLSQLIGPDVHFPFRLKYHLYALDQTTLRLMQGNVILEIKLLEGCKIAVRDVSRYRPRCAGLFQLFSNIDSETTAIMNDEIAIPQSDNPQTAGPTMWTPEQFMDSLDERPEEIDPRMAITSQPILMSHDTIIKACDFKDTEGRITCPLDEYLCSISYLQRALLTLERMSPRATLNKNSSSNLSCGFVTIIDAKPDFIRFRASQMNGDGVNATSMVHYKIYLCPVAMTLKIRIEFEEGTNSAATADNLKTLTTYFEKVVFPCGDEYALQSYICLTRLTSFEATQSIANLMNVQMEHPPTSKCCVQLSLTYNNTSTKKLAPATKVDQPLQNIIFNVIVSQSRTSESFSVLRFIYRIKENFVVVPSANEKNKQMADEVNAETKTSGGNPIWNLVRLVMDRFNSGDWNPGNRDEPIISSVAPPTYVNPGSVAGPSSVAAPGSVSIQQPGSVLQPGSMMGPQSVNALQYGMHRQPMGGPQSMQMNPSSVGQPGSVGGPGSHQQHMMNPGSVGPGSVGGPGSVNPGSVGYPQWNPPSVGQSYHHPLHHQQYPPQ
Length1382
PositionTail
OrganismCaenorhabditis elegans
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Rhabditina> Rhabditomorpha> Rhabditoidea> Rhabditidae> Peloderinae> Caenorhabditis.
Aromaticity0.07
Grand average of hydropathy-0.258
Instability index49.79
Isoelectric point6.87
Molecular weight170398.63
Publications
PubMed=7906398
PubMed=9851916
PubMed=12089139

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for transcription in the embryo and for phosphorylation of the RNA polymerase II C-terminal domain repeat. 
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats
>MDP31396
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     203.77|      19|      19|    1444|    1462|       1
---------------------------------------------------------------------------
 1368- 1387 (25.37/11.69)	...SGD...WNPGNRD........EPiiSSVAPP
 1390- 1404 (23.27/10.05)	.........VNPGSVA........GP..SSVAAP
 1405- 1418 (19.88/ 7.40)	GsvSIQ..................QP..GSVLQP
 1419- 1442 (27.13/13.07)	G..SM....MGPQSVNalqygmhrQP....MGGP
 1443- 1461 (43.01/25.49)	Q..SMQ...MNPSSVG........QP..GSVGGP
 1462- 1482 (38.25/21.77)	G..SHQqhmMNPGSVG.........P..GSVGGP
 1494- 1507 (26.85/12.85)	.....Q...WNPPSVG........Q....SYHHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.74|      24|     111|    1111|    1142|       3
---------------------------------------------------------------------------
  367-  394 (37.25/17.71)	LDVLFCQTSRLAagrlRDNITIEKYDPK
 1116- 1139 (42.50/27.21)	LDEYLCSISYLQ....RALLTLERMSPR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.76|      18|      24|     959|     980|       4
---------------------------------------------------------------------------
  918-  935 (34.38/17.67)	RWNPHSMMSQLMRDDLKE
  963-  980 (31.38/15.06)	RFQSQKSLSQLIGPDVHF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.61|      22|     335|     848|     870|       6
---------------------------------------------------------------------------
  848-  870 (40.31/30.48)	HFKNY.CNIeAYT..........................FHKLVVSYGDN
 1184- 1232 (27.30/14.91)	HYKIYlCPV.AMTlkiriefeegtnsaatadnlktlttyFEKVVFPCGDE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.60|      21|     513|     642|     662|       9
---------------------------------------------------------------------------
  642-  662 (37.31/19.62)	VVGDRAQFIQLEDDEMNGMHV
 1157- 1177 (37.29/19.61)	IIDAKPDFIRFRASQMNGDGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.97|      27|      42|    1251|    1277|      12
---------------------------------------------------------------------------
 1251- 1277 (49.33/37.16)	QSIANLM.NVQMEHPPTSKCCVQLSLTY
 1293- 1320 (40.64/29.09)	QPLQNIIfNVIVSQSRTSESFSVLRFIY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.07|      21|      26|     209|     229|      13
---------------------------------------------------------------------------
  209-  229 (36.83/22.96)	LPEYHIAPAIDVLVLGTYNRM
  238-  258 (35.23/21.64)	IPPAKITPREQKLVTSRLNQL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31396 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NPGSVAGPSSVAAPGSVSIQQPGSVLQPGSMMGPQSVNALQYGMHRQPMGGPQSMQMNPSSVGQPGSVGGPGSHQQHMMNPGSVGPGSVGGPGSVNPGSVGYPQWNPPSVGQSYHHPLHHQQYPPQ
2) RAALADNSPAAPISPAPSGSALSLDESSGISDRDVHSSQEQTAHLSEVDVKSIHSSDSEDEPAQNPLPEVPA
1391
27
1516
98










Molecular Recognition Features






MoRF SequenceStartStop




1) LRAAL
26
30