<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31394

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGVIMDEPNVGGHPKGPSVPDSSRNGIPPLSGSDGAHGVSSAHNDGANRLNGSAKGIDGYKQNVDSSTTKIDFVGLRQPPELPHITQGFFPFSKLVNRSVQQCWNELSELITELAEVQVPPQDSGPLPGAPNGKPLGNQSEQNLQKKLRLLDFAHSKRAEFIKLLVLSQWSRQAADVSRLIDIQNFIRIRHQAYAGALQCIGDMKRDLVQAQVGNPDLKTALEVLAKGKVVSMPTLGYKPPRPLTAKGALKRLQKINRLISARLVLSDSVPTPFQTYRVHDGRVTFIVPDEFELDLSIGAEDETSQFYFVDIRFLFTPSSPIPKGRIFNELDMRINDTLRTKGLAGCFDLLHGLVLTTKINALFKQAAELARGLWSDTLRVELLHRTLVLQYWTLRPGPKSWLEIGIKSGRRSSENSINGLPSIGLRWIRDGQEVDSRDIEFDSKNLSMECILRSVIALHTSHILSSAFEKLSKHSLFSTGALSLRGRLSRTEPGACQLDVQLTRSRHLRVSVEPMSGTSILSTTPSTLERSDVDRNTDKPFADEIVSRVARLRCISAIEEVESNAKLLGFQVVNPRSLKLDFRRHFPANILRFSFFWHRSWERNWVLAATSSMDGDSWWVVQLQPAVPSESALPFDANSGISAPRSAQIVCNTFFPAPQHNMKSPFADMGHSLYGILTMQANARYLADLQSISFHPPLPQLVIEASLQVPDILIHYQALKLPRAFQVAMPAELARRSFIKDTIRLAFSGVDPHEKAAVLVAYGELLSPPNDVGALVSKQDRSLVLHHGGNKFAIRLLTAAGRSAMCELLESLQRLECALSILETLRRKKMQPQSLSLSRVGFLYGPRAELSANIDINLTTSSTHTIIDPLHLVTQEKPLFQLRLGIAFDYPNPHRRMQGSFTSLLNNAGATSSLGTVTGLLSVTLPLMQALDGLMANPSHKDPLRVQVIARNAKTFQIHYPMQKVRFQLLITQRPNSLVWVLREAGGLQGRSSEDQLKSRLKERLYHSKGDGWQGLENGVVATIDKVGNLLTELDKCFSGLDDIPILNQSPLETKPIPSKPTMGNTEPAASGNTVQNARLENKSPQKAAATHSNADVITID
Length1103
PositionTail
OrganismAspergillus terreus (strain NIH 2624 / FGSC A1156)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Circumdati.
Aromaticity0.06
Grand average of hydropathy-0.228
Instability index47.41
Isoelectric point9.32
Molecular weight121853.21
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors (By similarity). 


ECO:0000250	

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31394
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     138.82|      45|      75|     838|     885|       1
---------------------------------------------------------------------------
  838-  885 (67.39/49.33)	SLSRVGFLYGPRAELSANIDiNLTTSSTHTiiDPL..HLVTQEKPLFQLR
  915-  961 (71.43/42.37)	SLGTVTGLLSVTLPLMQALD.GLMANPSHK..DPLrvQVIARNAKTFQIH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.73|      14|      71|     577|     590|       2
---------------------------------------------------------------------------
  577-  590 (27.13/18.30)	PRSLKLDFRRHFPA
  646-  659 (27.60/18.76)	PRSAQIVCNTFFPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     152.84|      50|     551|     197|     262|       6
---------------------------------------------------------------------------
  101-  153 (82.85/41.47)	VQ.QCWN.ELSELITELAEVQVPpqdSGPLPGAPNGKPLGNQSE.QNLQKKLRLLD
  210-  262 (70.00/68.43)	VQaQVGNpDLKTALEVLAKGKVV...SMPTLGYKPPRPLTAKGAlKRLQKINRLIS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31394 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MPGVIMDEPNVGGHPKGPSVPDSSRNGIPPLSGSDGAHGVSSAHNDGANRLNGSAKGIDGYKQ
2) QSPLETKPIPSKPTMGNTEPAASGNTVQNARLENKSPQKAAATHSNAD
1
1051
63
1098










Molecular Recognition Features






MoRF SequenceStartStop




NANANA