<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31395

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMNNIPIKMSLDFFVFCFGQSEKLSSQLRGALAADSPAMAARSSLDPTGSVLSLDESSGISDHEGFSSAEQDNFSNRKPEDQAKNSSDSEEDVEAKNPLPDVPPGCGPPTIPLNVLLDFSIQHVYHEITVLAELMQRKTNDQGEQERKMSLVHFAHATRSQFLKLVALVKWIRVSKRMDVCYSIDYLLDLQSQYFIDTADRLVAMTRGDLELARLPEYHIAPAIDVLVLGTYNRMPSKIKEAFIPPAKITPREQKQVCARLNQLIETRLSRLSSGIPPNYKEIHVANGIATLLVPGEFEIKITLLGETEMTKWSLLNIKILVEDYELGMGLPLVHNLQLNQIHGVLQSRMDVAVNPVKEAFFNLHSFCVSLQLDVLYCQTSRMAAGRLRENIVIEKYDPKERMLVVGYWVKRSKNKRLTVGQVKIDAQYRVQIYEDKDDKLGGLKVRHFPHAPRLGTIDCASGMLSMDRMLSETFAVRCSERLMRLRRILEAAEPLLEVRMTGSNVPTLSLSLLPDTSSNEEMLTVSVNSFCGKVICNINVLNSENDDLVAFAKALYSSRCSGQTIRDYLQKLRTSLVIERYRRSVAALPVREIKETELLPFVKVMLREAPKQRIILQYTRSENYYLIVGFIPEGEDVVTTKLQLLECDDERAQFIPLDNDTEVFQTAVADAVEQGTMRFKNCDDRISLLEECSREQRLAFAIITVEDRITYMYLATELQKKGVGVELRRDDAHVPGGLALHITNVKTVVPFDAAEFFKCCVRSCLRLDNRTRHTFQFEMCFENIPLVRDVPHGLAHRREGDKDTTWVQEISQVNQMTPEKLVEGIIHRLMRYLYMYKVVHQFSLAYEQYFKQWCNVEVYTFHKLVVSYGENRDMLMVLAFNVKSQNPGSQEDYFLMNFGQTMPHSQFNTPEVDWLKKPRYNPHAMMSQLLRDELKKNNDLIYIMHYLCETIRPFMVIGKFGRIRFQSQKSLSQLIGPEVFFPYRLKYHLAVLDLTTLRLMRGNVILEIKMLEGQKVAVRDVSRYRARCAGLYQLFSNIDPVTTEIMCEELEIPESDNKINAGPTMWKPEQFMDAVDVPHEDDPRMKITSLPILMTHDTIIKACDFQEIDGHVTCPLDEYLYSISYLQRALLTLERMSPRAQQGPANNLFSGYVTVVDAKPDYVRFKATQLNGDGTNATAMVYYKIYLCPEAMTLKIHIEYDEGTNSEATPKNLTALSTYFEKVVFRCGDEYALQSYVVMTRVTSFGATASIANLMNAQMDISLESKCCLQLSLTYNNTTSKKLAPATKVDQQLNNMIINVIISQSRKADSFSVLRFIYRIKEWVICYSCLKKSEVNFVTVPSELNKQLIDDVNTEVKTTGKCAIWALVSLVSDRFRSGEWNPSNQDEPIISTVAPPAPQQYVNPPSVAPGSIAPPGSGAPQQQQHQQQPPPSVMQPGSMMGPQSVNAHQYGMHRQMGGPPSMQMNPSSVGPPPGSVGMPGSVGPGSMMNPGSHQQHMMNPGSVGPGSVGGPGSVNPGSVGYPPWGPGGQQYHHHMQYPPQ
Length1540
PositionTail
OrganismCaenorhabditis briggsae
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Rhabditina> Rhabditomorpha> Rhabditoidea> Rhabditidae> Peloderinae> Caenorhabditis.
Aromaticity0.08
Grand average of hydropathy-0.266
Instability index43.63
Isoelectric point6.40
Molecular weight173904.05
Publications
PubMed=14624247

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). 
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31395
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     173.46|      24|      24|    1462|    1485|       1
---------------------------------------------------------------------------
 1409- 1430 (40.92/22.13)	PGSIAPPGSG.AP.Q.QQQHQQQ..PP
 1431- 1448 (34.38/17.24)	P.SV.....M.QP.G.SMMGPQSVNAH
 1449- 1472 (30.90/14.64)	..QYGMHRQMgGPpS.MQMNPSSVGPP
 1473- 1490 (35.37/17.98)	PGSVGMPGSV.GP.G.SMMNP......
 1519- 1539 (31.89/15.37)	...VGYP.PW.GP.GgQQYHHHMQYPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     124.97|      35|     107|     631|     665|       4
---------------------------------------------------------------------------
  590-  614 (28.12/17.10)	..........VRE.IKETELLPFVKVMLREAPKQRI
  617-  652 (52.12/39.03)	QYTRSENYYLIVGfIPEGEDVVTTKLQLLECDDERA
  653-  684 (44.74/32.28)	QFIPLDNDTEVFQ.TAVADAVEQGTMRFKNCDD...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.72|      12|      59|     725|     739|       5
---------------------------------------------------------------------------
  725-  739 (17.72/16.24)	VELRRDdahVPGGLA
  784-  795 (23.99/12.29)	IPLVRD...VPHGLA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     114.21|      35|      59|    1098|    1154|       6
---------------------------------------------------------------------------
 1098- 1133 (56.72/70.41)	TIIKACDFQ..EIDGHVTCPLDEYLYSIsYLQRALLTL
 1158- 1194 (57.49/26.12)	AKPDYVRFKatQLNGDGTNATAMVYYKI.YLCPEAMTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.69|      10|     105|    1398|    1407|       8
---------------------------------------------------------------------------
 1398- 1407 (20.63/ 9.98)	PQQYVNPPSV
 1505- 1514 (19.06/ 8.64)	PGSVGGPGSV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.72|      20|     105|     430|     462|      15
---------------------------------------------------------------------------
  139-  158 (35.30/11.46)	NDQGEQERKMSLVHFAHATR
  434-  453 (36.43/26.76)	EDKDDKLGGLKVRHFPHAPR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.20|      12|      16|     875|     890|      19
---------------------------------------------------------------------------
  875-  890 (16.02/17.71)	LMVLAFNVksqnPGSQ
  895-  906 (24.18/13.83)	LMNFGQTM....PHSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.01|      21|      24|    1037|    1057|      20
---------------------------------------------------------------------------
 1037- 1057 (36.54/28.19)	NIDPVTT....EIMCEELEIPESDN
 1058- 1082 (31.48/23.02)	KINAGPTmwkpEQFMDAVDVPHEDD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31395 with Med14 domain of Kingdom Metazoa
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